Project description
Ubiquitin-related diagnostics and therapeutic agents in autoimmunity
Ubiquitination is a post-translational modification (PTM) critical in numerous biological processes (autoimmunity, cancer). Research has targeted the ubiquitin machinery to elucidate ubiquitin dependent events in pathologies. However, high-throughput methodologies for monitoring ubiquitination in clinical samples are lacking. Existing tools mainly deliver a qualitative sense of ubiquitin substrates and are limited by the need for unique expertise and large amounts of biological material. A PTM-profiling tool that utilises enzymatic activity in biological samples (as liquid biopsies), enabling read-outs of several PTMs, across thousands of proteins simultaneously, was established. The ERC-funded PTMActKit project will apply this platform technology to discover and develop ubiquitin-related diagnostics and therapeutic agents in the autoimmunity domain.
Objective
Ubiquitination is a post-translational modification (PTM) that is critical for numerous biological processes, including cell cycle, autoimmunity, immune responses, and cancer. This has instigated vast interest in targeting the ubiquitin machinery, and in elucidating ubiquitin-dependent events in pathologies. However, a key constraint is the lack of high-throughput methodologies for monitoring ubiquitination in clinical samples. Current tools mostly provide a qualitative sense of ubiquitin substrates and are limited by the need for unique expertise and large amounts of biological material. To address this gap, we have established a PTM-profiling tool that utilizes enzymatic activity in biological samples (e.g. liquid biopsies), enabling readouts of several PTMs, across thousands of proteins, for multiple samples simultaneously. We will employ our platform technology to the discovery and development of ubiquitin-related diagnostics and therapeutic agents in the field of autoimmunity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC1
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7610001 Rehovot
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.