Project description
Sugar-based cancer diagnostics
Glycosylation is the most common post-translational modification of proteins found on cell membranes. This leads to the formation of a sugar-based coating on cells known as glycocalyx that mediates cell adhesion and communication with other cells. Glycocalyx is dynamically regulated by physiological and pathophysiological stimuli such as cancer. The ERC-funded SweetCancerTest project will develop a novel diagnostic approach, based on the dysregulated protein glycosylation process of cancer. Researchers aim to design assays that can detect tumour-associated glycan structures to diagnose cancer at an early stage. The SweetCancerTest test will also assist to optimise treatment and monitor clinical outcome.
Objective
Cancer is a leading cause of death worldwide and novel diagnostic and therapeutic approaches are much needed. All living cells are covered with a dense layer of sugar-coat that is altered in cancer. One of the hallmarks of cancer is the expression of aberrant cell surface glycosylation patterns compared to normal cells. Current antibody-based assays against cancer glycans are commonly utilized to monitor clinical response to therapy, however none is useful for early detection or diagnosis due to low sensitivity and specificity. We aim to develop cancer diagnostics based on signatures of carbohydrate-neoantigens. We developed a unique system to generate potent antibodies of high specificity and affinity against various cancer glycans. Such potent antibodies that recognize tumor-associated carbohydrate-neoantigens can potentially be used as novel cancer diagnostics. Such validated tools could be used to identify cancer at an early stage and also for optimizing therapy to patients of unique sugar-code signatures.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC1
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.