Objective
With the NeutrAD ERC PoC project, we present the first disease-modifying Alzheimers Disease (AD) drugs that abrogate leukocyte-mediated neurotoxicity and represent a novel class of drugs in the treatment of AD.
AD is a neurological disorder characterized by progressive deterioration of cognitive function and leads to death within 3-9 years after diagnosis. AD is highly prevalent in elderly, and it is estimated that 35M patients suffer from the disease worldwide. As a result, AD has tremendous social and economic impact. This is aggravated by the lack of disease-modifying drugs, as current therapies only provide short-term symptomatic benefit. Hence, novel therapeutic approaches are of critical importance to resolve this urgent and growing health crisis.
Our novel anti-AD drug candidates use a neutrophil-targeted approach and unlock a novel avenue for the millions that suffer from AD. Growing evidence supports the role of inflammation in the development of neurodegeneration in AD. For example, our previous research has demonstrated a role for neutrophils in the induction of memory decline and neuropathological hallmarks of AD. Furthermore, our data shows that a highly activated and degranulating neutrophil phenotype induces neurotoxicity in an in vitro AD context. Preliminary results have also demonstrated that our novel drug candidates rescue neuronal death and have disease-modifying potential in AD-like mouse models.
In NeutrAD, we will explore the technical and commercial potential of our drug candidates as the first disease-modifying drugs against AD. Specifically, we will optimise and subsequently test the technical feasibility of our two drug candidates in AD-like in vitro and in vivo models. In parallel, we will explore the commercial opportunity of our novel AD drugs and analyse the IP position and strategy, as well as the market and (existing and emerging) competitors. Finally, we will consolidate the project outcomes in an investor-ready business plan.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC1
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
37129 Verona
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.