In the general context of organic synthesis and medicinal chemistry, we are working on four different research projects:
For example, we are particularly interested in the preparation and modification of heterocycles, a type of molecule consisting of rigid, cyclic structures that contain atoms other than carbon and hydrogen, especially nitrogen. Most of the commercial drugs used every day belong to this type of compound—heterocycles. For this reason, some of our efforts are directed towards their preparation, in some cases starting from the addition of two acyclic structures. In this project, the main reaction is the fusion of two of these molecules to form a new heterocyclic molecule, called pyrazole. We have already found experimental conditions to perform this reaction efficiently.
On the other hand, a second individual project aims at modifying these pyrazole structures by creating new bonds and attaching new functional groups to them. In particular, we have developed a new trifluoromethylation reaction for the design and development of reaction conditions to add a trifluoromethyl group to the pyrazoles. These new entities can be of great interest in the design of new pharmaceutical compounds.
In parallel, another project focuses on modifying certain amino acids, which are key organic molecules found in every protein and many drugs. This is a very hot topic in modern organic chemistry. We have successfully added new functional groups using a new and modern method, which can be seen as an interesting modification of previously known procedures.
Finally, the synthesis and preparation of highly functionalized alkenes is the objective of our last project. Alkenes are special organic motifs that are generally more reactive than alkanes, allowing for richer reactivity and access to more complex molecules. In this case, we have been able to attach reactive functional groups and atoms to the alkenes, such as boron atoms and nitrogen-containing motifs. In this way, very versatile and reactive species can be created. The reactions developed for this purpose are also of great novelty and interest.
In general, by modifying all these structures, we can create new versions of existing drugs with different properties, such as enhanced effectiveness, reduced side effects, or even new ways to treat diseases.
In parallel to the doctoral candidates' research activities, AiRPaDD training programme is equipping researchers with a strong interdisciplinary skill set, combining advanced scientific knowledge with transferable skills that will be essential for their future careers.
