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BIOS: The bio-intelligent DBTL cycle, a key enabler catalysing the industrial transformation towards sustainable biomanufacturing

Objective

The usage of fossil resources leading to increasing atmospheric CO2 levels and global climate change should be rapidly replaced by implementing a circular economy. Circular bioeconomy converting sustainable substrates in moderately operating bioprocesses offers a plenitude of solutions. While synthetic biology provides a multitude of tools for strain engineering, their rapid use in hosts for optimal performance under industrial conditions is still challenging. Promising innovations are often trapped in the ‘valley-of-death’ as strain engineering faces a too complex space of putative manipulations. Novel approaches are needed to increase speed and success rate of strain and bioprocess engineering.
The bio-intelligent approach, rigorously applied in BIOS, aims to accelerate and improve the conventional ‘design-build-test-learn’ (DBTL) cycle for strain and bioprocess engineering. Interdisciplinary collaboration will bridge microbiology, molecular biology, biochemical engineering with informatics, automation engineering, and mechanical engineering. Novel innovative metrics, biosensors, and bioactuators are developed for bi-directionally communication at biological-technical interfaces. Digital twins are created mimicking cellular and process levels. Integrating AI not only improves prediction quality but also enables hybrid learning, the key reason to increase speed and success rate in the novel bio-intelligent DBTL cycle (biDBTL). The power of biDBTL will be showcased by creating P. putida producer strains for terpenes, polyolefines, and methylacrylate. All are highly attractive products with a high potential for reducing anthropogenic greenhouse footprint. BIOS will open the door to a de-centralized, networked collaboration for strain and process engineering that efficiently links individual expertise for the sake of a symbiotic and rapid progress. BIOS also paves the way to de-centralized bio-manufacturing by implementing autonomous, self-controlled bioprocesses.

Coordinator

UNIVERSITY OF STUTTGART
Net EU contribution
€ 1 512 806,00
Address
Keplerstrasse 7
70174 Stuttgart
Germany

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,25

Participants (6)

LIFEGLIMMER GMBH
Germany
Net EU contribution
€ 795 680,00
Address
Markelstrasse 38
12163 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
WAGENINGEN UNIVERSITY
Netherlands
Net EU contribution
€ 1 302 100,00
Address
Droevendaalsesteeg 4
6708 PB Wageningen

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Region
Oost-Nederland Gelderland Veluwe
Activity type
Higher or Secondary Education Establishments
Other funding
€ 500,00
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
Net EU contribution
€ 581 038,00
Address
147 Rue De L'universite
75007 Paris Cedex 07

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 790 216,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,25
TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
Finland
Net EU contribution
€ 653 952,75
Address
Tekniikantie 21
02150 Espoo

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Research Organisations
Other funding
€ 0,00
TARTU ULIKOOL
Estonia
Net EU contribution
€ 649 375,00
Address
Ulikooli 18
51005 Tartu

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Partners (2)

INGENZA LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Roslin Innovation Centre, Charnock Bradley Buildin Easter Bush Campus, Bush Farm Road,
EH25 9RG Roslin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Eastern Scotland East Lothian and Midlothian
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
LUCITE INTERNATIONAL UK LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Cassel Works New Road
TS23 1LE Billingham

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Region
North East (England) Tees Valley and Durham Hartlepool and Stockton-on-Tees
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data