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CORDIS - EU research results
CORDIS

BIOS: The bio-intelligent DBTL cycle, a key enabler catalysing the industrial transformation towards sustainable biomanufacturing

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Rev. LCA (opens in new window)

Report- Overview of LCA basic information

CRISPR-NA (opens in new window)

Tool - Non-automated CRISPR protocol

CRISPR-MULTI (opens in new window)

Multiplex CRISPRi/a/transposon protocols

AutoSeq (opens in new window)

Report - SOPs fully automated transcript seq

Design Review (opens in new window)

Report - Critical design review

E-GEM (opens in new window)

Model is set

Safe-by-design (opens in new window)

Safe-by-design framework

FlexGene (opens in new window)

Tool - Flexible gene expression system set

Cellular metabolism (opens in new window)

Model is set

Prototype DoE (opens in new window)

Protoype of simplified embeddings for autonomous DoE

Process model (opens in new window)

Model is set

Open Science I (opens in new window)

Stakeholder meeting report I

Transmod (opens in new window)

Tool is set: The cellular model allows to predict in vivo elongation rates in P. putida for a marker protein based on the DNA/RNA sequence

ANN models (opens in new window)

Machine Learning Software

Transformation (opens in new window)

Report - Protocol for cell transformation

Stress tolerance (opens in new window)

Identification of factors inducing stress in P. putida producer strains - Analysis of various stress responses in P. putida engineered strains. As a result of serial stress tests with stressors such as terpenoids, methanol, formats, lignin, and methacrylates stress responses are identified and hints for key tuning parameters found.

C1 growth (opens in new window)

Other -PHA producers grows on C1 source

Biotransformation (opens in new window)

Other - Improved biotransformation from methanol & formate

ALE-optimized strains (opens in new window)

Other - Metabolic modules optimized by ALE

Lycopene 0 (opens in new window)

Other- P. putida lyc0 platform engineered

MD design (opens in new window)

Other - Model discriminating design experimentally evaluated

Public Call (opens in new window)

Public call for subcontraction launched

Dissemination plan (opens in new window)

Dissemination plan set

RL-VAE (opens in new window)

Other - Training methods for machine learning

Transformation platform (opens in new window)

Tool -Automated transformation platform

Microfluidic (opens in new window)

Tool- First microfluidic system including electrodes, pumps and electroporation generator – a microfluidic system is engineered that allows electroporation of microbes in an automated manner in preliminary tests.

Rapid prototyping (opens in new window)

Tool - rapid prototyping basics established

Publications

Microbial Biotechnology (opens in new window)

Author(s): Marco A. Campos‐Magaña; Vitor A. P. Martins dos Santos; Luis Garcia‐Morales
Published in: Microbial Biotechnology, 2025, ISSN 1751-7907
Publisher: Wiley
DOI: 10.1111/1751-7915.70104

Paving the way for synthetic C1 - Metabolism in Pseudomonas putida through the reductive glycine pathway (opens in new window)

Author(s): Lyon Bruinsma, Sebastian Wenk, Nico J. Claassens,, Vitor A. P. Martins dos Santos
Published in: Metabolic Engineering, 2023, ISSN 1096-7176
Publisher: Elsevier
DOI: 10.1016/j.ymben.2023.02.004

Valorising waste in biomanufacturing: Complexities of circularity, safety and sustainability (opens in new window)

Author(s): Alexandra Müller, Zoë Robaey, Fathya Hekmatyar, Nikhil Bharadwaj Sairam, Christos Batianis, Enrique Asin-Garcia, Vitor A.P. Martins dos Santos
Published in: Journal of Cleaner Production, Issue 528, 2025, ISSN 0959-6526
Publisher: Elsevier BV
DOI: 10.1016/J.JCLEPRO.2025.146685

Trends in Biotechnology (opens in new window)

Author(s): Asin-Garcia, Enrique; Fawcett, James D.; Batianis, Christos; Martins dos Santos, Vitor A.P.
Published in: Trends in Biotechnology, 2025, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/J.TIBTECH.2024.10.014

Metabolic Engineering (opens in new window)

Author(s): Batianis, Christos; van Rosmalen, Rik P.; Major, Monika; van Ee, Cheyenne; Kasiotakis, Alexandros; Weusthuis, Ruud A.; Martins dos Santos, Vitor A.P.
Published in: Metabolic Engineering, 2023, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/J.YMBEN.2022.10.002

Multilayered safety framework for living diagnostics in the colon (opens in new window)

Author(s): Sonia Mecacci; Lucía Torregrosa-Barragán; Enrique Asin-Garcia; Enrique Asin-Garcia; Robert W. Smith
Published in: Frontiers in Systems Biology, 2023, ISSN 2674-0702
Publisher: Frontiers Media SA
DOI: 10.3389/FSYSB.2023.1240040

Metabolic Engineering (opens in new window)

Author(s): Batianis, Christos; van Rosmalen, Rik P.; Major, Monika; van Ee, Cheyenne; Kasiotakis, Alexandros; Weusthuis, Ruud A.; Martins dos Santos, Vitor A.P.
Published in: Metabolic Engineering, 2023, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2022.10.002

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