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A Modular Framework for Designing and Producing Biohybrid Machines

Objective

Bio-hybrid machines (BHMs) combine living cell actuators with artificial materials in order to achieve greater autonomy, flexibility, and energy efficiency compared to standard robots. However, BHMs are developed in silos of individual research groups, making their development more of an art relying on individual knowledge, intuition, and skills than on standardized decision-making processes.
To push the manufacturing of BHMs towards bio-intelligent paradigm and model-based engineering, we propose to develop a self-monitoring and self-controlling manufacturing pipeline of BHMs. To realize such a pipeline, we would need to (i) Develop a modeling and simulation framework that will streamline the processes of design, quoting, manufacturing, verification, and reporting, thus significantly reducing error-prone manual steps. Also, given that actuators in BHMs are living cells, which greatly expands the parameter space, we believe that the development of BHMs would greatly benefit from AI-guided modeling process to optimize search for the most efficient design; (ii) To experimentally test, optimize, and verify the platform by developing a proof-of-principle reconfigurable modular catheter BHM; (iii) To group all necessary manufacturing equipment into an integrated bio-intelligent manufacturing cell (BIMC) and demonstrate its adaptable operation.
As a proof-of-principle, we will use BHM catheter as it is an innovative medical device that would be able to arrive into hard-to-reach regions of the human body and release drugs there.

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-RIA - HORIZON Research and Innovation Actions

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Call for proposal

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(opens in new window) HORIZON-CL4-2021-DIGITAL-EMERGING-01

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Coordinator

UNIVERZITET U NOVOM SADU, POLJOPRIVREDNI FAKULTET NOVI SAD
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 420 572,50
Address
TRG DOSITEJA OBRADOVICA 8
21000 Novi Sad
Serbia

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Region
Србија - север Регион Војводине Јужнобачка област
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 420 572,50

Participants (5)

Partners (1)

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