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A Modular Framework for Designing and Producing Biohybrid Machines

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Plan for Dissemination, Exploitation and Communication (opens in new window)

Plan will be periodically updated and presented at periodic review meetings.

Performance simulations and analysis of results (opens in new window)

Report on performed simulations, their correlation with experiments and analysis of predictive power. Updated at month 36.

Data management plan (opens in new window)

Data management plan done in accordance to EC template

The Framework specifications (opens in new window)

Periodic reports on the initial framework specifications (M06) and further developments, standards implemented, how it is integrated with the BIMC development. Deliverable updates will be done at Months 18 and 36

Experimental performance (opens in new window)

Report on performed tests and obtained results. Updated at month 36

Catheter muscle integration (opens in new window)

Report on integrating muscle contraction-based motion into a catheter, the production methods chosen and parameters used for that choice.

Report of the kick-off meeting (opens in new window)

Report of the decisions from the kick-off meeting.

Additional simulation modules (opens in new window)

Report on developed modules for simulating electric stimulus-response and rotation&bending dynamics, how they are implemented, and performance results.

Early career development (opens in new window)

Periodic reports on performed activities described in T5.2. Updated at Month 36.

IP, regulation and dissemination report (opens in new window)

Periodic reports on performed activities in T5.5-6. Updated at month 36.

System observables (opens in new window)

Report on the estimated main observable parameters for modelling biohybrid catheter.

Culture and actuator chamber with integrated sensors (opens in new window)

Progress report (M18) and the final report (M28) on the chamber design and fabrication.

Test plan & cases (opens in new window)

Report on developed documentation templates, test plan, test cases and updates (on months 18 and 30).

Uncertainty analysis (opens in new window)

Reports on uncertainty & sensitivity analyses, and acceptability ranges. Updated at month 36.

3D evolvable simulator (opens in new window)

Report on the implemented voxel-based simulator, how it is integrated with evolvable algorithms and performance results.

Machine learning optimization (opens in new window)

Report on DNN methodology applied, tests performed, parameter and metaparameter optimizations, performances. The updated version will be uploaded in month 36.

Feedback system control software (opens in new window)

Progress report (M18) and the final report (M32) on the control software development, testing and calibration results.

Bill of materials (opens in new window)

Report on the first version (M06) and the final, updated BOM will be updated at M24

BHM Catheter skeleton design and fabrication (opens in new window)

Report on catheter design, structure, materials used, test results.

Publications

Bio-intelligent manufacturing cell for bio-hybrid machines fabrication (opens in new window)

Author(s): Teti, Roberto; Caggiano, Alessandra; Balaz, Igor
Published in: Procedia CIRP, 2024, ISSN 2212-8271
Publisher: Elsevier
DOI: 10.1016/J.PROCIR.2024.08.275

Mechanical Deformation Effects on Flexible Thin Film Transistors: A Comparison Between 6,13‐Bis(Triisopropylsilylethynyl)Pentacene and N,N′‐Bis‐(2‐Ethylhexyl)‐1,7‐Dicyanoperylene‐3,4:9,10‐bis(Dicarboximide) Derivatives (opens in new window)

Author(s): A. Mascia, M. Concas, E. Podda, G. Casula, S. Lai, P. Cosseddu
Published in: Advanced Materials Interfaces, Issue 12, 2025, ISSN 2196-7350
Publisher: Wiley
DOI: 10.1002/ADMI.202400783

Outline of an evolutionary morphology generator towards the modular design of a biohybrid catheter (opens in new window)

Author(s): Michail-Antisthenis Tsompanas; Michail-Antisthenis Tsompanas; Igor Balaz
Published in: Frontiers in Robotics and AI, 2024, ISSN 2296-9144
Publisher: Frontiers Media SA
DOI: 10.3389/FROBT.2024.1337722

Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications (opens in new window)

Author(s): David Esporrín‐Ubieto, Juan C. Fraire, Daniel Sánchez‐deAlcázar, Samuel Sánchez
Published in: Advanced Materials, Issue 37, 2025, ISSN 0935-9648
Publisher: Wiley
DOI: 10.1002/ADMA.202502171

Bio-Hybrid Steerable Catheter Fabrication and Assembly within the EC ‘BioMeld’ Project - Part 1: Manufacturing Process Steps (opens in new window)

Author(s): Roberto Teti, Alessandra Caggiano
Published in: Procedia CIRP, Issue 138, 2026, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/J.PROCIR.2026.01.204

Development of an electrical current stimulator for controlling biohybrid machines (opens in new window)

Author(s): Riccardo Collu, Judith Fuentes, Florencia Lezcano, Maria Crespo-Cuadraro, Andrea Bartolucci, Leonardo Ricotti, Lorenzo Vannozzi, Samuel Sánchez, Stefano Lai, Massimo Barbaro
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-06465-0

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity (opens in new window)

Author(s): Stefano Lai; Judith Fuentes; Maria Guix; Giulia Casula; Piero Cosseddu; Samuel Sánchez
Published in: Advanced Intelligent Systems, 2024, ISSN 2640-4567
Publisher: Wiley Online Library
DOI: 10.1002/AISY.202400407

Ferrofluid‐Based Bioink for 3D Printed Skeletal Muscle Tissues with Enhanced Force and Magnetic Response (opens in new window)

Author(s): Judith Fuentes; Maria Guix; Zoran M. Cenev; Anna C. Bakenecker; Noelia Ruiz‐González; Grégory Beaune; Jaakko V.I. Timonen; Samuel Sanchez; Veronika Magdanz
Published in: Advanced Materials Interfaces, 2025, ISSN 2196-7350
Publisher: Willey
DOI: 10.1002/ADMI.202400824

Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy (opens in new window)

Author(s): Brenda G. Molina, Judith Fuentes, Carlos Alemán, Samuel Sánchez
Published in: Biosensors and Bioelectronics, Issue Volume 251, 1 May 2024, 116117, 2024, ISSN 0956-5663
Publisher: Elsevier
DOI: 10.1016/j.bios.2024.116117

Bioengineering fascicle-like skeletal muscle bioactuators via pluronic-assisted co-axial 3D bioprinting (PACA-3D) (opens in new window)

Author(s): Judith Fuentes, Rafael Mestre, Maria Guix, David Esporrín-Ubieto, Ibtissam Ghailan Tribak, Noelia Ruiz-González, Tania Patiño, Samuel Sánchez
Published in: Biofabrication, Issue 17, 2025, ISSN 1758-5082
Publisher: IOP Publishing
DOI: 10.1088/1758-5090/ADDC9B

Outline of an evolutionary morphology generator towards the modular design of a biohybrid catheter (opens in new window)

Author(s): Michail-Antisthenis Tsompanas, Igor Balaz
Published in: Frontiers in Robotics and AI, 2024, ISSN 2296-9144
Publisher: Frontiers Media SA
DOI: 10.3389/frobt.2024.1337722

Multicellular muscle-tendon bioprinting of mechanically optimized musculoskeletal bioactuators with enhanced force transmission (opens in new window)

Author(s): Miriam Filippi; Diana Mock; Judith Fuentes; Mike Y. Michelis; Aiste Balciunaite; Pablo Paniagua; Raoul Hopf; Adina Barteld; Selina Eng; Asia Badolato; Jess Snedeker; Maria Guix; Samuel Sanchez; Robert K. Katzschmann
Published in: Science Advances, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.3929/ETHZ-B-000745894

Fabrication of Flexible Double‐Gate Organic Thin Film Transistor For Tactile Applications (opens in new window)

Author(s): Mattia Concas; Antonello Mascia; Stefano Lai; Annalisa Bonfiglio; Piero Cosseddu
Published in: Advanced Materials Technologies, 2024, ISSN 2365-709X
Publisher: Wiley
DOI: 10.1002/ADMT.202400534

Soft robotics: what’s next in bioinspired design and applications of soft robots? (opens in new window)

Author(s): Cecilia Laschi; Li Wen; Fumiya Iida; Arsen Abdulali; Helmut Hauser; Yifan Wang; Ke Liu; Leonardo Ricotti; Matteo Cianchetti; Kaspar Althoefer; Pham Huy Nguyen; Mirko Kovač; Marcello Calisti
Published in: Bioinspiration & Biomimetics, 2025, ISSN 1748-3190
Publisher: IOP Publishing Ltd
DOI: 10.1088/1748-3190/AE066D

Wearable Stimulator for Upper and Lower Limb Somatotopic Sensory Feedback Restoration (opens in new window)

Author(s): Roberto Paolini, Riccardo Collu, Laura Tullio, Andrea Demofonti, Alessia Scarpelli, Francesca Cordella, Massimo Barbaro, Loredana Zollo
Published in: IEEE Transactions on Biomedical Circuits and Systems, Issue 20, 2026, ISSN 1932-4545
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TBCAS.2025.3607203

Optimizing the Substrate for Hypercube‐Based Neuroevolution of Augmented Topologies to Design Soft Actuators (opens in new window)

Author(s): Hugo Alcaraz‐Herrera, Michail‐Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Published in: Concurrency and Computation: Practice and Experience, Issue 37, 2026, ISSN 1532-0626
Publisher: Wiley
DOI: 10.1002/CPE.70204

Monolithic Biohybrid Flexure Mechanism Actuated by Bioengineered Skeletal Muscle Tissue (opens in new window)

Author(s): Andrea Bartolucci; Judith Fuentes; Daniele Guarnera; Florencia Lezcano; Maria Crespo‐Cuadrado; Lorena Guachi‐Guachi; Francesco Iacoponi; Carlotta Salvatori; Riccardo Collu; Massimo Barbaro; Stefano Lai; Leonardo Ricotti; Samuel Sánchez; Lorenzo Vannozzi
Published in: Advanced Intelligent Systems, 2025, ISSN 2640-4567
Publisher: Wiley Online Library
DOI: 10.1002/AISY.202400989

Biologicalisation in manufacturing – Current state and future trends (opens in new window)

Author(s): Konrad Wegener, Oliver Damm, Simon Harst, Steffen Ihlenfeldt, Laszlo Monostori, Roberto Teti, Rafi Wertheim, Gerry Byrne
Published in: CIRP Annals, Issue 72, 2025, ISSN 0007-8506
Publisher: Elsevier BV
DOI: 10.1016/J.CIRP.2023.05.005

Using neuroevolution for designing soft medical devices (opens in new window)

Author(s): Hugo Alcaraz-Herrera; Michail-Antisthenis Tsompanas; Igor Balaz; Andrew Adamatzky
Published in: Biomimetic Intelligence and Robotics, 2025, ISSN 2667-3797
Publisher: Elsevier
DOI: 10.48550/ARXIV.2408.09107

Bio-Hybrid Steerable Catheter Fabrication and Assembly within the EC ‘BioMeld’ Project - Part 2: Production Plan Achievement (opens in new window)

Author(s): Alessandra Caggiano, Roberto Teti
Published in: Procedia CIRP, Issue 138, 2026, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/J.PROCIR.2026.01.205

A novel concept of steerable catheters actuated by muscle cells: the BioMeld project

Author(s): Salvatori C, Ricotti L, Vannozzi L
Published in: 2023, ISSN 2724-2129
Publisher: Gruppo Nazionale di Bioingegneria

NeuroEvolution algorithms applied in the designing process of biohybrid actuators

Author(s): Alcaraz-Herrera, H., Tsompanas, MA., Balaz, I., Adamatzky, A.
Published in: Intelligent Distributed Computing XVII (IDC 2024), ISSN 1860-9503
Publisher: Springer

Incremental Growth on Compositional Pattern Producing Networks Based Optimization of Biohybrid Actuators (opens in new window)

Author(s): Tsompanas, MA
Published in: 2024, ISSN 1611-3349
Publisher: Springer Nature Switzerland AG
DOI: 10.1007/978-3-031-56855-8_17

A Modular Portable Current Stimulator for Electrical Stimulation of Excitable Tissues (opens in new window)

Author(s): Riccardo Collu, Stefano Lai, Antonello Mascia, Roberto Paolini, Elena Ferrazzano, Loredana Zollo, Piero Cosseddu, Massimo Barbaro
Published in: Lecture Notes in Electrical Engineering, Proceedings of SIE 2024, 2025
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-71518-1_54

Incremental Growth on Compositional Pattern Producing Networks Based Optimization of Biohybrid Actuators (opens in new window)

Author(s): Michail-Antisthenis I. Tsompanas
Published in: Lecture Notes in Computer Science - Applications of Evolutionary Computation, 2024
Publisher: Springer
DOI: 10.1007/978-3-031-56855-8_17

Control of Biohybrid Actuators Using Neuroevolution (opens in new window)

Author(s): Hugo Alcaraz-Herrera; Michail-Antisthenis I. Tsompanas; Igor Balaz; Andrew Adamatzky
Published in: Proceedings of the 16th International Joint Conference on Computational Intelligence, 2024, ISSN 2184-3236
Publisher: ScitePress Digital Library
DOI: 10.48550/ARXIV.2411.08261

A Novel Steerable Catheter Controlled with a Biohybrid Actuator: A Feasibility Study (opens in new window)

Author(s): Salvatori, C., Trucco, D., Niosi, I., Ricotti, L., Vannozzi, L.
Published in: 2023, ISSN 1611-3349
Publisher: Springer, Cham
DOI: 10.1007/978-3-031-39504-8_26

Development of an electrical current stimulator for controlling biohybrid machines (opens in new window)

Author(s): Collu, Riccardo; Fuentes, Judith; Lezcano, Florencia; Crespo-Cuadraro, Maria; Bartolucci, Andrea; Ricotti, Leonardo; Vannozzi, Lorenzo; Sánchez, Samuel; Lai, Stefano; Barbaro, Massimo
Published in: Scientific Reports, 2025
Publisher: IEEE
DOI: 10.1038/S41598-025-06465-0

A Novel Steerable Catheter Controlled with a Biohybrid Actuator: A Feasibility Study (opens in new window)

Author(s): Carlotta Salvatori; Diego Trucco; Ignazio Niosi; Leonardo Ricotti; Lorenzo Vannozzi
Published in: Lecture Notes in Computer Science - Biomimetic and Biohybrid Systems, 2023
Publisher: Springer Nature
DOI: 10.1007/978-3-031-39504-8_26

Designing morphologies of soft medical devices using cooperative neuro coevolution (opens in new window)

Author(s): Hugo Alcaraz-Herrera, Michail-Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Published in: Proceedings of the Genetic and Evolutionary Computation Conference Companion, 2025
Publisher: ACM
DOI: 10.1145/3712255.3726671

NEAT and HyperNEAT based Design for Soft Actuator Controllers

Author(s): Alcaraz-Herrera, H., Tsompanas, M. A., Balaz, I., & Adamatzky, A.
Published in: Studies in Computational Intelligence
Publisher: Springer

A novel concept of steerable catheters actuated by muscle cells: the BioMeld project

Author(s): Salvatori, C., Ricotti, L., & Vannozzi, L.
Published in: NATIONAL CONGRESS OF BIOENGINEERING. PROCEEDINGS.. Patron Editore Srl.
Publisher: GNB Proceedings

NeuroEvolution Algorithms Applied in the Designing Process of Biohybrid Actuators (opens in new window)

Author(s): Hugo Alcaraz-Herrera; Michail-Antisthenis Tsompanas; Igor Balaz; Andrew Adamatzky
Published in: Studies in Computational Intelligence ISBN: 9783031876387, 2025
Publisher: Springer
DOI: 10.48550/ARXIV.2408.07671

Evaluating Fitness Averaging Strategies in Cooperative NeuroCoEvolution for Automated Soft Actuator Design (opens in new window)

Author(s): Hugo Alcaraz-Herrera, Michail-Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Published in: Communications in Computer and Information Science, Computational Intelligence, 2026
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-032-15635-8_8

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