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Minimally Invasive Neuromodulation Implant and implantation procedure based on ground-breaking GRAPHene technology for treating brain disorders

Objective

Neurostimulation therapies hold the promise to treat brain diseases refractory to pharmacological treatment. However, these therapies are not fully adopted due to important technological and clinical challenges, such as highly invasive implantation, multiple side effects due to off-target stimulation, low signal resolution and lack of personalized therapies. The MINIGRAPH project aims to develop a ground-breaking neuromodulation therapy that addresses current needs of the field. We will develop and validate a new generation of brain implants with closed-loop neuromodulation capabilities, enabled by skull implanted flexible electronics unit and miniature and high-density arrays of graphene microelectrodes. Our implant will feature high miniaturization, large spatial resolution and optimal biocompatibility with brain tissue. The closed-loop capabilities will enable to develop personalized and adaptive therapies depending on patients’ needs. In addition, we will also develop and validate a minimally invasive implantation procedure with high precision implantation and low invasiveness through a single small skull incision.

The MINIGRAPH project outcomes will truly revolutionize the way we treat neurological and neuropsychiatric diseases in the near future. To achieve our ambitious objectives, we have put together an interdisciplinary consortium formed by high-renowned research centers and a high-promising SME, with all the expertise and resources needed to complete the project within time and budget. Our project addresses the objectives of the “Tools to measure and stimulate activity in brain tissue” pathfinder challenge, as it provides 1) miniature and minimally invasive brain implants, 2) closed-loop neuromodulation therapy for personalized medicine, 3) biocompatible ultra-thin and flexible neuroelectrodes, and 4) minimized power consumption solution. All together, we believe the MINIGRAPH project will be a unique addition to the challenge portfolio.

Coordinator

FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Net EU contribution
€ 749 897,50
Address
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (4)

INBRAIN NEUROELECTRONICS SL
Spain
Net EU contribution
€ 1 095 500,00
Address
Calle Baldiri Reixac Sn 4-8 Ed2 Planta 3 Pta D8 Parc Cientific Barcelona Ed Cluster Ii
08028 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Belgium
Net EU contribution
€ 999 445,00
Address
Kapeldreef 75
3001 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 633 307,50
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 450 252,50
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00