Project description DEENESFRITPL Innovative neuromodulatory implants for the treatment of brain disorders Neurostimulation may decrease neurological and neuropsychiatric diseases refractory to pharmacological treatment. However, these procedures are associated with highly invasive implantation, imprecision, and multiple side effects. The EU-funded MINIGRAPH project aims to develop and validate innovative brain implants with closed-loop neuromodulation capabilities, controlled by implanted electronics units and miniature arrays of graphene microelectrodes. The project will introduce a minimally invasive, high-precision implantation procedure using a single small skull incision. The miniature implants will have optimal biocompatibility with brain tissue and provide large spatial resolution, enabling personalised and adaptive therapies for patients. Show the project objective Hide the project objective Objective Neurostimulation therapies hold the promise to treat brain diseases refractory to pharmacological treatment. However, these therapies are not fully adopted due to important technological and clinical challenges, such as highly invasive implantation, multiple side effects due to off-target stimulation, low signal resolution and lack of personalized therapies. The MINIGRAPH project aims to develop a ground-breaking neuromodulation therapy that addresses current needs of the field. We will develop and validate a new generation of brain implants with closed-loop neuromodulation capabilities, enabled by skull implanted flexible electronics unit and miniature and high-density arrays of graphene microelectrodes. Our implant will feature high miniaturization, large spatial resolution and optimal biocompatibility with brain tissue. The closed-loop capabilities will enable to develop personalized and adaptive therapies depending on patients’ needs. In addition, we will also develop and validate a minimally invasive implantation procedure with high precision implantation and low invasiveness through a single small skull incision. The MINIGRAPH project outcomes will truly revolutionize the way we treat neurological and neuropsychiatric diseases in the near future. To achieve our ambitious objectives, we have put together an interdisciplinary consortium formed by high-renowned research centers and a high-promising SME, with all the expertise and resources needed to complete the project within time and budget. Our project addresses the objectives of the “Tools to measure and stimulate activity in brain tissue” pathfinder challenge, as it provides 1) miniature and minimally invasive brain implants, 2) closed-loop neuromodulation therapy for personalized medicine, 3) biocompatible ultra-thin and flexible neuroelectrodes, and 4) minimized power consumption solution. All together, we believe the MINIGRAPH project will be a unique addition to the challenge portfolio. Fields of science engineering and technologynanotechnologynano-materialstwo-dimensional nanostructuresgraphenemedical and health scienceshealth sciencespersonalized medicinemedical and health sciencesmedical biotechnologyimplants Programme(s) HORIZON.3.1 - The European Innovation Council (EIC) Main Programme Topic(s) HORIZON-EIC-2021-PATHFINDERCHALLENGES-01-02 - Tools to measure and stimulate activity in Brain Tissue Call for proposal HORIZON-EIC-2021-PATHFINDERCHALLENGES-01 See other projects for this call Funding Scheme HORIZON-AG - HORIZON Action Grant Budget-Based Coordinator FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Net EU contribution € 749 897,50 Address Campus de la uab edifici q icn2 08193 Cerdanyola del valles Spain See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all INBRAIN NEUROELECTRONICS SL Spain Net EU contribution € 1 095 500,00 Address Calle baldiri reixac sn 4-8 ed2 planta 3 pta d8 parc cientific barcelona ed cluster ii 08028 Barcelona See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM Belgium Net EU contribution € 999 445,00 Address Kapeldreef 75 3001 Heverlee See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany Net EU contribution € 633 307,50 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ACADEMISCH ZIEKENHUIS LEIDEN Netherlands Net EU contribution € 450 252,50 Address Albinusdreef 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland Net EU contribution € 0,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Nanoflex Robotics A.G Switzerland Net EU contribution € 0,00 Address Weinbergstrasse 35, weh 8092 Zurich See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
