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PRInted Symbiotic Materials as a dynamic platform for Living Tissues production

Project description

Living tissue manufacturing using symbiotic materials

The EU-funded PRISM-LT project will use a hybrid living materials concept to create a flexible platform for living tissue manufacturing. The innovative bio-ink will contain stem cells integrated into a supporting matrix with engineered helper bacteria or yeast cells. The bioprinting process will produce a 3D patterned structure where stem cells could be induced to differentiate into different lineages. The directed stimulation of differentiating stem cells will force them to produce lineage-specific metabolites for sensing by the designer helper cells. The helper cells within the platform will then enhance localised lineage commitment to sustain differentiation stability. The project aims to implement this strategy for the development of two symbiotic materials designed for biomedical and food applications, respectively.

Objective

The PRISM-LT aims at creating a flexible platform for next generation living tissue manufacturing based on Hybrid Living Materials.

We plan to design a novel bio-ink where stem cells are integrated in a support matrix enriched with engineered helper cells (either bacteria or yeasts, depending on the application and requirements). Tuning the operational parameters of the bioprinting process, we will cast down the material controlling the mechanical properties of each voxel, to get to a 3D patterned structure where stem cells are locally induced to initiate their differentiation towards different lineages. As far as stem cells proliferate, the helpers remain in a quiescent state. However, when the stem cells get stimulated by the local (printed) mechanics and enter a differentiation pathway, they start secreting a pool of lineage-specific metabolites. The helper cells are designed to sense these early markers of differentiation, and to respond by producing in-situ the corresponding growth factors, providing the relevant chemical guidance. Helper cells within the platform amplify the initial lineage commitment in each area and dynamically sustain differentiation on a longer term.

During the project we will implement this strategy and develop two independent symbiotic materials, targeting biomedical and food applications, respectively.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-EIC - HORIZON EIC Grants

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-EIC-2021-PATHFINDERCHALLENGES-01

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Coordinator

IN SRL IMPRESA SOCIALE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 479 061,32
Address
VIA CARDUCCI 9A
33100 Udine
Italy

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Friuli-Venezia Giulia Udine
Activity type
Other
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 479 061,32

Participants (4)

Partners (1)

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