Transforming brain surgery by advancing functional-guided neuronavigational imaging

Información del proyecto

HyperProbe

Identificador del acuerdo de subvención: 101071040

DOI

10.3030/101071040

Fecha de la firma de la CE 8 Julio 2022

Fecha de inicio 1 Octubre 2022

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 3 548 325,00

Aportación de la UE

€ 3 360 825,00

Coordinado por

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data sets, microdata, etc (5)

Simple liquid phantom delivery

Delivery of the recipe of a liquid phantom to test the accuracy of HyperProbe1 in the quantification of clinical and optical biomarkers (UCL, DATA, PU, M24).A full dataset of results and a report will also be produced to describe and explain the outcomes.

Digital phantom delivery

Delivery of digital phantom for optimising the final parameters of HyperProbe1 UCL DATA PU M12A full dataset of results and a report will also be produced to describe and explain the outcomes

Prototype features definition

Definition of the essential features of the system for the prototype device (EMO, R, PU, M27)A full dataset of results and a report will also be produced to describe and explain the outcomes.

Lab system testing (HyperProbe1)

Preliminary testing and characterisation of laboratory system, HyperProbe1 (UNIFI, DATA, PU, M24)A full dataset of results and a report will also be produced to describe and explain the outcomes.

Image processing pipelines for registration of pre- and intraoperative imaging

Automatic image-processing pipelines for registration of intraoperative and preoperative optical imaging modalities (UCBL, DATA, PU, M24).A full dataset of results and a report will also be produced to describe and explain the outcomes.

Other (1)

Software tools for deep learning-based reconstruction

Delivery of software tools for deep learning-based reconstruction of optical images and quantitative parameter maps (TUM, OTHER, PU, M24).A piece of software, a full dataset of results and a report will also be produced to describe and explain the outcomes.

Demonstrators, pilots, prototypes (1)

Lab system development (HyperProbe1)

Development of a fullyworking laboratory version of the HyperProbe system UNIFI DEM PU M12A fully working setup and a report will also be produced to describe and explain the outcomes

Documents, reports (1)

Project website and visual identity

Project website and visual identity EIBIR R PU M3

Publicaciones

Conference proceedings (9)

Optical characterisation and study of ex vivo glioma tissue for hyperspectral imaging during neurosurgery

Autores: Luca Giannoni, Camilla Bonaudo, Marta Marradi, Alessandro Della Puppa, Francesco S. Pavone
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Edición 1262829, 2023, ISSN 0277-786X
Editor: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2670854

HyperProbe consortium: transforming neuronavigation in glioma surgery with hyperspectral imaging

Autores: Luca Giannoni, Anam Toaha, Marta Marradi, Duccio Rossi Degl’Innocenti, Ivan Ezhov, Charly Caredda, Arthur Gautheron, Fernand Fort, Fabien Schneider, Moncef Berhouma, Camilla Bonaudo, Frédéric Lange, Angelos Artemiou, Eszter Balázs, et al.
Publicado en: Optica Biophotonics Congress: Biomedical Optics 2024 (Translational, Microscopy, OCT, OTS, BRAIN), Edición TS5B.7, 2024, ISBN 978-1-957171-34-0
Editor: Optica Publishing Group
DOI: 10.1364/TRANSLATIONAL.2024.TS5B.7

Identifying chromophore fingerprints of brain tumor tissue on hyperspectral imaging using principal component analysis

Autores: Ivan Ezhov, Luca Giannoni, Suprosanna Shit, Frederic Lange, Florian Kofler, Bjoern Menze, Ilias Tachtsidis, Daniel Rueckert
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Edición 1262826, 2023, ISSN 0277-786X
Editor: SPIE
DOI: 10.48550/arXiv.2301.05233

Pixel-wise and real-time estimation of optical mean path length using deep learning: application for intraoperative functional brain mapping

Autores: Charly Caredda, Ivan Ezhov, Michaël Sdika, Frédéric Lange, Luca Giannoni, Ilias Tachtsidis, Bruno Montcel
Publicado en: Clinical Biophotonics III, 2024
Editor: SPIE
DOI: 10.1117/12.3016632

A digital instrument simulator to optimize the development of hyperspectral imaging system for neurosurgery.

Autores: Lange, F., Giannoni, L., Fort, F., Caredda, C., Montcel, B., & Tachtsidis, I.
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX;, Edición 126282C, 2023, ISSN 0277-786X
Editor: SPIE

A novel hyperspectral imaging tool for preclinical and translational investigations of brain tissue physiology and pathology

Autores: Luca Giannoni, Anam Toaha, Marta Marradi, Camilla Bonaudo, Alessandro Della Puppa, and Francesco S. Pavone
Publicado en: Optica Biophotonics Congress: Biomedical Optics 2024 (Translational, Microscopy, OCT, OTS, BRAIN), Edición JD6A.4, 2024, ISBN 978-1-957171-34-0
Editor: Optica Publishing Group

Evaluation of hyperspectral imaging measurements of changes in hemoglobin oxygenation and oxidation of cytochrome-c-oxidase using a liquid blood phantom

Autores: Charly Caredda, Frédéric Lange, Ilias Tachtsidis, Bruno Montcel
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX;, Edición 126280Q, 2023, ISSN 0277-786X
Editor: SPIE

Digital modeling of a heterogeneous and dynamic brain phantom: application to the choice of an RGB camera for intraoperative functional brain mapping studies

Autores: Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Publicado en: Diffuse Optical Spectroscopy and Imaging IX, 2023
Editor: SPIE
DOI: 10.1117/12.2670750

HyperProbe consortium: innovate tumour neurosurgery with innovative photonic solutions

Autores: Luca Giannoni, Marta Marradi, Marco Marchetti, Duccio Rossi Degl’Innocenti, Ivan Ezhov, Charly Caredda, Arthur Gautheron, Fernand Fort, Fabien Schneider, Moncef Berhouma, Camilla Bonaudo, Thiébaud Picart, Frédéric Lange, Katharina Krischak, et al.
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Edición 126281C, 2023, ISSN 0277-786X
Editor: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2670764

Peer reviewed articles (8)

Learnable real-time inference of molecular composition from diffuse spectroscopy of brain tissue

Autores: Ivan Ezhov, Kevin Scibilia, Luca Giannoni, Florian Kofler, Ivan Iliash, Felix Hsieh, Suprosanna Shit, Charly Caredda, Frédéric Lange, Bruno Montcel, Ilias Tachtsidis, Daniel Rueckert
Publicado en: Journal of Biomedical Optics, Edición 29, 2024, ISSN 1083-3668
Editor: SPIE-Intl Soc Optical Eng
DOI: 10.1117/1.JBO.29.9.093509

Intraoperative identification of functional brain areas with RGB imaging using statistical parametric mapping: Simulation and clinical studies

Autores: Charly Caredda, Eric Van Reeth, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Publicado en: NeuroImage, Edición 278, 2023, ISSN 1053-8119
Editor: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2023.120286

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

Autores: A. Gautheron, J. D. Bernstock, T. Picart, J. Guyotat, P. A. Valdés, B. Montcel
Publicado en: Frontiers in Neuroscience, Edición 18, 2024, ISSN 1662-453X
Editor: Frontiers Media SA
DOI: 10.3389/FNINS.2024.1310282

Cancers

Autores: Thiebaud Picart; Arthur Gautheron; Charly Caredda; Cédric Ray; Laurent Mahieu-Williame; Bruno Montcel; Jacques Guyotat
Publicado en: Fluorescence-Guided Surgical Techniques in Adult Diffuse Low-Grade Gliomas: State-of-the-Art and Emerging Techniques: A Systematic Review, Edición 16(15), 2024, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/CANCERS16152698

Intraoperative Hyperspectral Imaging for Mapping Brain Motor and Sensory Functions With the Measurements of Changes in Hemoglobin Oxygenation and Oxidation of Cytochrome-C-Oxidase

Autores: Charly Caredda, Frédéric Lange, Ilias Tachtsidis, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Publicado en: IEEE Journal of Selected Topics in Quantum Electronics, Edición 31, 2025, ISSN 1077-260X
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSTQE.2025.3531556

Digital instrument simulator to optimize the development of hyperspectral systems: application for intraoperative functional brain mapping

Autores: Caredda, Charly; Lange, Frédéric; Giannoni, Luca; Ezhov, Ivan; Picart, Thiébaud; Guyotat, Jacques; Tachtsidis, Ilias; Montcel, Bruno
Publicado en: Journal of Biomedical Optics, 2024, ISSN 1560-2281
Editor: SPIE
DOI: 10.48550/ARXIV.2406.01217

A priori free spectral unmixing with periodic absorbance changes: application for auto-calibrated intraoperative functional brain mapping

Autores: Charly Caredda, Jérémy E. Cohen, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Publicado en: Biomedical Optics Express, Edición 15, 2023, ISSN 2156-7085
Editor: Optica Publishing Group
DOI: 10.1364/BOE.491292

Transportable hyperspectral imaging setup based on fast, high-density spectral scanning for in situ quantitative biochemical mapping of fresh tissue biopsies

Autores: Luca Giannoni, Marta Marradi, Kevin Scibilia, Ivan Ezhov, Camilla Bonaudo, Angelos Artemiou, Anam Toaha, Frédéric Lange, Charly Caredda, Bruno Montcel, Alessandro Della Puppa, Ilias Tachtsidis, Daniel Rückert, and Francesco Saverio Pavone
Publicado en: Journal of Biomedical Optics, Edición 29(9), 2024, ISSN 1560-2281
Editor: SPIE
DOI: 10.48550/arXiv.2405.20765