Transforming brain surgery by advancing functional-guided neuronavigational imaging

Información del proyecto

HyperProbe

Identificador del acuerdo de subvención: 101071040

DOI

10.3030/101071040

Fecha de la firma de la CE 8 Julio 2022

Fecha de inicio 1 Octubre 2022

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 3 548 325,00

Aportación de la UE

€ 3 360 825,00

Coordinado por

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data sets, microdata, etc (5)

Simple liquid phantom delivery

Delivery of the recipe of a liquid phantom to test the accuracy of HyperProbe1 in the quantification of clinical and optical biomarkers (UCL, DATA, PU, M24).A full dataset of results and a report will also be produced to describe and explain the outcomes.

Digital phantom delivery

Delivery of digital phantom for optimising the final parameters of HyperProbe1 UCL DATA PU M12A full dataset of results and a report will also be produced to describe and explain the outcomes

Prototype features definition

Definition of the essential features of the system for the prototype device (EMO, R, PU, M27)A full dataset of results and a report will also be produced to describe and explain the outcomes.

Lab system testing (HyperProbe1)

Preliminary testing and characterisation of laboratory system, HyperProbe1 (UNIFI, DATA, PU, M24)A full dataset of results and a report will also be produced to describe and explain the outcomes.

Image processing pipelines for registration of pre- and intraoperative imaging

Automatic image-processing pipelines for registration of intraoperative and preoperative optical imaging modalities (UCBL, DATA, PU, M24).A full dataset of results and a report will also be produced to describe and explain the outcomes.

Other (1)

Software tools for deep learning-based reconstruction

Delivery of software tools for deep learning-based reconstruction of optical images and quantitative parameter maps (TUM, OTHER, PU, M24).A piece of software, a full dataset of results and a report will also be produced to describe and explain the outcomes.

Demonstrators, pilots, prototypes (1)

Lab system development (HyperProbe1)

Development of a fullyworking laboratory version of the HyperProbe system UNIFI DEM PU M12A fully working setup and a report will also be produced to describe and explain the outcomes

Documents, reports (1)

Project website and visual identity

Project website and visual identity EIBIR R PU M3

Publicaciones

Conference proceedings (12)

Optical characterisation and study of ex vivo glioma tissue for hyperspectral imaging during neurosurgery

Autores: Luca Giannoni, Camilla Bonaudo, Marta Marradi, Alessandro Della Puppa, Francesco S. Pavone
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Edición 1262829, 2023, ISSN 0277-786X
Editor: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2670854

HyperProbe consortium: transforming neuronavigation in glioma surgery with hyperspectral imaging

Autores: Luca Giannoni, Anam Toaha, Marta Marradi, Duccio Rossi Degl’Innocenti, Ivan Ezhov, Charly Caredda, Arthur Gautheron, Fernand Fort, Fabien Schneider, Moncef Berhouma, Camilla Bonaudo, Frédéric Lange, Angelos Artemiou, Eszter Balázs, et al.
Publicado en: Optica Biophotonics Congress: Biomedical Optics 2024 (Translational, Microscopy, OCT, OTS, BRAIN), Edición TS5B.7, 2024, ISBN 978-1-957171-34-0
Editor: Optica Publishing Group
DOI: 10.1364/TRANSLATIONAL.2024.TS5B.7

Identifying chromophore fingerprints of brain tumor tissue on hyperspectral imaging using principal component analysis

Autores: Ivan Ezhov, Luca Giannoni, Suprosanna Shit, Frederic Lange, Florian Kofler, Bjoern Menze, Ilias Tachtsidis, Daniel Rueckert
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Edición 1262826, 2023, ISSN 0277-786X
Editor: SPIE
DOI: 10.48550/arXiv.2301.05233

Pixel-wise and real-time estimation of optical mean path length using deep learning: application for intraoperative functional brain mapping

Autores: Charly Caredda, Ivan Ezhov, Michaël Sdika, Frédéric Lange, Luca Giannoni, Ilias Tachtsidis, Bruno Montcel
Publicado en: Clinical Biophotonics III, 2024
Editor: SPIE
DOI: 10.1117/12.3016632

Advancing Neuroscience Diagnostics: A Hyperspectral Imaging System for Real-Time Biochemical Insights into Brain Tissue

Autores: Anam Toaha, Pietro Ricci, Louis Chessel, Dorotea Nardini, Luca Giannoni, Ilias Tachtsidis, Francesco Pavone
Publicado en: European Conferences on Biomedical Optics 2025, 2025
Editor: Optica Publishing Group
DOI: 10.1364/ECBO.2025.TU2A.25

Addressing Annotation Scarcity in Hyperspectral Brain Image Segmentation with Unsupervised Domain Adaptation

Autores: Tim Mach, Daniel Rueckert, Alex Berger, Laurin Lux, Ivan Ezhov
Publicado en: 2025 21st International Symposium on Biomedical Image Processing and Analysis (SIPAIM), Edición 11283255, 2025, ISSN 2694-2798
Editor: IEEE
DOI: 10.1109/SIPAIM.2025.11283255

A digital instrument simulator to optimize the development of hyperspectral imaging system for neurosurgery.

Autores: Lange, F., Giannoni, L., Fort, F., Caredda, C., Montcel, B., & Tachtsidis, I.
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX;, Edición 126282C, 2023, ISSN 0277-786X
Editor: SPIE

A hyperspectral imaging system for meningioma grade discrimination

Autores: Pietro Ricci, Camilla Bonaudo, Ivan Ezhov, Anam Toaha, Dorotea Nardini, Louis Chessel, Luca Giannoni, Ilias Tachtsidis, Francesco S. Pavone
Publicado en: Translational Biophotonics: Diagnostics and Therapeutics IV, 2025
Editor: SPIE
DOI: 10.1117/12.3098477

A novel hyperspectral imaging tool for preclinical and translational investigations of brain tissue physiology and pathology

Autores: Luca Giannoni, Anam Toaha, Marta Marradi, Camilla Bonaudo, Alessandro Della Puppa, and Francesco S. Pavone
Publicado en: Optica Biophotonics Congress: Biomedical Optics 2024 (Translational, Microscopy, OCT, OTS, BRAIN), Edición JD6A.4, 2024, ISBN 978-1-957171-34-0
Editor: Optica Publishing Group

Evaluation of hyperspectral imaging measurements of changes in hemoglobin oxygenation and oxidation of cytochrome-c-oxidase using a liquid blood phantom

Autores: Charly Caredda, Frédéric Lange, Ilias Tachtsidis, Bruno Montcel
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX;, Edición 126280Q, 2023, ISSN 0277-786X
Editor: SPIE

Digital modeling of a heterogeneous and dynamic brain phantom: application to the choice of an RGB camera for intraoperative functional brain mapping studies

Autores: Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Publicado en: Diffuse Optical Spectroscopy and Imaging IX, 2023
Editor: SPIE
DOI: 10.1117/12.2670750

HyperProbe consortium: innovate tumour neurosurgery with innovative photonic solutions

Autores: Luca Giannoni, Marta Marradi, Marco Marchetti, Duccio Rossi Degl’Innocenti, Ivan Ezhov, Charly Caredda, Arthur Gautheron, Fernand Fort, Fabien Schneider, Moncef Berhouma, Camilla Bonaudo, Thiébaud Picart, Frédéric Lange, Katharina Krischak, et al.
Publicado en: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Edición 126281C, 2023, ISSN 0277-786X
Editor: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2670764

Peer reviewed articles (11)

Learnable real-time inference of molecular composition from diffuse spectroscopy of brain tissue

Autores: Ivan Ezhov, Kevin Scibilia, Luca Giannoni, Florian Kofler, Ivan Iliash, Felix Hsieh, Suprosanna Shit, Charly Caredda, Frédéric Lange, Bruno Montcel, Ilias Tachtsidis, Daniel Rueckert
Publicado en: Journal of Biomedical Optics, Edición 29, 2024, ISSN 1083-3668
Editor: SPIE-Intl Soc Optical Eng
DOI: 10.1117/1.JBO.29.9.093509

Intraoperative identification of functional brain areas with RGB imaging using statistical parametric mapping: Simulation and clinical studies

Autores: Charly Caredda, Eric Van Reeth, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Publicado en: NeuroImage, Edición 278, 2023, ISSN 1053-8119
Editor: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2023.120286

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

Autores: A. Gautheron, J. D. Bernstock, T. Picart, J. Guyotat, P. A. Valdés, B. Montcel
Publicado en: Frontiers in Neuroscience, Edición 18, 2024, ISSN 1662-453X
Editor: Frontiers Media SA
DOI: 10.3389/FNINS.2024.1310282

Cancers

Autores: Thiebaud Picart; Arthur Gautheron; Charly Caredda; Cédric Ray; Laurent Mahieu-Williame; Bruno Montcel; Jacques Guyotat
Publicado en: Fluorescence-Guided Surgical Techniques in Adult Diffuse Low-Grade Gliomas: State-of-the-Art and Emerging Techniques: A Systematic Review, Edición 16(15), 2024, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/CANCERS16152698

Intraoperative Hyperspectral Imaging for Mapping Brain Motor and Sensory Functions With the Measurements of Changes in Hemoglobin Oxygenation and Oxidation of Cytochrome-C-Oxidase

Autores: Charly Caredda, Frédéric Lange, Ilias Tachtsidis, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Publicado en: IEEE Journal of Selected Topics in Quantum Electronics, Edición 31, 2025, ISSN 1077-260X
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSTQE.2025.3531556

Digital instrument simulator to optimize the development of hyperspectral systems: application for intraoperative functional brain mapping

Autores: Caredda, Charly; Lange, Frédéric; Giannoni, Luca; Ezhov, Ivan; Picart, Thiébaud; Guyotat, Jacques; Tachtsidis, Ilias; Montcel, Bruno
Publicado en: Journal of Biomedical Optics, 2024, ISSN 1560-2281
Editor: SPIE
DOI: 10.48550/ARXIV.2406.01217

Versatile and comprehensive hyperspectral imaging tool for molecular neuronavigation: a case study on cerebral gliomas

Autores: Dorotea Nardini, Anam Toaha, Camilla Bonaudo, Ivan Ezhov, Angelos Artemiou, Manuel Camelia, Filippo Nozzoli, Luca Giannoni, Ilias Tachtsidis, Alessandro Della Puppa, Daniel Rueckert, Pietro Ricci, Francesco Pavone
Publicado en: Journal of Biomedical Optics, Edición 30, 2025, ISSN 1083-3668
Editor: SPIE-Intl Soc Optical Eng
DOI: 10.1117/1.JBO.30.12.126007

A priori free spectral unmixing with periodic absorbance changes: application for auto-calibrated intraoperative functional brain mapping

Autores: Charly Caredda, Jérémy E. Cohen, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Publicado en: Biomedical Optics Express, Edición 15, 2023, ISSN 2156-7085
Editor: Optica Publishing Group
DOI: 10.1364/BOE.491292

A Label‐Free Hyperspectral Imaging Device for Ex Vivo Characterization and Grading of Meningioma Tissues

Autores: Pietro Ricci, Camilla Bonaudo, Ivan Ezhov, Anam Toaha, Dorotea Nardini, Manuel Camelia, Federica Lucidi, Filippo Nozzoli, Tim Mach, Ilias Tachtsidis, Daniel Rueckert, Alessandro Della Puppa, Luca Giannoni, Francesco S. Pavone
Publicado en: Journal of Biophotonics, Edición 19, 2026, ISSN 1864-063X
Editor: Wiley
DOI: 10.1002/JBIO.202500374

Transportable hyperspectral imaging setup based on fast, high-density spectral scanning for in situ quantitative biochemical mapping of fresh tissue biopsies

Autores: Luca Giannoni, Marta Marradi, Kevin Scibilia, Ivan Ezhov, Camilla Bonaudo, Angelos Artemiou, Anam Toaha, Frédéric Lange, Charly Caredda, Bruno Montcel, Alessandro Della Puppa, Ilias Tachtsidis, Daniel Rückert, and Francesco Saverio Pavone
Publicado en: Journal of Biomedical Optics, Edición 29(9), 2024, ISSN 1560-2281
Editor: SPIE
DOI: 10.48550/arXiv.2405.20765

Lecture Notes in Computer Science

Autores: Martin Hartenberger, Huzeyfe Ayaz, Fatih Ozlugedik, Charly Caredda, Luca Giannoni, Frédéric Lange, Laurin Lux, Jonas Weidner, Alex Berger, Florian Kofler, Martin Menten, Bruno Montcel, Ilias Tachtsidis, Daniel Rueckert, Ivan Ezhov
Publicado en: Lecture Notes in Computer Science, Computational Mathematics Modeling in Cancer Analysis, 2025, ISSN 0302-9743
Editor: Springer Verlag
DOI: 10.1007/978-3-032-06624-4_5