Transforming brain surgery by advancing functional-guided neuronavigational imaging

Projektinformationen

HyperProbe

ID Finanzhilfevereinbarung: 101071040

DOI

10.3030/101071040

EK-Unterschriftsdatum 8 Juli 2022

Startdatum 1 Oktober 2022

Enddatum 30 September 2027

Finanziert unter

• The European Innovation Council (EIC)

Gesamtkosten

€ 3 548 325,00

EU-Beitrag

€ 3 360 825,00

Koordiniert durch

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Data sets, microdata, etc (5)

Simple liquid phantom delivery

Delivery of the recipe of a liquid phantom to test the accuracy of HyperProbe1 in the quantification of clinical and optical biomarkers (UCL, DATA, PU, M24).A full dataset of results and a report will also be produced to describe and explain the outcomes.

Digital phantom delivery

Delivery of digital phantom for optimising the final parameters of HyperProbe1 UCL DATA PU M12A full dataset of results and a report will also be produced to describe and explain the outcomes

Prototype features definition

Definition of the essential features of the system for the prototype device (EMO, R, PU, M27)A full dataset of results and a report will also be produced to describe and explain the outcomes.

Lab system testing (HyperProbe1)

Preliminary testing and characterisation of laboratory system, HyperProbe1 (UNIFI, DATA, PU, M24)A full dataset of results and a report will also be produced to describe and explain the outcomes.

Image processing pipelines for registration of pre- and intraoperative imaging

Automatic image-processing pipelines for registration of intraoperative and preoperative optical imaging modalities (UCBL, DATA, PU, M24).A full dataset of results and a report will also be produced to describe and explain the outcomes.

Other (1)

Software tools for deep learning-based reconstruction

Delivery of software tools for deep learning-based reconstruction of optical images and quantitative parameter maps (TUM, OTHER, PU, M24).A piece of software, a full dataset of results and a report will also be produced to describe and explain the outcomes.

Demonstrators, pilots, prototypes (1)

Lab system development (HyperProbe1)

Development of a fullyworking laboratory version of the HyperProbe system UNIFI DEM PU M12A fully working setup and a report will also be produced to describe and explain the outcomes

Documents, reports (1)

Project website and visual identity

Project website and visual identity EIBIR R PU M3

Veröffentlichungen

Conference proceedings (9)

Optical characterisation and study of ex vivo glioma tissue for hyperspectral imaging during neurosurgery

Autoren: Luca Giannoni, Camilla Bonaudo, Marta Marradi, Alessandro Della Puppa, Francesco S. Pavone
Veröffentlicht in: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Ausgabe 1262829, 2023, ISSN 0277-786X
Herausgeber: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2670854

HyperProbe consortium: transforming neuronavigation in glioma surgery with hyperspectral imaging

Autoren: Luca Giannoni, Anam Toaha, Marta Marradi, Duccio Rossi Degl’Innocenti, Ivan Ezhov, Charly Caredda, Arthur Gautheron, Fernand Fort, Fabien Schneider, Moncef Berhouma, Camilla Bonaudo, Frédéric Lange, Angelos Artemiou, Eszter Balázs, et al.
Veröffentlicht in: Optica Biophotonics Congress: Biomedical Optics 2024 (Translational, Microscopy, OCT, OTS, BRAIN), Ausgabe TS5B.7, 2024, ISBN 978-1-957171-34-0
Herausgeber: Optica Publishing Group
DOI: 10.1364/TRANSLATIONAL.2024.TS5B.7

Identifying chromophore fingerprints of brain tumor tissue on hyperspectral imaging using principal component analysis

Autoren: Ivan Ezhov, Luca Giannoni, Suprosanna Shit, Frederic Lange, Florian Kofler, Bjoern Menze, Ilias Tachtsidis, Daniel Rueckert
Veröffentlicht in: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Ausgabe 1262826, 2023, ISSN 0277-786X
Herausgeber: SPIE
DOI: 10.48550/arXiv.2301.05233

Pixel-wise and real-time estimation of optical mean path length using deep learning: application for intraoperative functional brain mapping

Autoren: Charly Caredda, Ivan Ezhov, Michaël Sdika, Frédéric Lange, Luca Giannoni, Ilias Tachtsidis, Bruno Montcel
Veröffentlicht in: Clinical Biophotonics III, 2024
Herausgeber: SPIE
DOI: 10.1117/12.3016632

A digital instrument simulator to optimize the development of hyperspectral imaging system for neurosurgery.

Autoren: Lange, F., Giannoni, L., Fort, F., Caredda, C., Montcel, B., & Tachtsidis, I.
Veröffentlicht in: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX;, Ausgabe 126282C, 2023, ISSN 0277-786X
Herausgeber: SPIE

A novel hyperspectral imaging tool for preclinical and translational investigations of brain tissue physiology and pathology

Autoren: Luca Giannoni, Anam Toaha, Marta Marradi, Camilla Bonaudo, Alessandro Della Puppa, and Francesco S. Pavone
Veröffentlicht in: Optica Biophotonics Congress: Biomedical Optics 2024 (Translational, Microscopy, OCT, OTS, BRAIN), Ausgabe JD6A.4, 2024, ISBN 978-1-957171-34-0
Herausgeber: Optica Publishing Group

Evaluation of hyperspectral imaging measurements of changes in hemoglobin oxygenation and oxidation of cytochrome-c-oxidase using a liquid blood phantom

Autoren: Charly Caredda, Frédéric Lange, Ilias Tachtsidis, Bruno Montcel
Veröffentlicht in: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX;, Ausgabe 126280Q, 2023, ISSN 0277-786X
Herausgeber: SPIE

Digital modeling of a heterogeneous and dynamic brain phantom: application to the choice of an RGB camera for intraoperative functional brain mapping studies

Autoren: Charly Caredda, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Veröffentlicht in: Diffuse Optical Spectroscopy and Imaging IX, 2023
Herausgeber: SPIE
DOI: 10.1117/12.2670750

HyperProbe consortium: innovate tumour neurosurgery with innovative photonic solutions

Autoren: Luca Giannoni, Marta Marradi, Marco Marchetti, Duccio Rossi Degl’Innocenti, Ivan Ezhov, Charly Caredda, Arthur Gautheron, Fernand Fort, Fabien Schneider, Moncef Berhouma, Camilla Bonaudo, Thiébaud Picart, Frédéric Lange, Katharina Krischak, et al.
Veröffentlicht in: Proc. SPIE 12628, Diffuse Optical Spectroscopy and Imaging IX, Ausgabe 126281C, 2023, ISSN 0277-786X
Herausgeber: Society of Photo-Optical Instrumentation Engineers (SPIE)
DOI: 10.1117/12.2670764

Peer reviewed articles (8)

Learnable real-time inference of molecular composition from diffuse spectroscopy of brain tissue

Autoren: Ivan Ezhov, Kevin Scibilia, Luca Giannoni, Florian Kofler, Ivan Iliash, Felix Hsieh, Suprosanna Shit, Charly Caredda, Frédéric Lange, Bruno Montcel, Ilias Tachtsidis, Daniel Rueckert
Veröffentlicht in: Journal of Biomedical Optics, Ausgabe 29, 2024, ISSN 1083-3668
Herausgeber: SPIE-Intl Soc Optical Eng
DOI: 10.1117/1.JBO.29.9.093509

Intraoperative identification of functional brain areas with RGB imaging using statistical parametric mapping: Simulation and clinical studies

Autoren: Charly Caredda, Eric Van Reeth, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Veröffentlicht in: NeuroImage, Ausgabe 278, 2023, ISSN 1053-8119
Herausgeber: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2023.120286

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review

Autoren: A. Gautheron, J. D. Bernstock, T. Picart, J. Guyotat, P. A. Valdés, B. Montcel
Veröffentlicht in: Frontiers in Neuroscience, Ausgabe 18, 2024, ISSN 1662-453X
Herausgeber: Frontiers Media SA
DOI: 10.3389/FNINS.2024.1310282

Cancers

Autoren: Thiebaud Picart; Arthur Gautheron; Charly Caredda; Cédric Ray; Laurent Mahieu-Williame; Bruno Montcel; Jacques Guyotat
Veröffentlicht in: Fluorescence-Guided Surgical Techniques in Adult Diffuse Low-Grade Gliomas: State-of-the-Art and Emerging Techniques: A Systematic Review, Ausgabe 16(15), 2024, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/CANCERS16152698

Intraoperative Hyperspectral Imaging for Mapping Brain Motor and Sensory Functions With the Measurements of Changes in Hemoglobin Oxygenation and Oxidation of Cytochrome-C-Oxidase

Autoren: Charly Caredda, Frédéric Lange, Ilias Tachtsidis, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Veröffentlicht in: IEEE Journal of Selected Topics in Quantum Electronics, Ausgabe 31, 2025, ISSN 1077-260X
Herausgeber: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSTQE.2025.3531556

Digital instrument simulator to optimize the development of hyperspectral systems: application for intraoperative functional brain mapping

Autoren: Caredda, Charly; Lange, Frédéric; Giannoni, Luca; Ezhov, Ivan; Picart, Thiébaud; Guyotat, Jacques; Tachtsidis, Ilias; Montcel, Bruno
Veröffentlicht in: Journal of Biomedical Optics, 2024, ISSN 1560-2281
Herausgeber: SPIE
DOI: 10.48550/ARXIV.2406.01217

A priori free spectral unmixing with periodic absorbance changes: application for auto-calibrated intraoperative functional brain mapping

Autoren: Charly Caredda, Jérémy E. Cohen, Laurent Mahieu-Williame, Raphaël Sablong, Michaël Sdika, Fabien C. Schneider, Thiébaud Picart, Jacques Guyotat, Bruno Montcel
Veröffentlicht in: Biomedical Optics Express, Ausgabe 15, 2023, ISSN 2156-7085
Herausgeber: Optica Publishing Group
DOI: 10.1364/BOE.491292

Transportable hyperspectral imaging setup based on fast, high-density spectral scanning for in situ quantitative biochemical mapping of fresh tissue biopsies

Autoren: Luca Giannoni, Marta Marradi, Kevin Scibilia, Ivan Ezhov, Camilla Bonaudo, Angelos Artemiou, Anam Toaha, Frédéric Lange, Charly Caredda, Bruno Montcel, Alessandro Della Puppa, Ilias Tachtsidis, Daniel Rückert, and Francesco Saverio Pavone
Veröffentlicht in: Journal of Biomedical Optics, Ausgabe 29(9), 2024, ISSN 1560-2281
Herausgeber: SPIE
DOI: 10.48550/arXiv.2405.20765