Project description
Skin-inspired living materials
Compared to conventional materials, biomaterials encountered in living organisms are characterised by specific architecture, organisation and often exhibit multiple functions. Εngineered living materials (ELMs) have emerged at the cornerstone of synthetic biology and material science to produce materials with improved functions because of the living organisms within them. Funded by the European Innovation Council, the NextSkins project is inspired by the structure/function of the many layers of skin. Researchers will mimic the specialised skin arrangement to make two engineered living materials: one with a therapeutic function to treat skin diseases and one with a regenerative function to be used as a protective garment in sports.
Objective
Skin is a living interface with layers of specialised functions (sensing, regeneration, protection). The level of complexity in skins is currently unreached in engineered living materials (ELMs). Here we will create skin-inspired ELMs with layers with living cells, specialised properties and functions. Our living skins are based on a grown matrix hosting engineered multicellular consortia that build and functionalise different layers. Spatiotemporal patterning is realised by genetic control and the physicochemical properties of cells and biomolecules. Our aim is to generate platform technologies to advance biological ELMs and make two proof-of-concept engineered living skins with different applications:
We will fabricate a self-encapsulated Living Therapeutic Skin (LTS) made of a bacterial cellulose hydrogel matrix with sense-and-respond cells. LTS will have an interactive layer with sensing functions, a core layer for responsive living cells, and a barrier layer for biocontainment and hydration. An example LTS will be designed to sense pathogenic skin bacteria in eczema and release biosynthesised therapeutic molecules.
A dry and tough Living Regenerative Skin (LRS) consisting of biomineralized biopolymers hosting bacterial spores will be fabricated as an alternative to traditional inert materials (ceramics, plastics) in protective garments. The LRS biomineralized core will arrange in microscale layers, like tough biominerals in nature (nacre, bone, dentin). LRS will be encapsulated in an activator shell, engineered to prevent water penetration and to memorize local mechanical experience, giving local self-reinforcement of mechanically stressed regions, a unique property compared to current materials and other ELMs.
As a powerful strategy to accelerate the adoption of our living materials in society, we will systematically involve the potential end-users and designers in our research for the materials and product development to happen in synergy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences clinical medicine dermatology
- natural sciences biological sciences biochemistry biomolecules
- engineering and technology materials engineering ceramics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2021-PATHFINDERCHALLENGES-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2628 CN DELFT
Netherlands
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