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Peripheral Biomarker Based Combinatorial Early Diagnostics for Dementia

Objective

CombiDiag DN aims to develop an AI-data-driven peripheral biomarker based combinatorial diagnostic protocol for early stages of Alzheimers disease (AD), a major form of dementia, and to train a new generation of fellows for this interdisciplinary field. Dementia, a devastating disease of older age, is the challenge of our lifetime and one of the Societal Challenges listed by the UN Sustainable Development Goals and Horizon Europe. CombiDiag responds to this challenge to establish a much-needed DN to carry out an integrated study of minimally invasive and cost-effective peripheral biomarkers, including body fluid markers from blood, urine and saliva, and digital markers from speech, motor functions and sleep for developing the combinatorial early AD diagnostics. The consortium comprises nine academic and eight non-academic institutions across Europe, USA, Canada, and China. It synergises leading academic and industrial experts worldwide to build a triple-i research and training platform for the training of a new generation of Fellows to take early AD diagnostic research to a new level. Fellows will be trained under the Vitae Researcher Development Framework innovatively combined with the CombiDiag platform for triple-i scientific and transferable skills as well as personal quality, creative thinking, and business mind-set. The DN has a highly innovative research programme for the discovery of peripheral AD biomarkers, detection techniques, AI/data driven technology, clinical validation, and integration into trial designs. The advances in CombiDiag research will enable a case finding tool at primary care level for helping achieve improved drug discoveries, disease-modifying treatments, preventive strategies and care provision for AD. CombiDiag will deliver 10 highly-skilled, creative and entrepreneurial Fellows, setting them on a path to successful careers in academia or industry to ensure that the medical and societal challenges imposed by AD are met.

Coordinator

UNIVERSITATSMEDIZIN ROSTOCK
Net EU contribution
€ 260 539,20
Address
Schillingallee 35
18055 Rostock
Germany

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Region
Mecklenburg-Vorpommern Mecklenburg-Vorpommern Rostock, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Participants (7)

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 260 539,20
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
No data
NORDIC BIOSCIENCE A/S
Denmark
Net EU contribution
€ 301 788,00
Address
Herlev Hovedgade 205-207
2730 Herlev

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
FIRALIS
France
Net EU contribution
€ 282 693,60
Address
Rue Du Fort 35
68330 Huningue

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Grand Est Alsace Haut-Rhin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
Net EU contribution
€ 259 437,60
Address
Piazzale Aldo Moro 5
00185 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITAET ROSTOCK
Germany
Net EU contribution
€ 260 539,20
Address
Universitatsplatz 1
18055 Rostock

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
No data
INSTITUTO DE SALUD CARLOS III
Spain
Net EU contribution
€ 251 971,20
Address
Monforte De Lemos 5
28029 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
No data
UNIVERSITE COTE D'AZUR
France
Net EU contribution
€ 282 693,60
Address
Grand Chateau 28 Avenue Valrose
06100 Nice

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Region
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Alpes-Maritimes
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Partners (12)

CAPITAL MEDICAL UNIVERSITY
China
Net EU contribution
€ 0,00
Address
10 Youanmenwai
Beijing

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Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITY OF WATERLOO
Canada
Net EU contribution
€ 0,00
Address
200 University Avenue West
N2L 3G1 Waterloo

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Activity type
Higher or Secondary Education Establishments
Other funding
No data
Quanterix Corporation
United States
Net EU contribution
€ 0,00
Address
113 Hartwell Avenue
02421 Lexington

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
No data
ALZHEIMER EUROPE
Luxembourg
Net EU contribution
€ 0,00
Address
Rue Dicks 14
1417 Luxembourg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Luxembourg Luxembourg Luxembourg
Activity type
Other
Other funding
No data
BGI SHENZHEN LIFE SCIENCE RESEARCH INSTITUTION
China
Net EU contribution
€ 0,00
Address
Building 11, Beishan Industrial Zone Yantian District
518083 Shenzhen

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Activity type
Research Organisations
Other funding
No data
D Young & Co LLP
United Kingdom
Net EU contribution
€ 0,00
Address
Briton House, 10-12 Briton Street
SO14 3EB Southampton

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Region
South East (England) Hampshire and Isle of Wight Southampton
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
G.TEC MEDICAL ENGINEERING GMBH
Austria
Net EU contribution
€ 0,00
Address
Sierningstrasse 14
4521 Schiedlberg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Westösterreich Oberösterreich Steyr-Kirchdorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
THE UNIVERSITY OF READING
United Kingdom
Net EU contribution
€ 0,00
Address
Whiteknights Campus Whiteknights House
RG6 6AH Reading

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITY OF PLYMOUTH
United Kingdom
Net EU contribution
€ 0,00
Address
Drake Circus
PL4 8AA Plymouth

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Region
South West (England) Devon Plymouth
Activity type
Higher or Secondary Education Establishments
Other funding
No data
DANMARKS TEKNISKE UNIVERSITET
Denmark
Net EU contribution
€ 0,00
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITAT DES SAARLANDES
Germany
Net EU contribution
€ 0,00
Address
Campus
66123 Saarbrucken

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Region
Saarland Saarland Regionalverband Saarbrücken
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Net EU contribution
€ 0,00
Address
Avenida De Seneca 2
28040 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Other funding
No data