Peripheral Biomarker Based Combinatorial Early Diagnostics for Dementia

Project Information

CombiDiag

Grant agreement ID: 101071485

DOI

10.3030/101071485

EC signature date 28 June 2022

Start date 1 February 2023

End date 31 July 2027

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 2 160 201,60

Coordinated by

UNIVERSITATSMEDIZIN ROSTOCK
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (1)

Web demonstration of CombiDiag data sharing platform No. 5

Web demonstration of CombiDiag data sharing platform

Websites, patent fillings, videos etc. (1)

CombiDiag network website

Publications

Peer reviewed articles (18)

Advancing point-of-care testing with nanomaterials-based screen-printing electrodes

Author(s): Sophia Nazir
Published in: Sensors International, Issue 6, 2025, ISSN 2666-3511
Publisher: Elsevier BV
DOI: 10.1016/J.SINTL.2025.100328

Association of salivary lactoferrin, Porphyromoras gingivalis and stress hormone levels in patients with periodontitis: a pilot study

Author(s): Desireé Antequera, Elena Buetas, Sandra García-Esteban, Deborah Romualdi, Laura Carrero, Cristina Municio, Alex Mira, Eva Carro
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1681095

Porphyromonas gingivalis in Alzheimer’s disease: Association with salivary lactoferrin and inflammatory response

Author(s): Desiree Antequera, Laura Carrero, Deborah Romualdi, Elena Buetas, Ines Garcia-Consuegra, Jose L. Cantero, Alex Mira, Cristina Municio, Eva Carro
Published in: Biomedicine & Pharmacotherapy, Issue 196, 2026, ISSN 0753-3322
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPHA.2026.119112

Predicting the risk of cognitive decline and speech impairment in the preclinical stage of Alzheimer's disease using structural MRI

Author(s): Qingyue Li, Alexandra König, Nicklas Linz, Fedor Levin, Martin Dyrba, Annika Spottke, Björn Falkenburger, Christoph Laske, Emrah Düzel, Frank Jessen, Inga Zerr, Jens Wiltfang, Josef Priller, Michael T. Heneka, Michael Wagner, Stefan Teipel, Stefanie Köhler
Published in: Alzheimer's & Dementia, Issue 20, 2025, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.087212

Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer’s disease

Author(s): Qingyue Li, Zampeta-Sofia Alexopoulou, Martin Dyrba, Elisa Mallick, Johannes Tröger, Eike Spruth, Slawek Altenstein, Claudia Bartels, Wenzel Glanz, Enise I. Incesoy, Michaela Butryn, Ingo Kilimann, Sebastian Sodenkamp, Franziska Maier, Ayda Rostamzadeh, Antje Osterrath, Josef Priller, Anja Schneider, Jens Wiltfang, Christoph Laske, Björn Falkenburger, Michael Wagner, Emrah Duezel, Annika Spottke, Gabor C. Petzold, Frank Jessen, Alexandra König, Stefanie Köhler, Stefan Teipel, null null
Published in: Alzheimer's Research & Therapy, Issue 18, 2026, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-026-01993-X

Leveraging Digital Speech Features for Early Identification of Alzheimer's Disease: Associations with structural and functional brain changes over time

Author(s): Qingyue Li, Stefanie Köhler, Alexandra König, Martin Dyrba, Zampeta‐Sofia Alexopoulou, Elisa Mallick, Nicklas Linz, Anja Schneider, Annika Spottke, Björn Falkenburger, Christoph Laske, Emrah Düzel, Frank Jessen, Inga Zerr, Jens Wiltfang, Josef Priller, Luca Kleineidam, Melina Stark, Michael Wagner, Gabor C Petzold, Fedor Levin, Stefan Teipel
Published in: Alzheimer's & Dementia, Issue 21, 2026, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ70857_098534

Salivary Lactoferrin Levels and Polymorphisms in Down Syndrome Individuals with Periodontitis

Author(s): Lucía Sande López, Eliane García-Mato, Alicia de Coo, Raquel Cruz, Desireé Antequera, Pedro Diz, Eva Carro, Berta Rivas
Published in: Journal of Clinical Medicine, Issue 14, 2025, ISSN 2077-0383
Publisher: MDPI AG
DOI: 10.3390/JCM14061815

Mapping Associations Between the Severity of Neuropsychiatric Symptoms and Automatically Extracted Free‐Speech Features

Author(s): Zampeta‐Sofia Alexopoulou, Qingyue Li, Stefanie Köhler, Elisa Mallick, Johannes Tröger, Josef Priller, Annika Spottke, Björn Falkenburger, Melina Stark, Luca Kleineidam, Jens Wiltfang, Inga Zerr, Frank Jessen, Emrah Düzel, Michael Wagner, Christoph Laske, Stefan Teipel, Valeria Manera, Alexandra König
Published in: Alzheimer's & Dementia, Issue 21, 2026, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ70856_098535

Salivary biomarkers: The early diagnosis of Alzheimer's disease

Author(s): Sophia Nazir
Published in: AGING MEDICINE, Issue 7, 2024, ISSN 2475-0360
Publisher: Wiley
DOI: 10.1002/AGM2.12282

Abnormal electroencephalographic rhythms from quiet wakefulness to light sleep in Alzheimer’s disease patients with mild cognitive impairment

Author(s): Enrico Michele Salamone, Matteo Carpi, Giuseppe Noce, Claudio Del Percio, Susanna Lopez, Roberta Lizio, Dharmendra Jakhar, Ali Eldellaa, Veronica Henao Isaza, Burcu Bölükbaş, Andrea Soricelli, Marco Salvatore, Bahar Güntekin, Görsev Yener, Federico Massa, Dario Arnaldi, Francesco Famà, Matteo Pardini, Raffaele Ferri, Michele Salemi, Bartolo Lanuzza, Fabrizio Stocchi, Laura Vacca, Chiara Coletti, Moira Marizzoni, John Paul Taylor, Lutfu Hanoğlu, Nesrin Helvacı Yılmaz, İlayda Kıyı, Hilal Kula, Giovanni B. Frisoni, Sofia Cuoco, Paolo Barone, Anita D’Anselmo, Laura Bonanni, Roberta Biundo, Fabrizia D’Antonio, Giuseppe Bruno, Franco Giubilei, Angelo Antonini, Claudio Babiloni
Published in: Clinical Neurophysiology, Issue 171, 2025, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/J.CLINPH.2025.01.012

Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia

Author(s): Jonathan D. Rohrer, Ione O.C. Woollacott, Katrina M. Dick, Emilie Brotherhood, Elizabeth Gordon, Alexander Fellows, Jamie Toombs, Ronald Druyeh, M. Jorge Cardoso, Sebastien Ourselin, Jennifer M. Nicholas, Niklas Norgren, Simon Mead, Ulf Andreasson, Kaj Blennow, Jonathan M. Schott, Nick C. Fox, Jason D. Warren, Henrik Zetterberg
Published in: Neurology, Issue 87, 2024, ISSN 0028-3878
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/WNL.0000000000003154

Associations Between Speech‐based Biomarkers of Cognition and Traditional Neuropsychological Assessments in a Preclinical AD Cohort

Author(s): Zampeta‐Sofia Alexopoulou, Stefanie Köhler, Johannes Tröger, Elisa Mallick, Nicklas Linz, Josef Priller, Anja Schneider, Klaus Fließbach, Björn Falkenburger, Jens Wiltfang, Inga Zerr, Frank Jessen, Thomas Klockgether, Emrah Düzel, Annika Spottke, Michael Wagner, Christoph Laske, Valeria Manera, Stefan Teipel, Alexandra König
Published in: Alzheimer's & Dementia, Issue 20, 2025, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.084094

Abnormal periodic and aperiodic resting-state electroencephalographic markers in Lewy body and Alzheimer’s diseases with cognitive decline

Author(s): Matteo Carpi, Antonio Pio Afragola, Mina De Bartolo, Susanna Lopez, Burcu Bölükbaş, Claudio Del Percio, Veronica Henao Isaza, Roberta Lizio, Giuseppe Noce, Lorenc Barjami, Filippo Carducci, Andrea Soricelli, Marco Salvatore, Franco Giubilei, Bahar Güntekin, Görsev Yener, Federico Massa, Dario Arnaldi, Francesco Famà, Matteo Pardini, Raffaele Ferri, Bartolo Lanuzza, Fabrizio Stocchi, Laura Vacca, Chiara Coletti, Moira Marizzoni, John Paul Taylor, Lutfu Hanoğlu, Harun Yırıkoğulları, Giovanni B. Frisoni, Sofia Cuoco, Paolo Barone, Marianna Amboni, Arianna Cappiello, Laura Bonanni, Anita D’Anselmo, Roberta Biundo, Simone Cauzzo, Eleonora Fiorenzato, Angelo Antonini, Fabrizia D’Antonio, Giuseppe Bruno, Francesco Infarinato, Paola Romano, Simone Marziali, Maria Francesca De Pandis, Claudio Babiloni
Published in: GeroScience, 2026, ISSN 2509-2723
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S11357-026-02325-5

Salivary lactoferrin levels in Down Syndrome: a case-control study

Author(s): Desireé Antequera, Lucía Sande, Eliane García Mato, Deborah Romualdi, Laura Carrero, Cristina Municio, Pedro Diz, Eva Carro
Published in: Brain, Behavior, & Immunity - Health, Issue 46, 2025, ISSN 2666-3546
Publisher: Elsevier BV
DOI: 10.1016/J.BBIH.2025.100999

Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer’s disease

Author(s): Julia R. Bacci, Stamatia Karagianni, Zampeta-Sofia Alexopoulou, Shirine Moukaled, Claudia Tato-Fernández, Prithvi Arunachalam, Aram Aslanyan, Sandar Aye, Ana Sabsil Lopez Rocha, Monica Crugel, Ayesha Fawad, Aitana Sogorb-Esteve, Michael Schöll, Alexandra König, Ross W. Paterson
Published in: Alzheimer's Research & Therapy, Issue 18, 2026, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-025-01921-5

Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy Body diseases: An exploratory study

Author(s): Claudio Del Percio, Roberta Lizio, Susanna Lopez, Giuseppe Noce, Dharmendra Jakhar, Matteo Carpi, Burcu Bölükbaş, Andrea Soricelli, Marco Salvatore, Bahar Güntekin, Görsev Yener, Federico Massa, Dario Arnaldi, Francesco Famà, Matteo Pardini, Raffaele Ferri, Michele Salerni, Bartolo Lanuzza, Fabrizio Stocchi, Laura Vacca, Chiara Coletti, Moira Marizzoni, John Paul Taylor, Lutfu Hanoğlu, Nesrin Helvacı Yılmaz, İlayda Kıyı, Yağmur Özbek-İşbitiren, Giovanni B. Frisoni, Sofia Cuoco, Paolo Barone, Anita D'Anselmo, Laura Bonanni, Roberta Biundo, Fabrizia D'Antonio, Giuseppe Bruno, Franco Giubilei, Francesca De Pandis, Rossella Rotondo, Angelo Antonini, Claudio Babiloni
Published in: Neurobiology of Disease, Issue 206, 2025, ISSN 0969-9961
Publisher: Elsevier BV
DOI: 10.1016/J.NBD.2025.106807

Electrochemical Detection of Aβ42 and Aβ40 at Attomolar Scale via Optimised Antibody Loading on Pyr-NHS-Functionalised 3D Graphene Foam Electrodes

Author(s): Muhsin Dogan, Sophia Nazir, David Jenkins, Yinghui Wei, Genhua Pan
Published in: Biosensors, Issue 15, 2025, ISSN 2079-6374
Publisher: MDPI AG
DOI: 10.3390/BIOS15120806

Detecting amyloid positivity from MRI scans using comprehensible convolutional neural networks

Author(s): Fedor Levin, Qingyue Li, Devesh Singh, Katharina Buerger, Klaus Fliessbach, Michael T. Heneka, Luca Kleineidam, Christoph Laske, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Stefan Teipel, Martin Dyrba, null null
Published in: Alzheimer's & Dementia, Issue 20, 2025, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.089044