NEurological MEchanismS of Injury, and Sleep-like cellular dynamics

Project Information

NEMESIS

Grant agreement ID: 101071900

DOI

10.3030/101071900

EC signature date 28 February 2023

Start date 1 October 2023

End date 30 September 2029

Funded under

• European Research Council (ERC)

Total cost

€ 9 927 253,75

EU contribution

€ 9 927 253,75

Coordinated by

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (48)

The correlation of behavioural deficits post-stroke: a trivial issue?

Author(s): Lorenzo Pini, Antonio Luigi Bisogno, Alessandro Salvalaggio, Gordon L Shulman, Maurizio Corbetta
Published in: Brain, Issue 146, 2023, ISSN 0006-8950
Publisher: Oxford University Press (OUP)
DOI: 10.1093/BRAIN/AWAD173

Fluctuation-dissipation theorem and the discovery of distinctive off-equilibrium signatures of brain states

Author(s): Juan Manuel Monti, Yonatan Sanz Perl, Enzo Tagliazucchi, Morten L. Kringelbach, Gustavo Deco
Published in: Physical Review Research, Issue 7, 2025, ISSN 2643-1564
Publisher: American Physical Society (APS)
DOI: 10.1103/PHYSREVRESEARCH.7.013301

Oral Sessions

Published in: Journal of Sleep Research, Issue 33, 2024, ISSN 0962-1105
Publisher: Wiley
DOI: 10.1111/JSR.14290

Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans

Author(s): Simone Russo, Leslie D. Claar, Giulia Furregoni, Lydia C. Marks, Giri Krishnan, Flavia Maria Zauli, Gabriel Hassan, Michela Solbiati, Piergiorgio d’Orio, Ezequiel Mikulan, Simone Sarasso, Mario Rosanova, Ivana Sartori, Maxim Bazhenov, Andrea Pigorini, Marcello Massimini, Christof Koch, Irene Rembado
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-58717-2

Complex harmonics reveal low-dimensional manifolds of critical brain dynamics

Author(s): Gustavo Deco, Yonatan Sanz Perl, Morten L. Kringelbach
Published in: Physical Review E, Issue 111, 2025, ISSN 2470-0045
Publisher: American Physical Society (APS)
DOI: 10.1103/PHYSREVE.111.014410

An integrative, multiscale view on neural theories of consciousness

Author(s): Johan F. Storm, P. Christiaan Klink, Jaan Aru, Walter Senn, Rainer Goebel, Andrea Pigorini, Pietro Avanzini, Wim Vanduffel, Pieter R. Roelfsema, Marcello Massimini, Matthew E. Larkum, Cyriel M.A. Pennartz
Published in: Neuron, Issue 112, 2025, ISSN 0896-6273
Publisher: Elsevier BV
DOI: 10.1016/J.NEURON.2024.02.004

The Thermodynamics of Mind

Author(s): Morten L. Kringelbach, Yonatan Sanz Perl, Gustavo Deco
Published in: Trends in Cognitive Sciences, Issue 28, 2024, ISSN 1364-6613
Publisher: Elsevier BV
DOI: 10.1016/J.TICS.2024.03.009

Complex harmonics reveal low-dimensional manifolds of critical brain dynamics

Author(s): Gustavo Deco, Yonatan Sanz Perl, Morten L. Kringelbach
Published in: Physical Review E, Issue 111, 2025, ISSN 2470-0045
Publisher: American Physical Society (APS)
DOI: 10.1103/PHYSREVE.111.014410

Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder

Author(s): Escrichs, A; Sanz Perl, Y; Fisher, PM; Martínez-Molina, N; G-Guzman, E; Frokjaer, VG; Kringelbach, ML; Knudsen, GM; Deco, G
Published in: Molecular Psychiatry, 2024, ISSN 1476-5578
Publisher: Springer
DOI: 10.1038/S41380-024-02690-7

Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation

Author(s): Paulina Clara Dagnino; Anira Escrichs; Ane López-González; Olivia Gosseries; Jitka Annen; Yonatan Sanz Perl; Morten L. Kringelbach; Steven Laureys; Gustavo Deco
Published in: PLOS Computational Biology, 2023, ISSN 1553-7358
Publisher: San Francisco, CA Public Library of Science
DOI: 10.1101/2023.07.17.549269

Functional hierarchies in brain dynamics characterized by signal reversibility in ferret cortex

Author(s): Sebastián Idesis; Sebastián Geli; Joshua Faskowitz; Jakub Vohryzek; Yonatan Sanz Perl; Florian Pieper; Edgar Galindo‐Leon; Andreas K. Engel; Gustavo Deco
Published in: PLOS Computational Biology, 2023, ISSN 1553-7358
Publisher: San Francisco CA: Public Library of Science
DOI: 10.1371/JOURNAL.PCBI.1011818

Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation

Author(s): Joana Covelo, Martina Cortada, Gianni V. Vinci, Maurizio Mattia, Maria V. Sanchez‐Vives
Published in: Advanced Science, Issue 12, 2025, ISSN 2198-3844
Publisher: Wiley Advanced Science
DOI: 10.1002/ADVS.202414602

Dissociations between spontaneous electroencephalographic features and the perturbational complexity index in the minimally conscious state

Author(s): Silvia Casarotto, Gabriel Hassan, Mario Rosanova, Simone Sarasso, Chiara‐Camilla Derchi, Pietro Davide Trimarchi, Alessandro Viganò, Simone Russo, Matteo Fecchio, Guya Devalle, Jorge Navarro, Marce
Published in: European Journal of Neuroscience, Issue 59, 2025, ISSN 0953-816X
Publisher: Wiley
DOI: 10.1111/EJN.16299

H‐current modulation of cortical Up and Down states

Author(s): Leonardo Dalla Porta, Almudena Barbero‐Castillo, José Manuel Sanchez‐Sanchez, Nathalia Cancino, Maria V. Sanchez‐Vives
Published in: The Journal of Physiology, Issue 603, 2025, ISSN 0022-3751
Publisher: Wiley
DOI: 10.1101/2024.04.05.588281V1

Sleep-like cortical dynamics during wakefulness and their network effects following brain injury

Author(s): Marcello Massimini, Maurizio Corbetta, Maria V. Sanchez-Vives, Thomas Andrillon, Gustavo Deco, Mario Rosanova, Simone Sarasso
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-51586-1

Different hierarchical reconfigurations in the brain by psilocybin and escitalopram for depression

Author(s): Deco, G; Sanz Perl, Y; Johnson, S; Bourke, N; Carhart-Harris, RL; Kringelbach, ML
Published in: Nature Mental Health, 2024, ISSN 2731-6076
Publisher: Springer
DOI: 10.1038/S44220-024-00298-Y

Human brain dynamics are shaped by rare long-range connections over and above cortical geometry

Author(s): Jakub Vohryzek, Yonatan Sanz-Perl, Morten L. Kringelbach, Gustavo Deco
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2415102122

Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions

Author(s): Sebastian Idesis, Gustavo Patow, Michele Allegra, Jakub Vohryzek, Yonatan Sanz Perl, Maria V. Sanchez-Vives, Marcello Massimini, Maurizio Corbetta, Gustavo Deco
Published in: Neurobiology of Disease, Issue 200, 2024, ISSN 0969-9961
Publisher: Elsevier BV
DOI: 10.1016/J.NBD.2024.106613

Assessing mismatch negativity (MMN) and P3b within‐individual sensitivity — A comparison between the local–global paradigm and two specialized oddball sequences

Author(s): Renate Rutiku, Chiara Fiscone, Marcello Massimini, Simone Sarasso
Published in: European Journal of Neuroscience, Issue 59, 2025, ISSN 0953-816X
Publisher: Wiley
DOI: 10.1111/EJN.16302

Non-local Schrödinger diffusion model reveals mechanisms of critical brain dynamics

Author(s): Gustavo Deco, Yonatan Sanz Perl, Morten L. Kringelbach
Published in: Cell Reports Physical Science, Issue 6, 2025, ISSN 2666-3864
Publisher: Elsevier BV
DOI: 10.1016/J.XCRP.2025.102663

Transcranial magnetic vs intracranial electric stimulation: a direct comparison of their effects via scalp EEG recordings

Author(s): Renzo Comolatti, Gabriel Hassan, Ezequiel Mikulan, Simone Russo, Michele A. Colombo, Elisabetta Litterio, Giulia Furregoni, Sasha D'Ambrosio, Matteo Fecchio, Sara Parmigiani, Ivana Sartori, Silvia Casarotto, Andrea Pigorini, Marcello Massimini
Published in: Brain Stimulation, Issue 18, 2025, ISSN 1935-861X
Publisher: Elsevier BV
DOI: 10.1016/J.BRS.2025.07.016

Resting-state functional connectivity guides motor hotspot localization

Author(s): Antonio Luigi Bisogno, Ilaria Mazzonetto, Valentina D’Onofrio, Ester Fusaro, Renzo Manara, Simone Sarasso, Silvia Casarotto, Mario Rosanova, Marcello Massimini, Camillo Porcaro, Lorenzo Pini, Maurizio Corbetta
Published in: Clinical Neurophysiology, Issue 180, 2025, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/J.CLINPH.2025.2111410

European Journal of Neuroscience

Author(s): Rutiku, Renate; Fiscone, Chiara; Massimini, Marcello; Sarasso, Simone
Published in: European Journal of Neuroscience, 2024, ISSN 0953-816X
Publisher: Wiley
DOI: 10.1111/EJN.16302

Are disorders of consciousness ‘dis’connection or ‘dys’connection syndromes?

Author(s): Brian L Edlow, Marcello Massimini
Published in: Brain Communications, Issue 5, 2023, ISSN 2632-1297
Publisher: Oxford University Press (OUP)
DOI: 10.1093/BRAINCOMMS/FCAD328

Non-equilibrium whole-brain dynamics arise from pairwise interactions

Author(s): Sebastian M. Geli, Christopher W. Lynn, Morten L. Kringelbach, Gustavo Deco, Yonatan Sanz Perl
Published in: Cell Reports Physical Science, Issue 6, 2025, ISSN 2666-3864
Publisher: Elsevier BV
DOI: 10.1016/J.XCRP.2025.102464

Controlling target brain regions by optimal selection of input nodes

Author(s): Karan Kabbur Hanumanthappa Manjunatha, Giorgia Baron, Danilo Benozzo, Erica Silvestri, Maurizio Corbetta, Alessandro Chiuso, Alessandra Bertoldo, Samir Suweis, Michele Allegra
Published in: PLOS Computational Biology, Issue 20, 2024, ISSN 1553-7358
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PCBI.1011274

Riemannian Geometry for the Classification of Brain States with Intracortical Brain Recordings

Author(s): Arnau Marin‐Llobet, Sergio Sánchez‐Manso, Arnau Manasanch, Lluc Tresserras, Xinhe Zhang, Yining Hua, Hao Zhao, Melody Torao‐Angosto, Maria V Sanchez‐Vives, Leonardo Dalla Porta
Published in: Advanced Intelligent Systems, 2025, ISSN 2640-4567
Publisher: Wiley
DOI: 10.1002/AISY.202500480

Localizing hidden Interictal Epileptiform Discharges with simultaneous intracerebral and scalp high-density EEG recordings

Author(s): Flavia Maria Zauli, Maria Del Vecchio, Andrea Pigorini, Simone Russo, Marcello Massimini, Ivana Sartori, Francesco Cardinale, Piergiorgio d’Orio, Ezequiel Mikulan
Published in: Journal of Neuroscience Methods, Issue 409, 2024, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/J.JNEUMETH.2024.110193

Poster sessions–late breaking abstracts

Published in: Journal of Sleep Research, Issue 33, 2024, ISSN 0962-1105
Publisher: Wiley
DOI: 10.1111/JSR.14293

Spatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro

Author(s): Joana Covelo, Alessandra Camassa, Jose Manuel Sanchez-Sanchez, Arnau Manasanch, Leonardo Dalla Porta, Nathalia Cancino-Fuentes, Almudena Barbero-Castillo, Rita M. Robles, Miquel Bosch, Silvia Tapia-Gonzalez, Paula Merino-Serrais, Mar Carreño, Estefania Conde-Blanco, Jordi Rumià Arboix, Pedro Roldán, Javier DeFelipe, Maria V. Sanchez-Vives
Published in: Progress in Neurobiology, Issue 246, 2025, ISSN 0301-0082
Publisher: Elsevier BV
DOI: 10.1016/J.PNEUROBIO.2025.102719

Modelling low-dimensional interacting brain networks reveals organising principle in human cognition

Author(s): Yonatan Sanz Perl, Sebastian Geli, Eider Pérez-Ordoyo, Lou Zonca, Sebastian Idesis, Jakub Vohryzek, Viktor K. Jirsa, Morten L. Kringelbach, Enzo Tagliazucchi, Gustavo Deco
Published in: Network Neuroscience, 2025, ISSN 2472-1751
Publisher: MIT Press
DOI: 10.1162/NETN_A_00434

Frontiers in Neuroinformatics

Author(s): Noelia Martínez-Molina; Yonatan Sanz-Perl; Anira Escrichs; Morten L. Kringelbach; Morten L. Kringelbach; Morten L. Kringelbach; Gustavo Deco; Gustavo Deco
Published in: Frontiers in Neuroinformatics, 2024, ISSN 1662-5196
Publisher: Lausanne: Frontiers Media S.A
DOI: 10.3389/FNINF.2024.1382372

Pre-stimulus neural dynamics predict TMS responses: The role of fractal dimension and oscillatory activity

Author(s): A.L. Bisogno, S. Moaveninejad, M. Corbetta, C. Porcaro
Published in: Computers in Biology and Medicine, Issue 198, 2025, ISSN 0010-4825
Publisher: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2025.111220

Switching Patterns of Cortical–Subcortical Interaction in the Human Brain

Author(s): Alessandro Nazzi, Chiara Favaretto, Antonino Vallesi, Maurizio Corbetta, Michele Allegra
Published in: The Journal of Neuroscience, Issue 45, 2025, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1855-24.2025

Covert consciousness: what’s in a name?

Author(s): Charlène Aubinet, Jan Claassen, Brian L Edlow, David Fischer, Olivia Gosseries, Christof Koch, Daniel Kondziella, Marcello Massimini, Michael J Young
Published in: Brain, 2025, ISSN 0006-8950
Publisher: Oxford University Press (OUP)
DOI: 10.1093/BRAIN/AWAF349

Conscious tactile perception entails distinct neural dynamics within somatosensory areas

Author(s): Davide Albertini, Maria Del Vecchio, Ivana Sartori, Andrea Pigorini, Francesca Talami, Flavia Maria Zauli, Simone Sarasso, Ezequiel Pablo Mikulan, Marcello Massimini, Pietro Avanzini
Published in: Current Biology, Issue 35, 2025, ISSN 0960-9822
Publisher: Elsevier BV
DOI: 10.1016/J.CUB.2025.04.052

Scientific Reports

Author(s): Adrián Ponce-Alvarez; Gustavo Deco
Published in: The Hopf whole-brain model and its linear approximation, 2023, ISSN 2045-2322
Publisher: Springer
DOI: 10.21203/RS.3.RS-3361733/V1

Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness

Author(s): Mindlin, I; Herzog, R; Belloli, L; Manasova, D; Monge-Asensio, M; Vohryzek, J; Escrichs, A; Alnagger, N; Núñez, P; Gosseries, O; Kringelbach, ML; Deco, G; Tagliazucchi, E; Naccache, L; Rohaut, B; Sitt, JD; Sanz Perl, Y
Published in: Communications Biology, 2024, ISSN 2399-3642
Publisher: Springer
DOI: 10.1038/S42003-024-06852-9

Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions

Author(s): Sebastian Idesis, Gustavo Patow, Michele Allegra, Jakub Vohryzek, Yonatan Sanz Perl, Maria V. Sanchez-Vives, Marcello Massimini, Maurizio Corbetta, Gustavo Deco
Published in: Neurobiology of Disease, Issue 200, 2024, ISSN 0969-9961
Publisher: Elsevier BV
DOI: 10.1016/J.NBD.2024.106613

Investigating the Impact of Local Manipulations on Spontaneous and Evoked Brain Complexity Indices: A Large-Scale Computational Model

Author(s): Gianluca Gaglioti, Thierry Ralph Nieus, Marcello Massimini, Simone Sarasso
Published in: Applied Sciences, Issue 14, 2025, ISSN 2076-3417
Publisher: MDPI AG
DOI: 10.3390/APP14020890

A common low dimensional structure of cognitive impairment in stroke and brain tumors

Author(s): Silvia Facchini, Chiara Favaretto, Marco Castellaro, Andrea Zangrossi, Margherita Zannin, Antonio Luigi Bisogno, Valentina Baro, Maria Giulia Anglani, Antonio Vallesi, Claudio Baracchini, Domenico D'Avella, Alessandro Della Puppa, Carlo Semenza, Maurizio Corbetta
Published in: NeuroImage: Clinical, Issue 40, 2025, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/J.NICL.2023.103518

Scientific Reports

Author(s): Idesis, Sebastian; Allegra, Michele; Vohryzek, Jakub; Sanz Perl, Yonatan; Faskowitz, Joshua; Sporns, Olaf; Corbetta, Maurizio; Deco, Gustavo
Published in: A low dimensional embedding of brain dynamics enhances diagnostic accuracy and behavioral prediction in stroke, 2023, ISSN 2045-2322
Publisher: Springer
DOI: 10.1038/S41598-023-42533-Z

Reduction of sleep-like perilesional slow waves and clinical evolution after stroke: A TMS-EEG study

Author(s): S. Sarasso, S. D’Ambrosio, S. Russo, L. Bernardelli, G. Hassan, A. Comanducci, P. De Giampaulis, L.A. Dalla Vecchia, J. Lanzone, M. Massimini
Published in: Clinical Neurophysiology, Issue 175, 2025, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/J.CLINPH.2025.2110746

Detecting cortical reactivity alterations induced by structural disconnection in subcortical stroke

Author(s): Sasha D'Ambrosio, Francesco Certo, Letizia Bernardelli, Lorenzo Pini, Maurizio Corbetta, Leonardo Pantoni, Marcello Massimini, Simone Sarasso
Published in: Clinical Neurophysiology, Issue 156, 2024, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/J.CLINPH.2023.09.007

Whole-brain dynamics across the menstrual cycle: the role of hormonal fluctuations and age in healthy women

Author(s): Daniela S. Avila-Varela; Esmeralda Hidalgo-Lopez; Paulina Clara Dagnino; Irene Acero-Pousa; Elvira del Agua; Gustavo Deco; Belinda Pletzer; Anira Escrichs
Published in: npj Women's Health, 2024, ISSN 2948-1716
Publisher: Springer
DOI: 10.1038/S44294-024-00012-4

Large-scale network topography of stroke predicts functional outcome after mechanical thrombectomy

Author(s): Antonio Luigi Bisogno, Lorenzo Pini, Sofia Raccanello, Giorgia Adamo, Joseph Domenico Gabrieli, Alessandro Salvalaggio, Anna Maria Basile, Claudio Baracchini, Maurizio Corbetta
Published in: Brain Communications, Issue 7, 2025, ISSN 2632-1297
Publisher: Oxford University Press (OUP)
DOI: 10.1093/BRAINCOMMS/FCAF285

Whole-brain modelling: an essential tool for understanding brain dynamics

Author(s): Gustavo Patow; Ignacio Martin; Yonatan Sanz Perl; Morten L. Kringelbach; Gustavo Deco
Published in: Nature Reviews Methods Primers, 2024, ISSN 2662-8449
Publisher: Springer
DOI: 10.1038/S43586-024-00336-0

European Journal of Neuroscience

Author(s): Casarotto, Silvia; Hassan, Gabriel; Rosanova, Mario; Sarasso, Simone; Derchi, Chiara-Camilla; Trimarchi, Pietro Davide; Viganò, Alessandro; Russo, Simone; Fecchio, Matteo; Devalle, Guya; Navarro, Jorge; Massimini, Marcello; Comanducci, Angela
Published in: European Journal of Neuroscience, 2024, ISSN 0953-816X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/EJN.16299

Other (1)

Generative whole-brain dynamics models from healthy subjects predict functional alterations in stroke at the level of individual patients

Author(s): Sebastián Idesis; Michele Allegra; Jakub Vohryzek; Yonatan Sanz Perl; Nicholas V. Metcalf; Joseph C. Griffis; Maurizio Corbetta; Gordon L. Shulman; Gustavo Deco
Published in: Brain Communications, 2024
DOI: 10.1093/BRAINCOMMS/FCAE237