Project description DEENESFRITPL Novel tolerogenic therapies for autoimmune diseases Funded by the Marie Skłodowska-Curie Actions programme, the TOLERATE project will provide training in the development of innovative strategies for autoimmune disease treatment to bring novel therapeutic agents to the market. The objective is to introduce innovative tolerogenic therapies for the treatment of autoimmune diseases using cell therapy, nanotechnology and protein-engineered tolerogenic vaccines to re-establish immune tolerance. The TOLERATE platform will provide eight doctoral candidates with unique interdisciplinary clinical skills together with additional training in ethical, regulatory and legal aspects in the development of therapeutics and diagnostics for autoimmune diseases. Show the project objective Hide the project objective Objective The TOLERATE training network aims at training DC’s to acquire the skills to develop different innovative strategies to treat autoimmune diseases, to identify the most promising strategies or a combination of strategies, to setup clinical trials and to develop a roadmap to bring a novel therapeutic agent to the market. This all will be done in a highly interdisciplinary and intersectoral environment. Interdisciplinarity allows to introduce innovative tolerogenic therapies developed for cancer, Chimer Antigen Receptor (CAR)-T cell therapies, into the world of autoimmune disease and to apply nanotechnology and protein-engineered tolerogenic vaccines to re-establish immune tolerance in autoimmune disease. Both the presence of academia and industry provides a platform for in-depth preclinical studies and a realistic possibility for future commercialization of the novel therapies. Clinicians in the consortium with expertise in setting-up and running clinical trials for novel drugs assure that developed novel therapies in TOLERATE will find their way to the clinic in the future. Developing novel therapies for autoimmune diseases goes close together with a thorough knowledge on the long-term consequences of living with an autoimmune disease. Since many autoimmune diseases are rare diseases, setting up international uniform databases and biobanks is crucial to understand the long-term pathophysiology of the disease and to guarantee optimal use of (novel) therapies. TOLERATE will train 8 DCs who will hence has the expertise and skills to work in and setup interdisciplinary and intersectoral projects. The ground-breaking training programme will provide the DC’s with a unique clinical training. Additional training in ethical, regulatory and legal aspects together with a training in innovation management of therapeutics and diagnostics for autoimmune diseases will prepare the DCs for the European job market. Fields of science medical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesmedical biotechnologycells technologies Keywords Autoimmune disease Tolerogenic vaccine T cell receptor engineered Tregs CAR-T cell therapy Immune-mediated thrombotic thrombocytopenic purpura Clearance Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2021-DN-01-01 - MSCA Doctoral Networks 2021 Call for proposal HORIZON-MSCA-2021-DN-01 See other projects for this call Funding Scheme HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks Coordinator KATHOLIEKE UNIVERSITEIT LEUVEN Net EU contribution € 262 620,00 Address OUDE MARKT 13 3000 Leuven Belgium See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Stichting Sanquin Bloedvoorziening Netherlands Net EU contribution € 274 370,40 Address Plesmanlaan 125 1006 AN Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data SEMMELWEIS EGYETEM Hungary Net EU contribution € 228 348,00 Address ULLOI UTCA 26 1085 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France Net EU contribution € 282 693,60 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data ROYAL COLLEGE OF SURGEONS IN IRELAND Ireland Net EU contribution € 286 488,00 Address ST STEPHEN'S GREEN 123 2 Dublin See on map Region Ireland Northern and Western Border Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV Germany Net EU contribution € 260 539,20 Address BAUTZNER LANDSTRASSE 400 01328 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data ANICELLS Belgium Net EU contribution € 262 620,00 Address GALILEILAAN 21 2845 Niel See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data AHEAD THERAPEUTICS SL Spain Net EU contribution € 251 971,20 Address EDIFICI EUREKA PARC RECERCA UAB CAMPUS UAB S/N 08193 Cerdanyola Del Valles See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partners (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Biokit Research & Development S.L.U. Spain Net EU contribution € 0,00 Address Av. Can Montcau, 7 08186 Llica d Amunt See on map Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data EUROPEAN HEMATOLOGY ASSOCIATION Netherlands Net EU contribution € 0,00 Address KONINGINNEGRACHT 12B/13 2514 AA Den Haag See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data UNIVERSITAT AUTONOMA DE BARCELONA Spain Net EU contribution € 0,00 Address EDIF A CAMPUS DE LA UAB BELLATERRA CERDANYOLA V 08193 Cerdanyola Del Valles See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data STICHTING AMSTERDAM UMC Netherlands Net EU contribution € 0,00 Address DE BOELELAAN 1117 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data UNIVERSITEIT VAN AMSTERDAM Netherlands Net EU contribution € 0,00 Address SPUI 21 1012WX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data INNOVATION ACTA SRL Italy Net EU contribution € 0,00 Address VIA DELLE PROVINCE 1 53100 Siena See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data UNIVERSITEIT ANTWERPEN Belgium Net EU contribution € 0,00 Address PRINSSTRAAT 13 2000 Antwerpen See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data SORBONNE UNIVERSITE France Net EU contribution € 0,00 Address 21 RUE DE L'ECOLE DE MEDECINE 75006 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data TECHNISCHE UNIVERSITAET DRESDEN Germany Net EU contribution € 0,00 Address HELMHOLTZSTRASSE 10 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Immudex Aps Denmark Net EU contribution € 0,00 Address See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
