Description du projet
Application de la relaxométrie à cyclage de champ en biomédecine et en science des matériaux
La relaxométrie à cycle de champ constitue un outil polyvalent permettant de surveiller la structure et la dynamique sur une large échelle de temps, de la picoseconde à la milliseconde, fournissant des informations sur les propriétés des systèmes biologiques et des matériaux avancés. Financé par le programme Actions Marie Skłodowska-Curie, le réseau de formation du projet FC-RELAX implique certains des principaux experts européens dans ce domaine. Il vise à développer les connaissances théoriques des processus de relaxation dépendant du champ et à étudier le potentiel de la relaxométrie à cyclage de champ pour les applications biomédicales et la caractérisation des matériaux avancés. Ses objectifs incluent l’amélioration des agents de contraste de l’imagerie par résonance magnétique et des nanosystèmes paramagnétiques pour la théranostique, le développement de matériaux et leur application pour le diagnostic du cancer.
Objectif
Field-cycling relaxometry experienced a tremendous boost during the last decade. It represents an ease and versatile tool to monitor structure and dynamics in a wide range of time scales, from picoseconds to milliseconds, providing information of great importance for understanding the properties of biological systems and improving materials and drugs. Despite the numerous, emerging possibilities of applications, theoretical approaches for the analysis of the relaxometry data are often controversial and, for some systems, accurate models have not been identified. The FC-RELAX project aims at developing the theoretical knowledge of the field dependent relaxation processes taking advantage of the joint effort of some of the main European actors in the field, and at exploiting all potentialities of field-cycling relaxometry for different biomedical applications and for the characterization of advanced materials. The objectives are the improvement of efficacy and safety of MRI contrast agents and paramagnetic nanosystems for theranostics, the exploitation of relaxometry for cancer diagnosis and for the development of partially crystalline materials, and of ionic liquids for their use as electrolytes in energy storage devices. The program is based on high-level multidisciplinary and multisectoral training, and on a consortium of tight and complementary experimental scientists and theoreticians. FC-RELAX comprises 10 academic partners and 3 companies from 8 European countries, and will train 10 researchers who will benefit by extensive interactions between academic and industrial partners, endowed with state-of-the art scientific and technical expertise and infrastructures. The industrial partners include the only company in the world producing field-cycling relaxometers, a European company leader in the research and production of MRI contrast agents, and a scientific oriented technology company on the world market of magnetic resonance instrumentation.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinateur
50121 Florence
Italie