Cellular Homeostasis ANd AGing in Connective TissuE Disorders

Información del proyecto

CHANGE

Identificador del acuerdo de subvención: 101072766

DOI

10.3030/101072766

Proyecto cerrado

Fecha de la firma de la CE 11 Julio 2022

Fecha de inicio 1 Septiembre 2022

Fecha de finalización 31 Agosto 2026

Financiado con arreglo a

Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 2 692 173,60

Coordinado por

UNIVERSITA DEGLI STUDI DI PAVIA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Annual newsletters

Annual newsletters detailing the activities and achievements of the consortium will be published on the consortium website, sent via email to all stakeholders and promoted via the consortium's social media channels.

Educational materials

Delivery of remote (online) learning, distance education, and the use of educational technologies to enhance students learning experiences while reducing the overall carbon print of theconsortium. Participants will share online training materials (e.g. educational videos, lecture notes and slides). Webinars and massive open online courses(MOOCs) will also be organised on subjects relevant to the participants expertise, within the context of the CHANGE research activities.

Project’s website

Project website will feature information and educational material co-edited by the ESRs and relating to the projects research areas as well as regular news and soundbites about the projects achievements and discoveries.

Publicaciones

CONTRIBUTION OF NOREPINEPHRINE AND THE AGEING AUTONOMIC NERVOUS SYSTEM TO SPINE DEGENERATION

Autores: Matteo Signor, Carsten Graumann, Gundula Rösch, Panagiotis Diaremes, Giulio Gatto, Frank Zaucke, Zsuzsa Jenei-Lanzl
Publicado en: 2024
Editor: N/A

Morphological and biochemical analysis of musculoskeletal pathology in a murine model of diastrophic dysplasia

Autores: Asifa Khan, Alessandra Leone, Matteo Signor, Giulio Gatto, Michal Tamáš, Zsuzsa Jenei-Lanzl, Nitin George Eapen, Paolo Bonaldo, Marcus Krüger, Frank Zaucke, Antonella Forlino, Antonio Rossi
Publicado en: ARI Orthopaedics 2026 - Cartilage & Disc, Congress Center, Davos, Switzerland, 2026
Editor: RI Orthopaedics 2026 - Cartilage & Disc, Congress Center, Davos, Switzerland

Morphological and biochemical analysis of musculoskeletal pathology in a murine model of diastrophic dysplasia

Autores: Asifa Khan, Alessandra Leone, Matteo Signor, Giulio Gatto, Michal Tamáš, Zsuzsa Jenei-Lanzl, Nitin George Eapen, Paolo Bonaldo, Marcus Krüger, Frank Zaucke, Antonella Forlino, Antonio Rossi
Publicado en: Annual Meeting of the German Society for Matrix Biology, Heidelberg, Germany, 2026
Editor: Annual Meeting of the German Society for Matrix Biology, Heidelberg, Germany

CHANGE: Cellular Homeostasis ANd AGing in Connective TissuE Disorders

Autores: Giulio Gatto, Matteo Signor, Wendy Perez Franco, Asifa Khan, Zsuzsa Jenei-Lanzl, Frank Zaucke, Antonio Rossi, Antonella Forlino
Publicado en: 2023
Editor: none

Investigating the role of misfolded collagen I in skeletal and cardiorespiratory aging

Autores: Pérez-Franco, W., Besio R., Filibian M., Gioia R., Grillari G., Ogrodnik M., Schädl B., Jagersberger T., Löscher A., Forlino, A.
Publicado en: 2026
Editor: matrixbiologie

Unrevealing the multi-organ consequence of osteogenesis imperfecta in aging

Autores: Wendy Perez Franco,Roberta Besio, Antonella Forlino
Publicado en: 2024
Editor: MBE24

Insights in the musculoskeletal phenotype of an animal model of diastrophic dysplasia

Autores: Asifa Khan, Alessandra Leone, Frank Zaucke, Zsuzsa Jenei-Lanzl, Michal Tamáš, Paolo Bonaldo, Chantal Fayad, Matteo Signor, Giulio Gatto, Laurence Legai-Mallet
Publicado en: A Castellani meeting of PhD students in Biochemical Science, Brallo di Pregola, Italy, 2025

Pro143Leu KIF22 mutation affect cartilage structure in the SEMDJL2 mice

Autores: Roufaida Bouchenafa; Elias Ben-Tiba; Francesca de Sousa Brito; Katarzyna Anna Pirog
Publicado en: International Journal of Experimental Pathology, 2024
Editor: Wiley

Insights in the adult skeletal phenotype of an animal model of diastrophic dysplasia

Autores: Asifa Khan, Alessandra Leone, Chiara Gramegna Tota, Chiara Paganini, Ottavia Ferraro, Simona Villani, Antonella Forlino, Eric Hay, Martine Cohen-Solal, Antonio Rossi
Publicado en: 2024
Editor: Matrix Biology Europe 2024

p.Pro148Leu KIF22 mutation affects bone structure and properties in a knock-in mouse model of SEMDJL2

Autores: Roufaida Bouchenafa, Francesca de Sousa Brito, Roberta Gioia, Antonella Forlino, Katarzyna Anna Pirog
Publicado en: Journal of Histochemistry & Cytochemistry, 2026
Editor: Sage
DOI: 10.1369/00221554261448876

Pro143Leu KIF22 mutation affect cartilage structure in the SEMDJL2 mice.

Autores: Bouchenafa R, Ben-Tiba E, Johnson de Sousa Brito FM, Pirog KA.
Publicado en: Int J Exp Path, 2024
Editor: Wiley
DOI: 10.1111/IEP.12512

Structural and biochemical signatures of musculoskeletal tissues in a murine model of diastrophic dysplasia

Autores: Asifa Khan, Alessandra Leone, Frank Zaucke, Zsuzsa Jenei-Lanzl, Michal Tamáš, Paolo Bonaldo, Matteo Signor, Giulio Gatto, Antonella Forlino, Antonio Rossi
Publicado en: 7th MuSkITYR Symposium, Dresden, Germany, 2025
Editor: 7th MuSkITYR Symposium, Dresden, Germany

668 - TOWARDS AN EX VIVO CARTILAGE DAMAGE MODEL TO STUDY CARTILAGE DAMAGE PROGRESSION AND REPAIR

Autores: João M. Pinheiro, Keita Ito, Gerjo J. van Osch, Linda Kock
Publicado en: Edición Volume 33, Supplement, Page S461, 2025, ISSN 1053-4584
Editor: Osteoarthritis and Cartilage
DOI: 10.1016/J.JOCA.2025.02.676

Involvement of kinesins in skeletal dysplasia: a review

Autores: Roufaida Bouchenafa; Francesca Manuela Johnson de Sousa Brito; Katarzyna Anna Piróg
Publicado en: Crossref, 2024
Editor: APS (Americal Physiological Society)
DOI: 10.1152/AJPCELL.00613.2023

Spinal Kyphosis and Intervertebral Disc Degeneration in a mouse model of Diastrophic Dysplasia

Autores: Asifa Khan, Alessandra Leone, Chiara Paganini, Matteo Signor, Giulio Gatto, Zsuzsa Jenei-Lanzl, Nitin George Eapen, Marcus Krüger, Frank Zaucke, Antonella Forlino, Antonio Rossi
Publicado en: 2026

CONTRIBUTION OF NOREPINEPHRINE AND THE AGEING AUTONOMIC NERVOUS SYSTEM TO SPINE DEGENERATION

Autores: Matteo Signor, Carsten Graumann, Gundula Rösch, Panagiotis Diaremes, Giulio Gatto, Frank Zaucke, Zsuzsa Jenei-Lanzl
Publicado en: 2024
Editor: none

Unrevealing the multi-organ consequence of osteogenesis imperfecta in aging

Autores: Wendy Perez Franco,Roberta Besio, Antonella Forlino
Publicado en: 2025
Editor: UNIPV

Morphological and biochemical changes in the musculoskeletal phenotype of an animal model of diastrophic dysplasia

Autores: Asifa Khan, Alessandra Leone, Frank Zaucke, Zsuzsa Jenei-Lanzl, Michal Tamáš, Paolo Bonaldo, Matteo Signor, Giulio Gatto, Antonella Forlino, Antonio Rossi
Publicado en: Italian Society for the Study of Connective Tissue / Matrix Biology Italy (SISC/MBIta) congress, Messeina, Italy, 2025

Role of Collection Media on the Biological Activity of Extracellular Vesicles From hTERT‐Immortalised Mesenchymal Stromal Cells

Autores: Alessia Brancolini, Madhusudhan Reddy Bobbili, Matthias Wieser, Johanna Gamauf, Marieke Theodora Roefs, Elsa Arcalis, Silke Aldrian, Sebastien Couillard‐Despres, Lara Bieler, Johannes Grillari, Regina Grillari‐Voglauer
Publicado en: Journal of Extracellular Vesicles, Edición 15, 2026, ISSN 2001-3078
Editor: Wiley
DOI: 10.1002/JEV2.70298

Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles

Autores: Alessia Brancolini, Madhusudhan Reddy Bobbili, Marianne Pultar, Zahra Mazidi, Matthias Wieser, Johanna Gamauf, Marieke Theodora Roefs, Giulia Corso, Harini Nivarthi, Maria Belen Arteaga Paredes, Dieter Bettelheim, Elsa Arcalis, Sivun Dmitry, Jaroslaw Jacak, Iris Gerner, Andrea Bileck, Christoper Gerner, Matthias Hackl, Johannes Grillari, Regina Grillari-Voglauer
Publicado en: Journal of Biotechnology, Edición 414, 2026, ISSN 0168-1656
Editor: Elsevier BV
DOI: 10.1016/J.JBIOTEC.2026.03.010

Exploring the brain in osteogenesis imperfecta: insights from the motor cortex and striatum of the Brtl+/− murine model

Autores: Emma Lugli, Roberta Besio, Margherita Cavallo, Ludovica Gaiaschi, Wendy Pérez Franco, Gloria Milanesi, Antonella Forlino, Maria Grazia Bottone, Fabrizio De Luca
Publicado en: Acta Neuropathologica Communications, 2026, ISSN 2051-5960
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S40478-026-02393-W

Multi-parametric profiling of plasma-derived extracellular vesicles reveals a disease-associated molecular signature supporting a liquid biopsy approach in myelofibrosis

Autores: Ghazal Narimanfar, Husam B. R. Alabed, Alessia Brancolini, Roberto Maria Pellegrino, Martina Barone, Claudia Venturi, Hillary Catellani, Giovanni Torsello, Luca Pestarino, Andrea Cavalli, Alessandra D’Addio, Alessia Tieghi, Regina Grillari-Voglauer, Francesca Palandri, Lucia Catani
Publicado en: Molecular Medicine, Edición 32, 2026, ISSN 1528-3658
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S10020-026-01477-6

A zebrafish model of Bethlem myopathy reveals CaV1.1 as the missing link between collagen type VI deficiency and muscle dysfunction

Autores: Romane Idoux, Chloé Exbrayat-Heritier, Adrien Ducret, Shivashakthi Shivaraman, Marilyne Malbouyres, Francisco Jaque-Fernandez, Christine Berthier, Frédéric Sohm, Vincent Jacquemond, Sandrine Bretaud, Florence Ruggiero, Bruno Allard
Publicado en: 2026
Editor: openRxiv
DOI: 10.1101/2025.06.02.657388

Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease

Autores: Silvia Cotti, Wendy Pérez Franco, Antonella Forlino
Publicado en: Clinical Science, Edición 139, 2025, ISSN 0143-5221
Editor: Portland Press Ltd.
DOI: 10.1042/CS20255642

Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage

Autores: Sarah McNeilly, Cameron R. Thomson, Laura Gonzalez-Trueba, Yuan Yan Sin, Alessandra Granata, Graham Hamilton, Michelle Lee, Erin Boland, John D. McClure, Cristina Lumbreras-Perales, Alisha Aman, Apoorva A. Kumar, Marco Cantini, Caglar Gök, Delyth Graham, Yasuko Tomono, Christopher D. Anderson, Yinhui Lu, Colin Smith, Hugh S. Markus, Marc Abramowicz, Catheline Vilain, Rustam Al-Shahi Salman, Manuel Salmeron-Sanchez, Atticus H. Hainsworth, William Fuller, Karl E. Kadler, Neil J. Bulleid, Tom Van Agtmael
Publicado en: eBioMedicine, Edición 107, 2024, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105315

Rapid extracellular vesicle surface decoration with targeting moieties based on a fluorescein binding single chain variable fragment snorkel

Autores: Marieke Theodora Roefs, Johanna Gamauf, Barbara Kroenigsberger, Alessia Brancolini, Michael W. Traxlmayr, Elsa Arcalis, Jaroslaw Jacak, Marcelle van Mechelen, Jean-Paul Prieels, Regina Grillari-Voglauer, Johannes Grillari, Madhusudhan Reddy Bobbili
Publicado en: Journal of Controlled Release, Edición 390, 2026, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/J.JCONREL.2025.114558

TYRA-300, an FGFR3-selective inhibitor, promotes bone growth in two FGFR3-driven models of chondrodysplasia

Autores: Jacqueline H. Starrett, Clara Lemoine, Matthias Guillo, Chantal Fayad, Nabil Kaci, Melissa Neal, Emily A. Pettitt, Melissandre Pache, Qing Ye, My Chouinard, Eric L. Allen, Geneviève Baujat, Robert L. Hudkins, Michael B. Bober, Todd Harris, Ronald V. Swanson, Laurence Legeai-Mallet
Publicado en: JCI Insight, Edición 10, 2025, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI.INSIGHT.189307

Osteogenesis Imperfecta: A Look into the Cerebellum of the Brtl Murine Model

Autores: Fabrizio De Luca, Roberta Besio, Emma Lugli, Enrico Pelloni, Claudio Casali, Wendy Pérez Franco, Ludovica Gaiaschi, Federica Gola, Margherita Cavallo, Gloria Milanesi, Antonella Forlino, Maria Grazia Bottone
Publicado en: Molecular Neurobiology, Edición 62, 2025, ISSN 0893-7648
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S12035-025-05205-9

Extracellular Matrix–Driven Dysregulation of Skeletal Muscle Homeostasis in Collagen VI Deficiency Across Ageing

Autores: Michal Tamáš
Publicado en: 2026
Editor: PhD thesis, PhD Course in Biosciences, Curriculum Cell Biology and Physiology, Series XXXVIII

Dissecting the multi-organ consequences to misfolded collagen I in aging

Autores: Pérez-Franco, W., Besio R., Forlino, A.
Publicado en: 2026
Editor: ThesisDC1

MECHANICALLY INDUCED DEGENERATION IN OSTEOCHONDRAL EXPLANTS: AN EX VIVO PLATFORM FOR STUDYING OSTEOARTHRITIS

Autores: João Pinheiro
Publicado en: 2026
Editor: University of Pavia Repository

Skeletal Dysplasias Caused by Defects in Glycosaminoglycan Sulfation.

Autores: Gramegna Tota, C., Leone, A., Paganini, C., Khan, A., Rossi, A., Superti-Furga, A.
Publicado en: Springer, 2024
Editor: The Extracellular Matrix in Genetic Skeletal Disorders

FGF Signaling: A Key Pathway During Skeletal Development

Autores: Chantal Fayad, Laurence Legeai-Mallet
Publicado en: Springer Cham, 2024
Editor: The Extracellular Matrix in Genetic Skeletal Disorders
DOI: 10.1007/978-3-031-70835-0_8

FGF Signaling: A Key Pathway During Skeletal Development

Autores: Chantal Fayad, Laurence Legeai-Mallet
Publicado en: Springer Nature, 2024
Editor: Springer

Osteogenesis imperfecta and related diseases – collagen I alterations in skeletal and extraskeletal tissues

Autores: Giulio Gatto, WendyPérez Franco, Heike-Katharina Hoyer-Kuhn, Oliver Semle, Antonella Forlino, Roberta Besio
Editor: Springer Nature

Skeletal Dysplasias Caused by Defects in Glycosaminoglycan Sulfation

Autores: Chiara Gramegna Tota, Alessandra Leone, Chiara Paganini, Asifa Khan, Antonio Rossi, Andrea Superti-Furga
Publicado en: Biology of Extracellular Matrix, The Extracellular Matrix in Genetic Skeletal Disorders, 2024
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-70835-0_6

Mitochondrial dysfunction plays a key role in premature musculoskeletal aging in hypochondroplasia mouse model

Autores: Chantal Fayad, Michal Tamáš, Giulio Gatto, Dimitrije Milunov, Soham Saha, Paolo Bonaldo, Frank Zaucke and Laurence Legeai-Mallet, PhD
Publicado en: 2026
Editor: JBMR

Role of Fgf Signaling in Hypochondroplasia Mouse Model During Aging

Autores: Chantal Fayad, Camille Viaut, Michal Tamáš, Paolo Bonaldo and Laurence Legeai-Mallet, PhD
Publicado en: 2025
Editor: JBMR

Defective Memory is restored and Epileptic seizures are rescued in a Mouse Model of Hypochondroplasia by the FGFR Inhibitor Infigratinib

Autores: Chantal Fayad, Lea Loisay, Charline Vilpreux, Stéphanie Moriceau, Franck Oury, Genevieve Baujat, Nathalie Boddaert, Laurence Legeai-Mallet
Publicado en: 2026
Editor: JBMR

The Extracellular Matrix in Genetic Skeletal Disorders

Publicado en: Biology of Extracellular Matrix, 2024
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-70835-0

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