Cellular Homeostasis ANd AGing in Connective TissuE Disorders

Informacje na temat projektu

CHANGE

Identyfikator umowy o grant: 101072766

DOI

10.3030/101072766

Projekt został zamknięty

Data podpisania przez KE 11 Lipca 2022

Data rozpoczęcia 1 Września 2022

Data zakończenia 31 Sierpnia 2026

Finansowanie w ramach

Marie Skłodowska-Curie Actions (MSCA)

Koszt całkowity

Brak danych

Wkład UE

€ 2 692 173,60

Koordynowany przez

UNIVERSITA DEGLI STUDI DI PAVIA
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Annual newsletters

Annual newsletters detailing the activities and achievements of the consortium will be published on the consortium website, sent via email to all stakeholders and promoted via the consortium's social media channels.

Educational materials

Delivery of remote (online) learning, distance education, and the use of educational technologies to enhance students learning experiences while reducing the overall carbon print of theconsortium. Participants will share online training materials (e.g. educational videos, lecture notes and slides). Webinars and massive open online courses(MOOCs) will also be organised on subjects relevant to the participants expertise, within the context of the CHANGE research activities.

Project’s website

Project website will feature information and educational material co-edited by the ESRs and relating to the projects research areas as well as regular news and soundbites about the projects achievements and discoveries.

Publikacje

CONTRIBUTION OF NOREPINEPHRINE AND THE AGEING AUTONOMIC NERVOUS SYSTEM TO SPINE DEGENERATION

Autorzy: Matteo Signor, Carsten Graumann, Gundula Rösch, Panagiotis Diaremes, Giulio Gatto, Frank Zaucke, Zsuzsa Jenei-Lanzl
Opublikowane w: 2024
Wydawca: N/A

Morphological and biochemical analysis of musculoskeletal pathology in a murine model of diastrophic dysplasia

Autorzy: Asifa Khan, Alessandra Leone, Matteo Signor, Giulio Gatto, Michal Tamáš, Zsuzsa Jenei-Lanzl, Nitin George Eapen, Paolo Bonaldo, Marcus Krüger, Frank Zaucke, Antonella Forlino, Antonio Rossi
Opublikowane w: ARI Orthopaedics 2026 - Cartilage & Disc, Congress Center, Davos, Switzerland, 2026
Wydawca: RI Orthopaedics 2026 - Cartilage & Disc, Congress Center, Davos, Switzerland

Morphological and biochemical analysis of musculoskeletal pathology in a murine model of diastrophic dysplasia

Autorzy: Asifa Khan, Alessandra Leone, Matteo Signor, Giulio Gatto, Michal Tamáš, Zsuzsa Jenei-Lanzl, Nitin George Eapen, Paolo Bonaldo, Marcus Krüger, Frank Zaucke, Antonella Forlino, Antonio Rossi
Opublikowane w: Annual Meeting of the German Society for Matrix Biology, Heidelberg, Germany, 2026
Wydawca: Annual Meeting of the German Society for Matrix Biology, Heidelberg, Germany

CHANGE: Cellular Homeostasis ANd AGing in Connective TissuE Disorders

Autorzy: Giulio Gatto, Matteo Signor, Wendy Perez Franco, Asifa Khan, Zsuzsa Jenei-Lanzl, Frank Zaucke, Antonio Rossi, Antonella Forlino
Opublikowane w: 2023
Wydawca: none

Investigating the role of misfolded collagen I in skeletal and cardiorespiratory aging

Autorzy: Pérez-Franco, W., Besio R., Filibian M., Gioia R., Grillari G., Ogrodnik M., Schädl B., Jagersberger T., Löscher A., Forlino, A.
Opublikowane w: 2026
Wydawca: matrixbiologie

Unrevealing the multi-organ consequence of osteogenesis imperfecta in aging

Autorzy: Wendy Perez Franco,Roberta Besio, Antonella Forlino
Opublikowane w: 2024
Wydawca: MBE24

Insights in the musculoskeletal phenotype of an animal model of diastrophic dysplasia

Autorzy: Asifa Khan, Alessandra Leone, Frank Zaucke, Zsuzsa Jenei-Lanzl, Michal Tamáš, Paolo Bonaldo, Chantal Fayad, Matteo Signor, Giulio Gatto, Laurence Legai-Mallet
Opublikowane w: A Castellani meeting of PhD students in Biochemical Science, Brallo di Pregola, Italy, 2025

Pro143Leu KIF22 mutation affect cartilage structure in the SEMDJL2 mice

Autorzy: Roufaida Bouchenafa; Elias Ben-Tiba; Francesca de Sousa Brito; Katarzyna Anna Pirog
Opublikowane w: International Journal of Experimental Pathology, 2024
Wydawca: Wiley

Insights in the adult skeletal phenotype of an animal model of diastrophic dysplasia

Autorzy: Asifa Khan, Alessandra Leone, Chiara Gramegna Tota, Chiara Paganini, Ottavia Ferraro, Simona Villani, Antonella Forlino, Eric Hay, Martine Cohen-Solal, Antonio Rossi
Opublikowane w: 2024
Wydawca: Matrix Biology Europe 2024

p.Pro148Leu KIF22 mutation affects bone structure and properties in a knock-in mouse model of SEMDJL2

Autorzy: Roufaida Bouchenafa, Francesca de Sousa Brito, Roberta Gioia, Antonella Forlino, Katarzyna Anna Pirog
Opublikowane w: Journal of Histochemistry & Cytochemistry, 2026
Wydawca: Sage
DOI: 10.1369/00221554261448876

Pro143Leu KIF22 mutation affect cartilage structure in the SEMDJL2 mice.

Autorzy: Bouchenafa R, Ben-Tiba E, Johnson de Sousa Brito FM, Pirog KA.
Opublikowane w: Int J Exp Path, 2024
Wydawca: Wiley
DOI: 10.1111/IEP.12512

Structural and biochemical signatures of musculoskeletal tissues in a murine model of diastrophic dysplasia

Autorzy: Asifa Khan, Alessandra Leone, Frank Zaucke, Zsuzsa Jenei-Lanzl, Michal Tamáš, Paolo Bonaldo, Matteo Signor, Giulio Gatto, Antonella Forlino, Antonio Rossi
Opublikowane w: 7th MuSkITYR Symposium, Dresden, Germany, 2025
Wydawca: 7th MuSkITYR Symposium, Dresden, Germany

668 - TOWARDS AN EX VIVO CARTILAGE DAMAGE MODEL TO STUDY CARTILAGE DAMAGE PROGRESSION AND REPAIR

Autorzy: João M. Pinheiro, Keita Ito, Gerjo J. van Osch, Linda Kock
Opublikowane w: Numer Volume 33, Supplement, Page S461, 2025, ISSN 1053-4584
Wydawca: Osteoarthritis and Cartilage
DOI: 10.1016/J.JOCA.2025.02.676

Involvement of kinesins in skeletal dysplasia: a review

Autorzy: Roufaida Bouchenafa; Francesca Manuela Johnson de Sousa Brito; Katarzyna Anna Piróg
Opublikowane w: Crossref, 2024
Wydawca: APS (Americal Physiological Society)
DOI: 10.1152/AJPCELL.00613.2023

Spinal Kyphosis and Intervertebral Disc Degeneration in a mouse model of Diastrophic Dysplasia

Autorzy: Asifa Khan, Alessandra Leone, Chiara Paganini, Matteo Signor, Giulio Gatto, Zsuzsa Jenei-Lanzl, Nitin George Eapen, Marcus Krüger, Frank Zaucke, Antonella Forlino, Antonio Rossi
Opublikowane w: 2026

CONTRIBUTION OF NOREPINEPHRINE AND THE AGEING AUTONOMIC NERVOUS SYSTEM TO SPINE DEGENERATION

Autorzy: Matteo Signor, Carsten Graumann, Gundula Rösch, Panagiotis Diaremes, Giulio Gatto, Frank Zaucke, Zsuzsa Jenei-Lanzl
Opublikowane w: 2024
Wydawca: none

Unrevealing the multi-organ consequence of osteogenesis imperfecta in aging

Autorzy: Wendy Perez Franco,Roberta Besio, Antonella Forlino
Opublikowane w: 2025
Wydawca: UNIPV

Morphological and biochemical changes in the musculoskeletal phenotype of an animal model of diastrophic dysplasia

Autorzy: Asifa Khan, Alessandra Leone, Frank Zaucke, Zsuzsa Jenei-Lanzl, Michal Tamáš, Paolo Bonaldo, Matteo Signor, Giulio Gatto, Antonella Forlino, Antonio Rossi
Opublikowane w: Italian Society for the Study of Connective Tissue / Matrix Biology Italy (SISC/MBIta) congress, Messeina, Italy, 2025

Role of Collection Media on the Biological Activity of Extracellular Vesicles From hTERT‐Immortalised Mesenchymal Stromal Cells

Autorzy: Alessia Brancolini, Madhusudhan Reddy Bobbili, Matthias Wieser, Johanna Gamauf, Marieke Theodora Roefs, Elsa Arcalis, Silke Aldrian, Sebastien Couillard‐Despres, Lara Bieler, Johannes Grillari, Regina Grillari‐Voglauer
Opublikowane w: Journal of Extracellular Vesicles, Numer 15, 2026, ISSN 2001-3078
Wydawca: Wiley
DOI: 10.1002/JEV2.70298

Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles

Autorzy: Alessia Brancolini, Madhusudhan Reddy Bobbili, Marianne Pultar, Zahra Mazidi, Matthias Wieser, Johanna Gamauf, Marieke Theodora Roefs, Giulia Corso, Harini Nivarthi, Maria Belen Arteaga Paredes, Dieter Bettelheim, Elsa Arcalis, Sivun Dmitry, Jaroslaw Jacak, Iris Gerner, Andrea Bileck, Christoper Gerner, Matthias Hackl, Johannes Grillari, Regina Grillari-Voglauer
Opublikowane w: Journal of Biotechnology, Numer 414, 2026, ISSN 0168-1656
Wydawca: Elsevier BV
DOI: 10.1016/J.JBIOTEC.2026.03.010

Exploring the brain in osteogenesis imperfecta: insights from the motor cortex and striatum of the Brtl+/− murine model

Autorzy: Emma Lugli, Roberta Besio, Margherita Cavallo, Ludovica Gaiaschi, Wendy Pérez Franco, Gloria Milanesi, Antonella Forlino, Maria Grazia Bottone, Fabrizio De Luca
Opublikowane w: Acta Neuropathologica Communications, 2026, ISSN 2051-5960
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S40478-026-02393-W

Multi-parametric profiling of plasma-derived extracellular vesicles reveals a disease-associated molecular signature supporting a liquid biopsy approach in myelofibrosis

Autorzy: Ghazal Narimanfar, Husam B. R. Alabed, Alessia Brancolini, Roberto Maria Pellegrino, Martina Barone, Claudia Venturi, Hillary Catellani, Giovanni Torsello, Luca Pestarino, Andrea Cavalli, Alessandra D’Addio, Alessia Tieghi, Regina Grillari-Voglauer, Francesca Palandri, Lucia Catani
Opublikowane w: Molecular Medicine, Numer 32, 2026, ISSN 1528-3658
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S10020-026-01477-6

A zebrafish model of Bethlem myopathy reveals CaV1.1 as the missing link between collagen type VI deficiency and muscle dysfunction

Autorzy: Romane Idoux, Chloé Exbrayat-Heritier, Adrien Ducret, Shivashakthi Shivaraman, Marilyne Malbouyres, Francisco Jaque-Fernandez, Christine Berthier, Frédéric Sohm, Vincent Jacquemond, Sandrine Bretaud, Florence Ruggiero, Bruno Allard
Opublikowane w: 2026
Wydawca: openRxiv
DOI: 10.1101/2025.06.02.657388

Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease

Autorzy: Silvia Cotti, Wendy Pérez Franco, Antonella Forlino
Opublikowane w: Clinical Science, Numer 139, 2025, ISSN 0143-5221
Wydawca: Portland Press Ltd.
DOI: 10.1042/CS20255642

Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage

Autorzy: Sarah McNeilly, Cameron R. Thomson, Laura Gonzalez-Trueba, Yuan Yan Sin, Alessandra Granata, Graham Hamilton, Michelle Lee, Erin Boland, John D. McClure, Cristina Lumbreras-Perales, Alisha Aman, Apoorva A. Kumar, Marco Cantini, Caglar Gök, Delyth Graham, Yasuko Tomono, Christopher D. Anderson, Yinhui Lu, Colin Smith, Hugh S. Markus, Marc Abramowicz, Catheline Vilain, Rustam Al-Shahi Salman, Manuel Salmeron-Sanchez, Atticus H. Hainsworth, William Fuller, Karl E. Kadler, Neil J. Bulleid, Tom Van Agtmael
Opublikowane w: eBioMedicine, Numer 107, 2024, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105315

Rapid extracellular vesicle surface decoration with targeting moieties based on a fluorescein binding single chain variable fragment snorkel

Autorzy: Marieke Theodora Roefs, Johanna Gamauf, Barbara Kroenigsberger, Alessia Brancolini, Michael W. Traxlmayr, Elsa Arcalis, Jaroslaw Jacak, Marcelle van Mechelen, Jean-Paul Prieels, Regina Grillari-Voglauer, Johannes Grillari, Madhusudhan Reddy Bobbili
Opublikowane w: Journal of Controlled Release, Numer 390, 2026, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/J.JCONREL.2025.114558

TYRA-300, an FGFR3-selective inhibitor, promotes bone growth in two FGFR3-driven models of chondrodysplasia

Autorzy: Jacqueline H. Starrett, Clara Lemoine, Matthias Guillo, Chantal Fayad, Nabil Kaci, Melissa Neal, Emily A. Pettitt, Melissandre Pache, Qing Ye, My Chouinard, Eric L. Allen, Geneviève Baujat, Robert L. Hudkins, Michael B. Bober, Todd Harris, Ronald V. Swanson, Laurence Legeai-Mallet
Opublikowane w: JCI Insight, Numer 10, 2025, ISSN 2379-3708
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/JCI.INSIGHT.189307

Osteogenesis Imperfecta: A Look into the Cerebellum of the Brtl Murine Model

Autorzy: Fabrizio De Luca, Roberta Besio, Emma Lugli, Enrico Pelloni, Claudio Casali, Wendy Pérez Franco, Ludovica Gaiaschi, Federica Gola, Margherita Cavallo, Gloria Milanesi, Antonella Forlino, Maria Grazia Bottone
Opublikowane w: Molecular Neurobiology, Numer 62, 2025, ISSN 0893-7648
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/S12035-025-05205-9

Extracellular Matrix–Driven Dysregulation of Skeletal Muscle Homeostasis in Collagen VI Deficiency Across Ageing

Autorzy: Michal Tamáš
Opublikowane w: 2026
Wydawca: PhD thesis, PhD Course in Biosciences, Curriculum Cell Biology and Physiology, Series XXXVIII

Dissecting the multi-organ consequences to misfolded collagen I in aging

Autorzy: Pérez-Franco, W., Besio R., Forlino, A.
Opublikowane w: 2026
Wydawca: ThesisDC1

MECHANICALLY INDUCED DEGENERATION IN OSTEOCHONDRAL EXPLANTS: AN EX VIVO PLATFORM FOR STUDYING OSTEOARTHRITIS

Autorzy: João Pinheiro
Opublikowane w: 2026
Wydawca: University of Pavia Repository

Skeletal Dysplasias Caused by Defects in Glycosaminoglycan Sulfation.

Autorzy: Gramegna Tota, C., Leone, A., Paganini, C., Khan, A., Rossi, A., Superti-Furga, A.
Opublikowane w: Springer, 2024
Wydawca: The Extracellular Matrix in Genetic Skeletal Disorders

FGF Signaling: A Key Pathway During Skeletal Development

Autorzy: Chantal Fayad, Laurence Legeai-Mallet
Opublikowane w: Springer Cham, 2024
Wydawca: The Extracellular Matrix in Genetic Skeletal Disorders
DOI: 10.1007/978-3-031-70835-0_8

FGF Signaling: A Key Pathway During Skeletal Development

Autorzy: Chantal Fayad, Laurence Legeai-Mallet
Opublikowane w: Springer Nature, 2024
Wydawca: Springer

Osteogenesis imperfecta and related diseases – collagen I alterations in skeletal and extraskeletal tissues

Autorzy: Giulio Gatto, WendyPérez Franco, Heike-Katharina Hoyer-Kuhn, Oliver Semle, Antonella Forlino, Roberta Besio
Wydawca: Springer Nature

Skeletal Dysplasias Caused by Defects in Glycosaminoglycan Sulfation

Autorzy: Chiara Gramegna Tota, Alessandra Leone, Chiara Paganini, Asifa Khan, Antonio Rossi, Andrea Superti-Furga
Opublikowane w: Biology of Extracellular Matrix, The Extracellular Matrix in Genetic Skeletal Disorders, 2024
Wydawca: Springer Nature Switzerland
DOI: 10.1007/978-3-031-70835-0_6

Mitochondrial dysfunction plays a key role in premature musculoskeletal aging in hypochondroplasia mouse model

Autorzy: Chantal Fayad, Michal Tamáš, Giulio Gatto, Dimitrije Milunov, Soham Saha, Paolo Bonaldo, Frank Zaucke and Laurence Legeai-Mallet, PhD
Opublikowane w: 2026
Wydawca: JBMR

Role of Fgf Signaling in Hypochondroplasia Mouse Model During Aging

Autorzy: Chantal Fayad, Camille Viaut, Michal Tamáš, Paolo Bonaldo and Laurence Legeai-Mallet, PhD
Opublikowane w: 2025
Wydawca: JBMR

Defective Memory is restored and Epileptic seizures are rescued in a Mouse Model of Hypochondroplasia by the FGFR Inhibitor Infigratinib

Autorzy: Chantal Fayad, Lea Loisay, Charline Vilpreux, Stéphanie Moriceau, Franck Oury, Genevieve Baujat, Nathalie Boddaert, Laurence Legeai-Mallet
Opublikowane w: 2026
Wydawca: JBMR

The Extracellular Matrix in Genetic Skeletal Disorders

Opublikowane w: Biology of Extracellular Matrix, 2024
Wydawca: Springer Nature Switzerland
DOI: 10.1007/978-3-031-70835-0

Wyszukiwanie danych OpenAIRE...

Wyniki projektu

Rezultaty

Publikacje

Pobierz Pobierz zawartość strony