Discovering Collagen I degradation process in chronic diseases with fibrotic component

Project Information

DisCo-I

Grant agreement ID: 101072828

DOI

10.3030/101072828

EC signature date 7 June 2022

Start date 1 September 2022

End date 31 August 2026

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 1 648 915,20

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Launch of the project website and social media accounts

Publications

Peer reviewed articles (14)

Assessment and Risk Prediction of Chronic Kidney Disease and Kidney Fibrosis Using Non-Invasive Biomarkers

Author(s): Harald Rupprecht, Lorenzo Catanese, Kerstin Amann, Felicitas E. Hengel, Tobias B. Huber, Agnieszka Latosinska, Maja T. Lindenmeyer, Harald Mischak, Justyna Siwy, Ralph Wendt, Joachim Beige
Published in: International Journal of Molecular Sciences, Issue 25, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms25073678

Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios

Author(s): Keller F, Beige J, Siwy J, Mebazaa A, An D, Mischak H, Schanstra JP, Mokou M, Perco P, Staessen JA, Vlahou A, Latosinska A
Published in: Journal of Translational Medicine, 2023, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-023-04508-6

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

Author(s): Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget
Published in: FEBS Open Bio, Issue 15, 2025, ISSN 2211-5463
Publisher: Wiley
DOI: 10.1002/2211-5463.70043

Association of Urinary Collagen Type III Degradation Product With Kidney Function and Fibrosis in Chronic Kidney Disease Patients

Author(s): Emily M. Martin, Federica Genovese, Harald Mischak, Justyna Siwy, Harald Rupprecht, Lorenzo Catanese, Agnieszka Latosinska
Published in: PROTEOMICS, 2025, ISSN 1615-9853
Publisher: Wiley
DOI: 10.1002/PMIC.202400354

Clinical Proteomics, Quo Vadis?

Author(s): Harald Mischak, Joost P. Schanstra, Antonia Vlahou, Joachim Beige
Published in: PROTEOMICS, Issue 25, 2025, ISSN 1615-9853
Publisher: Wiley
DOI: 10.1002/PMIC.202400346

Circulating collagen type I fragments as specific biomarkers of cardiovascular outcome risk: Where are the opportunities?

Author(s): Emily M. Martin, Joan Chang, Arantxa González, Federica Genovese
Published in: Matrix Biology, Issue 137, 2025, ISSN 0945-053X
Publisher: Elsevier BV
DOI: 10.1016/J.MATBIO.2025.03.001

Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study

Author(s): Jaimes Campos MA, Andújar I, Keller F, Mayer G, Rossing P, Staessen JA, Delles C, Beige J, Glorieux G, Clark AL, Mullen W, Schanstra JP, Vlahou A, Rossing K, Peter K, Ortiz A, Campbell A, Persson F, Latosinska A, Mischak H, Siwy J, Jankowski J
Published in: Pharmaceuticals (Basel), 2023, ISSN 1424-8247
Publisher: MDPI
DOI: 10.3390/PH16091298

Multiple urinary peptides display distinct sex-specific distribution

Author(s): Mina IK, Mavrogeorgis E, Siwy J, Stojanov R, Mischak H, Latosinska A, Jankowski V
Published in: Proteomics, 2013, ISSN 1615-9861
Publisher: Wiley VCH
DOI: 10.1002/pmic.202300227

Reviewing the Regulators of COL1A1

Author(s): Devos H, Zoidakis J, Roubelakis MG, Latosinska A, Vlahou A
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: MDPI
DOI: 10.3390/ijms241210004

Cafeteria Diet-Induced Obesity Worsens Experimental CKD

Author(s): Laget J, Cortijo I, Boukhaled JH, Muyor K, Duranton F, Jover B, Raynaud F, Lajoix AD, Argilés À, Gayrard N
Published in: Nutrients, 2023, ISSN 2072-6643
Publisher: MDPI
DOI: 10.3390/nu15153331

The Omics‐Driven Machine Learning Path to Cost‐Effective Precision Medicine in Chronic Kidney Disease

Author(s): Marta B. Lopes, Roberta Coletti, Flore Duranton, Griet Glorieux, Mayra Alejandra Jaimes Campos, Julie Klein, Matthias Ley, Paul Perco, Alexia Sampri, Aviad Tur‐Sinai
Published in: PROTEOMICS, 2025, ISSN 1615-9853
Publisher: Wiley
DOI: 10.1002/pmic.202400108

Urinary peptide analysis to predict the response to blood pressure medication

Author(s): Jaimes Campos MA, Mavrogeorgis E, Latosinska A, Eder S, Buchwinkler L, Mischak H, Siwy J, Rossing P, Mayer G, Jankowski J
Published in: Nephrology Dialysis Transplantation, 2023, ISSN 1460-2385
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfad223

A Naturally Occurring Urinary Collagen Type I Alpha 1-Derived Peptide Inhibits Collagen Type I-Induced Endothelial Cell Migration at Physiological Concentrations

Author(s): Hanne Devos, Ioanna K. Mina, Foteini Paradeisi, Manousos Makridakis, Aggeliki Tserga, Marika Mokou, Jerome Zoidakis, Harald Mischak, Antonia Vlahou, Agnieszka Latosinska, Maria G. Roubelakis
Published in: International Journal of Molecular Sciences, Issue 26, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS26157480

Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease

Author(s): Ioanna K. Mina, Luis F. Iglesias‐Martinez, Matthias Ley, Lucas Fillinger, Paul Perco, Justyna Siwy, Harald Mischak, Vera Jankowski
Published in: PROTEOMICS, 2024, ISSN 1615-9853
Publisher: Wiley
DOI: 10.1002/pmic.202400279

Other (1)

A synthetic data generation pipeline to reproducibly mirror high-resolution multi-variable peptidomics and real-patient clinical data

Author(s): Mayra Alejandra Jaimes Campos, Stipe Kabić, Agnieszka Latosinska, Ena Anicic, Justyna Siwy, Vinko Dragušica, Harald Rupprecht, Lorenzo Catanese, Felix Keller, Paul Perco, Enrique Gomez- Gomez, Joachim Beige, Antonia Vlahou, Harald Mischak, Davorin Vukelić, Tomislav Križan, Maria Frantzi
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.30.24316342