Project description
Inspiring young scientists in CAR T-cell engineering
There is a way to get immune cells to fight cancer. Chimeric antigen receptor (CAR) T-cell therapy collects the T cells from the patient and makes a small change to the cells. These specially altered T cells fight cancer. In this context, the Marie Skłodowska-Curie Actions project InnoCAR-T will provide training and carry out breakthrough research to develop next-generation CAR-T therapy. Specifically, the project will develop innovative manufacturing solutions for CAR-T production. It will also develop the next generation of more effective CAR-Ts. The project is designed to assist young scientists in generating breakthrough ideas in immunology, CAR engineering and gene editing.
Objective
InnoCAR-T is a Doctoral Network designed to provide training and carry out breakthrough research on the high impact field of Chimeric Antigen Receptor (CAR) T cell immunotherapy in a carefully integrated academic and inter-sectoral programme. We aim to develop next-generation CAR-T therapy and deliver a set of young researchers uniquely qualified for a career in academia and/or industry.
CAR-T cell therapy represents a revolutionary advance in oncology, particularly for B cell lymphoma patients. However, long-term response is still restricted to ~50% of patients, with resistance being even more prominent in other cancers. Thus, additional innovations to overcome resistance are needed to improve CAR-T responses. Unfortunately, the currently centralized production of CAR-T hampers rapid innovation and associates with prohibitive costs, long vein-to-vein time, and poor carbon footprint due to inter-continental delivery.
InnoCAR-T aims touse innovative academic and industrial concepts to address these issues by 1. developing innovative manufacturing solutions for CAR-T production at local academic hospitals and 2. developing the next-generation of more effective CAR-Ts.
At the core of InnoCAR-T is its training objective to offer a cutting-edge multidisciplinary training programme. Herewith, outstanding young scientists can generate breakthrough ideas and assume leading positions in academia and industry. The training programme includes an array of disciplines, ranging from biomedical sciences (e.g. immunology, CAR engineering, gene-editing), physical sciences to mechanical engineering.
Industrial partners are central to the programme and provide pivotal expertise on how to translate scientific discoveries into commercial reality. Inter-sectoral partners will host Doctoral Candidates, provide key secondments and network-wide training events. Further, InnoCAR-T will foster long-term multi-disciplinary research and bilateral co-operations between academia and industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9713 GZ Groningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.