Projektbeschreibung
Junge Forschende für die Entwicklung von CAR-T-Zellen begeistern
Es gibt eine Möglichkeit, Immunzellen dazu zu bringen, Krebs zu bekämpfen. Bei der chimären Antigenrezeptor-T-Zelltherapie (CAR-T-Zelltherapie) werden die T-Zellen der betroffenen Person entnommen und geringfügig verändert. Diese speziell veränderten T-Zellen bekämpfen Krebs. In diesem Zusammenhang wird das über die Marie-Skłodowska-Curie-Maßnahmen unterstützte Projekt InnoCAR-T Schulungen anbieten und bahnbrechende Forschungsarbeiten zur Entwicklung der nächsten Generation der CAR-T-Therapie durchführen. Im Rahmen des Projekts werden insbesondere innovative Lösungen für die CAR-T-Produktion ausgearbeitet. Außerdem wird die nächste Generation wirksamerer CAR-Ts entwickelt. Das Projekt soll junge Wissenschaftlerinnen und Wissenschaftler bei der Entwicklung bahnbrechender Ideen in den Bereichen Immunologie, CAR-Technik und Genomeditierung unterstützen.
Ziel
InnoCAR-T is a Doctoral Network designed to provide training and carry out breakthrough research on the high impact field of Chimeric Antigen Receptor (CAR) T cell immunotherapy in a carefully integrated academic and inter-sectoral programme. We aim to develop next-generation CAR-T therapy and deliver a set of young researchers uniquely qualified for a career in academia and/or industry.
CAR-T cell therapy represents a revolutionary advance in oncology, particularly for B cell lymphoma patients. However, long-term response is still restricted to ~50% of patients, with resistance being even more prominent in other cancers. Thus, additional innovations to overcome resistance are needed to improve CAR-T responses. Unfortunately, the currently centralized production of CAR-T hampers rapid innovation and associates with prohibitive costs, long vein-to-vein time, and poor carbon footprint due to inter-continental delivery.
InnoCAR-T aims touse innovative academic and industrial concepts to address these issues by 1. developing innovative manufacturing solutions for CAR-T production at local academic hospitals and 2. developing the next-generation of more effective CAR-Ts.
At the core of InnoCAR-T is its training objective to offer a cutting-edge multidisciplinary training programme. Herewith, outstanding young scientists can generate breakthrough ideas and assume leading positions in academia and industry. The training programme includes an array of disciplines, ranging from biomedical sciences (e.g. immunology, CAR engineering, gene-editing), physical sciences to mechanical engineering.
Industrial partners are central to the programme and provide pivotal expertise on how to translate scientific discoveries into commercial reality. Inter-sectoral partners will host Doctoral Candidates, provide key secondments and network-wide training events. Further, InnoCAR-T will foster long-term multi-disciplinary research and bilateral co-operations between academia and industry.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksKoordinator
9713 GZ Groningen
Niederlande