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Protease‐guided tumor targeting tools to revolutionize cancer diagnosis and treatment.

Objective

Europe has a high cancer burden: in 2020, 2.7 million EU citizens were diagnosed with the disease and 1.3 million lost their lives to it. This toll is expected to increase further, mainly because Europe's population is ageing: by 2035, cancer will be the leading cause of death in the EU. In 2021, the EC published its ‘Europe's Beating Cancer Plan’ (EBCP), calling for a big push in cancer research. Cancer diagnostics and therapeutics should rapidly become more effective and selective, patient-friendly and personalized.

All these goals are directly addressed by developing better tumor targeting strategies. Typically, they consist of equipping diagnostics and therapeutics with a vector unit. The vector unit binds to a protein that is overexpressed on cancer cells or in the Tumor Micro-Environment (TME), causing the diagnostic or therapeutic payload to accumulate in the tumor. Over the last decades, huge effort has gone in approaches that use antibodies as vectors, but return-on-investment has overall been rather poor. Exciting, recent innovations rely on small molecule vectors that target TME proteases. Proteases are ideal candidates for tumor targeting: they are often strongly overexpressed in the TME and possess an active site that allows high-affinity anchoring of vectors. Members of this consortium have played a leading role in these developments.

OncoProTools wants to force breakthroughs in cancer diagnosis and therapy by:
1) Exploring innovative venues for protease targeting in CAR T cell therapy.
2) Discovering novel vectors that bind to other TME proteases: cathepsins S, B, L and granzyme B
3) Personalize applications of protease targeting: deliver innovative diagnostics through deeper understanding of TME biology.

At the same time, OncoProTools will deliver a training program that truly captures the MSCA values, to 10 Doctoral Candidates. They will be provided with all capabilities to become leaders of tomorrow's R&I in Europe.

Coordinator

UNIVERSITEIT ANTWERPEN
Net EU contribution
€ 525 240,00
Address
Prinsstraat 13
2000 Antwerpen
Belgium

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Region
Vlaams Gewest Prov. Antwerpen Arr. Antwerpen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data

Participants (7)

KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 301 788,00
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data
HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV
Germany
Net EU contribution
€ 260 539,20
Address
Bautzner Landstrasse 400
01328 Dresden

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Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
No data
JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Germany
Net EU contribution
€ 260 539,20
Address
Saarstrasse 21
55122 Mainz

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data
CROMED KUTATO ES SZOLGALTATO KOZPONTOK KFT
Hungary
Net EU contribution
€ 228 348,00
Address
Baross Utca 91 95
1047 Budapest

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Közép-Magyarország Budapest Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
No data
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 251 971,20
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
No data
Faculdade de Farmácia da Universidade de Lisboa
Portugal
Net EU contribution
€ 243 403,20
Address
Av. Prof. Gama Pinto
1649-003 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data
CELLPLY SRL
Italy
Net EU contribution
€ 259 437,60
Address
Via Fondazza 53
40125 Bologna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Emilia-Romagna Bologna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
No data