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Learning from animals how to regenerate: multidisciplinary training programme in regenerative biology

Project description

DEENESFRITPL

Research training network in regenerative biology

Human regenerative abilities are limited, while some animals have remarkable regenerative capacities. Identification of the common principles of regenerative processes in animal models can lead to the improvement of regenerative interventions in humans. Funded by the Marie Skłodowska-Curie Actions programme, the REGENERATE-IT project will merge a spectrum of disciplines to create a research training network for young scientists in regenerative biology. The network will include researchers working on different regenerative model organisms, such as flatworms, cnidarians, crustaceans, amphibians and zebrafish, stem cell specialists working on mouse and human models, industry partners, and experts in bio-analytical technologies. The project trainees will obtain a broad understanding of the fundamentals of regenerative biology and the potential of regenerative medicine.

Objective

The REGENERATE-IT Network brings together a full spectrum of disciplines – from fundamental to applied research – to train the next generation of researchers in regenerative biology and adjacent fields. While the natural regenerative ability of humans is limited, some animals have remarkable regenerative capacity. For example, planarian flatworms can restore all body parts from small pieces of tissue, salamanders can grow back lost limbs and repair damaged eyes, and zebrafish can regenerate their heart and fins. By identifying the common biological principles underlying the regenerative processes in these different animal models, we can learn a great deal on how to improve regenerative interventions in humans. Currently, regenerative animal models are studied in isolation, preventing the discovery of such shared mechanisms, and the REGENERATE-IT Network fills this gap. ESRs trained by REGENERATE-IT will obtain a broad and unique understanding of the fundamentals of regenerative biology and of the needs of research in regenerative medicine. The REGENERATE-IT Network therefore includes scientists working on regenerative model organisms such as flatworms, cnidarians, crustaceans, amphibians and zebrafish; stem cell scientists working on mouse and human models; scientists with impressive track records in translational research and experience with clinical trials; and experts in key technologies such as genomics, single cell sequencing, imaging and drug screening. REGENERATE-IT will train 10 ESRs and 1 associated doctoral researcher through research, secondments to other laboratories, consortium meetings, and workshops covering a wide range of topics. In addition to consolidating European strengths in regenerative biology, and training a cohort of next-generation scientists capable of cross-disciplinary research, REGENERATE-IT will combine and deliver theoretical and technological breakthroughs, and advance the frontiers of regenerative biology and medicine.

Fields of science

Programme(s)

Topic(s)

Call for proposal

HORIZON-MSCA-2021-DN-01

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Funding Scheme

HORIZON-AG-UN - HORIZON Unit Grant

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Net EU contribution
€ 274 370,40
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,00

Participants (8)

Partners (19)

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EC signature date 15 July 2022
Last update: 5 April 2023

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Permalink: https://cordis.europa.eu/project/id/101073238

European Union, 2023