Project description DEENESFRITPL Training network for the development of novel antibiotics to fight antimicrobial resistance Multidrug resistance in bacteria requires urgent development of alternative approaches to discover novel antibiotics. Funded by the Marie Skłodowska-Curie Actions programme, the STOP SPREAD BAD BUGS project is a research training consortium that will train 15 early stage researchers in drug development, infectiology, immunology and pharmacology. Carried out by experts, the training will cover topics such as carbohydrate and protein chemistry for drug discovery, mechanisms of action of current antimicrobial compounds, and computational chemistry of the interactions of the novel antibiotics with pathogens. A range of infection models and state-of-the-art imaging tools will enable trainees to determine efficacy in preclinical tests and track the bacteria and antibiotics in these test systems. Show the project objective Hide the project objective Objective STOP SPREAD BAD BUGS is a new multi-disciplinary research/training consortium built to combat the alarming problem of global antimicrobial resistance. Multi-drug resistance (MDR) in bacteria is becoming increasingly common thus urgently calling for alternative approaches to develop and implement novel antibiotics. We envision a definitive solution that will require a paradigm shift. Its foundation shall be the training of a new generation of future 15 Early Stage Researchers (ESRs) by world-renowned experts in the field of drug development, infectiology, immunology and pharmacology. A unique state-of the-art teaching/training pipeline shall be developed across 7 academic and 5 SME partners with complementary expertise in the development and testing of novel approaches to antimicrobial therapy in humans. We shall establish knowledge and expertise on carbohydrate and protein chemistry for the discovery of new drug candidates, while characterizing the underlying mechanism of existing compounds for treatment of microbial infections. Computational modelling shall optimize the interactions of the novel entities with selected pathogens. A range of infection models allows partners to simultaneously determine compound efficacy in pre-clinical settings and investigate the potential effects of the novel antimicrobials on host tissues. State-of-the-art imaging tools will be applied to track the bacteria and novel compounds in these test systems. Uniquely, the pipeline will also determine the pharmacokinetics, and the effects of compounds on host microbiota and host immunity. Understanding the mechanisms of action of the novel antimicrobials shall provide insights into new antimicrobial mechanisms, which may be further exploited in spin-off projects. This approach means that the STOP SPREAD BAD BUGS consortium will deliver uniquely trained, multi- and interdisciplinary ESRs that will take the continuing fight against global MDR safely into the future. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmacokineticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Keywords antimicrobial resistance novel antibiotic solutions antimicrobial peptides non-digestible oligosaccharides computational modelling pharmacokinetics mucosal immunology microbiota Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2021-DN-01-01 - MSCA Doctoral Networks 2021 Call for proposal HORIZON-MSCA-2021-DN-01 See other projects for this call Funding Scheme MSCA-DN - MSCA-DN Coordinator ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Net EU contribution € 548 740,80 Address Dr molewaterplein 40 3015 GD Rotterdam Netherlands See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (13) Sort alphabetically Sort by Net EU contribution Expand all Collapse all TISSUEGNOSTICS GMBH Austria Net EU contribution € 405 496,80 Address Taborstrasse 10/2 1020 Vienna See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Ireland Net EU contribution € 286 488,00 Address College green trinity college D02 CX56 Dublin 2 See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITEIT UTRECHT Netherlands Net EU contribution € 411 555,60 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PHILIPPS UNIVERSITAET MARBURG Germany Net EU contribution € 130 269,60 Address Biegenstrasse 10 35037 Marburg See on map Region Hessen Gießen Marburg-Biedenkopf Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITETET I STAVANGER Norway Net EU contribution € 297 748,80 Address Kjell arholms gate 41 4021 Stavanger See on map Region Norge Vestlandet Rogaland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 HYLOMORPH AG Switzerland Net EU contribution € 446 439,60 Address Technoparkstrasse 1 8005 Zurich See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INBIOSE Belgium Net EU contribution € 262 620,00 Address Technologiepark 82 bus 41 9052 Zwijnaarde See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES Spain Net EU contribution € 251 971,20 Address Ctra c-59 km 12 torre marimon 08140 Caldes de montbui barcelona See on map Region Este Cataluña Barcelona Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Italy Net EU contribution € 129 718,80 Address Via morego 30 16163 Genova See on map Region Nord-Ovest Liguria Genova Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NUTRITION SCIENCES Belgium Net EU contribution € 393 930,00 Address Booiebos 5 9031 Drongen See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MEDRES-MEDICAL RESEARCH GMBH Germany Net EU contribution € 130 269,60 Address Gleueler strasse 50 50931 Koln See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CHEMPRECISE CONSULTORIA BIOTECNOLOGIA PRODUTOS FARMACEUTICOS E IMOBILIARIO LDA Participation ended Portugal Net EU contribution € 0,00 Address Rua da horta nova 6 2560-654 Torres vedras See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Centro (PT) Oeste Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SETLANCE SRL Italy Net EU contribution € 365 100,03 Address Via fiorentina 1 53100 Siena See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ASSOCIAZIONE TOURISM Participation ended Italy Net EU contribution € 0,00 Address Piazza roma 20 00074 Nemi See on map Region Centro (IT) Lazio Roma Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 DES SOLUTIO - SOLUCOES E CONSULTORIA CIENTIFICA LDA Portugal Net EU contribution € 0,00 Address Rua helena felix 20 2 recuado 2820 266 Charneca de caparica See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INNOSO BV Netherlands Net EU contribution € 0,00 Address Ruychrocklaan 68 2597 EP Den haag See on map Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PROGREDUM GMBH Participation ended Germany Net EU contribution € 0,00 Address Otterberger strasse 73 67659 Kaiserslautern See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Rheinland-Pfalz Rheinhessen-Pfalz Kaiserslautern, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITEIT GENT Belgium Net EU contribution € 0,00 Address Sint pietersnieuwstraat 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITY OF GLASGOW United Kingdom Net EU contribution € 0,00 Address University avenue G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Faculdade de Farmácia da Universidade de Lisboa Participation ended Portugal Net EU contribution € 0,00 Address Av. prof. gama pinto 1649-003 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAT AUTONOMA DE BARCELONA Spain Net EU contribution € 0,00 Address Edif a campus de la uab bellaterra cerdanyola v 08193 Cerdanyola del valles See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany Net EU contribution € 0,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MEDIZINISCHE UNIVERSITAET WIEN Austria Net EU contribution € 0,00 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI SIENA Italy Net EU contribution € 0,00 Address Via banchi di sotto 55 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
