Project description
RNA therapy as a cure for vision impairment
Vision impairment represents an increasing global problem, but an effective cure for retinal diseases (RD) does not exist yet. Funded by the Marie Skłodowska-Curie Actions programme, the RETORNA project aims to find treatment for RD based on RNA therapy. The objective is to create RNA profiles for different RD and identify several potential targets that will be used as therapeutic approaches. The selected RNAs will be evaluated for the treatment of different RD, such as macular degeneration and retinitis pigmentosa. The RETORNA consortium, which includes 7 universities and a research institute, will create a research training network. Ten individual projects will be undertaken by ten doctoral candidates, each under the mentorship of highly qualified European scientists, experts in the field.
Objective
Today, vision impairment up to total blindness represents an increasing global problem with significant social and economic impact upon affected patients and society as a whole. Despite the advancing of knowledge on their genetic basis, there is no effective cure for retinal diseases (RD) to date and therefore there is an urgent need to fill this gap.
The present DN “Targeting RNA as an approach for treating retinal disease” (RETORNA) aims to treat RD by using RNA therapy. Among the research objectives, we will study different types of RNA that are expressed in retinal cells. By observing bioinformatic models, cell and tissue cultures, animal models, and human patients, we will be able to create RNA profiles for different RD. This screening will identify several targets that will be used as therapeutic approaches. Then, selected RNAs will be used to treat different RD, such as macular degeneration and retinitis pigmentosa. Furthermore, the potential economic and social impact of such strategies upon European countries will be studied, and the possibility of commercialization will be assessed.
RETORNA proposes breakthrough research, distributed in 10 individual projects, performed by 10 Doctoral Candidates (DCs). Some of the most highly qualified European scientists of the field will supervise those DCs, who will be awarded with a PhD at the end of the program. Moreover, DCs will be provided with different transferable skills, necessary for starting successful careers in academia, but also in other areas: industry, public organizations, non-profit organizations, consultancy, etc.
The RETORNA consortium consists of 8 beneficiaries, including 7 Universities and 1 Research Institute. The consortium will be managed by 5 different boards (research, managing, training, communication, and quality), all of them in continuous communication with the coordinator and with the general assembly.
Fields of science
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
46001 Valencia
Spain
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Participants (8)
Participation ended
04109 Leipzig
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72074 Tuebingen
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03690 Alicante
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34538 Istanbul
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2333 ZA Leiden
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T12 YN60 Cork
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00185 Roma
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6525 GA Nijmegen
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Partners (8)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
28013 Madrid
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1114 AB Amsterdam-Duivendrecht
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
81100 Caserta
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
5258 BG Berlicum
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Y21N226 Enniscorthy
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
52074 Aachen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
46980 Valencia
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
6525 XZ Nijmegen
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