Targeting RNA as an approach for treating retinal disease

Project Information

RETORNA

Grant agreement ID: 101073316

DOI

10.3030/101073316

EC signature date 6 July 2022

Start date 1 February 2023

End date 31 January 2027

Funded under

Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 2 568 425,56

Coordinated by

FUNDACION UNIVERSIDAD CATOLICA DE VALENCIA SAN VICENTE MARTIR
Spain

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Analysis of retinal morphology and physiology in CACD patients and Prph2 mouse as a new model of CACD

Visual acuity will be measured by optomotor test (OMT). Retinal function will be measured by electroretinographic recordings (ERG). Retinal structure and its vascularization will be evaluated by optical coherence tomography (OCT) and OCT angiography (OCTA). Retinal morphology will be analyzed by different immunohistochemical stains in a cross-sectional retinal cryosections.

Publications

miR-429 RNA therapy as generic strategy to protect against photoreceptor loss

Author(s): Jan Wijnholds
Published in: Molecular Therapy Nucleic Acids, Issue 36, 2025, ISSN 2162-2531
Publisher: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102477

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Author(s): Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Published in: International Journal of Molecular Medicine, Issue 57, 2025, ISSN 1107-3756
Publisher: Spandidos Publications
DOI: 10.3892/IJMM.2025.5722

The Future of Nanomaterials Tackling the Challenge of Delivering Nucleic Acids to the Retina

Author(s): Adams, Friederike; Hurst, Jose; Schnichels, Sven
Published in: Advanced Functional Materials, Issue 35, 2025, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ADFM.202407173

miR-205-5p Modulates High Glucose-Induced VEGFA Levels in Diabetic Mice and ARPE-19 Cells

Author(s): María Ybarra, Miriam Martínez-Santos, Maria Oltra, María Muriach, Maria E. Pires, Chiara Ceresoni, Javier Sancho-Pelluz, Jorge M. Barcia
Published in: Antioxidants, Issue 14, 2025, ISSN 2076-3921
Publisher: MDPI AG
DOI: 10.3390/ANTIOX14020218

Role of Exosomal miR-205-5p Cargo in Angiogenesis and Cell Migration

Author(s): Miriam Martínez-Santos, María Ybarra, María Oltra, María Muriach, Francisco J. Romero, Maria E. Pires, Javier Sancho-Pelluz, Jorge M. Barcia
Published in: International Journal of Molecular Sciences, Issue 25, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS25020934

The economic impact of retinal diseases for which gene therapy is emerging: a systematic literature review

Author(s): Claire Willmington, Ann Kirby, Aileen Murphy
Published in: Health Economics Review, Issue 16, 2026, ISSN 2191-1991
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13561-025-00707-7

Circulating microRNAs as biomarkers for diabetic retinopathy stage identification: A DTA systematic review and meta-analysis

Author(s): Miriam Martínez-Santos, María Ybarra, Maria E. Pires, Chiara Ceresoni, Elías Martínez-López, Javier Sancho-Pelluz, Maria Oltra, Jorge M. Barcia
Published in: PLOS One, Issue 20, 2025, ISSN 1932-6203
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0335434

The role of miRNAs in retinal physiology and in Inherited Retinal Disorders

Author(s): Paola Brandi, Maria Zawadzka, Sandro Banfi
Published in: Physiology, 2025, ISSN 1548-9213
Publisher: American Physiological Society
DOI: 10.1152/PHYSIOL.00035.2025

Value in Health

Author(s): C Willmington, A Murphy, A Kirby
Published in: Value in Health, Issue 27, 2024, ISSN 1098-3015
Publisher: Elsevier BV
DOI: 10.1016/J.JVAL.2024.10.665

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Deliverables

Publications

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