Periodic Reporting for period 1 - ONELAB (Orchestrating next-generation mobile modular laboratories for pandemic monitoring preparedness)
Período documentado: 2022-10-01 hasta 2024-03-31
World expert opinion (WHO) recommends modular laboratory systems for disease monitoring missions; (“Rapid Response Mobile Laboratories” (RRML). ONELAB will develop modular RRML for rapid, flexible, scalable, multi-scenario deployments into the widest range of possible settings. These next-generation facilities will support measurement-technologies/methodologies (for a staged disease detection response) and, through satellite communications, laboratory information systems. Exploiting a panel of acute viral infection biomarkers enables early detection of disease during its asymptomatic incubation. Using this at the outbreak of disease supports effective immediate & targeted public health interventions. Using methodologies developed in response to COVID 19, ONELAB will develop & demonstrate a workflow for semi-autonomous disease-specific biomarker discovery and enhance the capability & capacity of current disease testing strategies.
RRMLs are only as good as the operating teams. Therefore, ONELAB builds world-wide networks & partnerships of experienced experts to define best practice; develop a concept of operation and disseminate this though a pandemic testing playbook and training & networking-events that continue beyond the project. Finally, we will produce a citizen’s guide to mass community testing (MCT) supported by educational outreach resources, to enhance engagement/acceptance from all citizens.
RRMLs are only as good as the operating teams. Therefore, ONELAB builds world-wide networks & partnerships of experienced experts to define best practice; develop a concept of operation and disseminate this though a pandemic testing playbook and training & networking-events that continue beyond the project. Finally, we will produce a citizen’s guide to mass community testing (MCT) supported by educational outreach resources, to enhance engagement/acceptance from all citizens.
We have defined 8 specific and measurable objectives as mentioned in the DoW.
1. End-User direction assessment and evaluation of existing solutions; gaps; and lessons learnt from previous pandemics;
WP5 implemented an in-depth end-user workshop series with complementing qualitative interviews with end-users in six different countries in order to assess existing ways of implementing MCT during the COVID-19 pandemic and document lessons learnt. This information was collected, disseminated within the consortium and integrated in the CONOPS (D3.1). The CONOPS also contains the (interim) outcomes on T2.5 (Policy, legal and ethical aspects of MCT) and T3.2 (GAP analysis).
2. Next Generation modular mobile laboratory systems designed developed and delivered to provide analytical quality by design in accordance with ICH 2 guidelines to meet wide range of monitoring mission goal.
The CONOPS provides a framework to comply with or to take into account for the development of next generation ML. In the Technical file (D5.1) we delivered detailed guidelines and workflows for both clinical studies and FTXs that ensure the implementation of analytical quality by design throughout the project development, validation and testing.
3. Staged diagnostic capability and capacity for delivery of reliable and unambiguous detection and identification of infectious agents across all pandemic phases.
The CONOPS integrates current and future standards (T3.4) to take into account for the next generation ML.
4. ICT and data hub for field data communication and processing to facilitate decision-making by chain of command and authorities
A software solution for a centralized library information storage system (C-LIMS) was designed, implemented and deployed along a corresponding data management plan to enable data collection in the study phase and during planned FTXs.
5. Defining, classifying, and incorporating societal factors, constraints, and heuristics
Results from T2.2 and T2.5 on contextual factors was used as input for D3.1. In WP5 societal factors (inclusiveness, positive patient experience, non-intrusive sampling, etc.) are being incorporated in the definition of FTX scenarios, playbooks and evaluation.
6. Next generation CONOPS for mobile pandemic monitoring operations.
D3.1
7. Establish a worldwide pandemic community-testing forum (WPCTF)
The online forum is operational and accessible via the website: https://onelab-project.eu/(se abrirá en una nueva ventana)
8. Promote international cooperation on pandemics with Japan, build scalable capacities for joint multinational intervention
The Japanese project partner made substantial contributions to this deliverable through the execution of T3.2 which is integrated in D3.1.
1. End-User direction assessment and evaluation of existing solutions; gaps; and lessons learnt from previous pandemics;
WP5 implemented an in-depth end-user workshop series with complementing qualitative interviews with end-users in six different countries in order to assess existing ways of implementing MCT during the COVID-19 pandemic and document lessons learnt. This information was collected, disseminated within the consortium and integrated in the CONOPS (D3.1). The CONOPS also contains the (interim) outcomes on T2.5 (Policy, legal and ethical aspects of MCT) and T3.2 (GAP analysis).
2. Next Generation modular mobile laboratory systems designed developed and delivered to provide analytical quality by design in accordance with ICH 2 guidelines to meet wide range of monitoring mission goal.
The CONOPS provides a framework to comply with or to take into account for the development of next generation ML. In the Technical file (D5.1) we delivered detailed guidelines and workflows for both clinical studies and FTXs that ensure the implementation of analytical quality by design throughout the project development, validation and testing.
3. Staged diagnostic capability and capacity for delivery of reliable and unambiguous detection and identification of infectious agents across all pandemic phases.
The CONOPS integrates current and future standards (T3.4) to take into account for the next generation ML.
4. ICT and data hub for field data communication and processing to facilitate decision-making by chain of command and authorities
A software solution for a centralized library information storage system (C-LIMS) was designed, implemented and deployed along a corresponding data management plan to enable data collection in the study phase and during planned FTXs.
5. Defining, classifying, and incorporating societal factors, constraints, and heuristics
Results from T2.2 and T2.5 on contextual factors was used as input for D3.1. In WP5 societal factors (inclusiveness, positive patient experience, non-intrusive sampling, etc.) are being incorporated in the definition of FTX scenarios, playbooks and evaluation.
6. Next generation CONOPS for mobile pandemic monitoring operations.
D3.1
7. Establish a worldwide pandemic community-testing forum (WPCTF)
The online forum is operational and accessible via the website: https://onelab-project.eu/(se abrirá en una nueva ventana)
8. Promote international cooperation on pandemics with Japan, build scalable capacities for joint multinational intervention
The Japanese project partner made substantial contributions to this deliverable through the execution of T3.2 which is integrated in D3.1.
So far, we identified 12 Key Exploitable Results [KER]. These KERs are a mixture of technical innovations and policy recommendations. During a HORIZON Booster workshop these results will be analysed as it concerns strategies for valorisation.