Description du projet
Les thérapies oculaires et les interventions chirurgicales avancées sous la loupe
La déficience visuelle est une cause majeure de handicap. En Europe, 1 personne sur 30 en moyenne connaît une perte totale ou partielle de la vue. Le traitement des maladies oculaires est une priorité absolue à l’heure actuelle. Cependant, l’arsenal de médicaments se limite toujours aux médicaments traditionnels malgré les progrès des traitements pharmacologiques. Dans ce contexte, le projet DYE-LIGHT, financé par l’UE, envisagera de nouveaux moyens d’administrer des produits biothérapeutiques et de pratiquer la chirurgie oculaire. Outre les méthodes actuelles qui incluent des gouttes oculaires et des injections, le projet envisagera l’utilisation de lasers pulsés à des niveaux d’énergie beaucoup plus bas que ceux utilisés actuellement en chirurgie oculaire, en combinaison avec des colorants vitaux nano-encapsulés utilisés par les chirurgiens pour teindre les tissus.
Objectif
Ocular diseases affect the quality of life of millions of patients. Despite improvements in pharmacological treatments, the arsenal of medications to treat severe ocular diseases today remains rather restricted to traditional drugs. Use of most modern biotherapeutics like proteins and nucleic acids, could be a major step forward. However, current ways of administration such as eye drops and intravitreal injections, are no longer sufficient to deliver these drugs to most targets in the eye. Therefore, novel concepts allowing biotherapeutics to safely overcome ocular barriers are of high interest. In ocular surgery, pulsed-lasers (P-Ls) are used for ‘tissue cutting’, though safety concerns remain. DYE-LIGHT hypothesizes that strategies which would allow the use of P-Ls in the eye at much lower energy than today, could considerably improve safety and pave the way for both novel ocular therapies and advanced surgical interventions. DYE-LIGHT will explore vital dyes, as used by ocular surgeons to stain tissues, as photosensitizers. DYE-LIGHT follows the recent observation that P-L irradiation of ocular dyes can result in the formation of water vapor nanobubbles (‘dye-based nanobubbles’) and thermophoretic transport (‘dye-based thermophoresis’). Interestingly, these biophysical phenomena occur at a laser energy that is ~ 1000 times less than a P-L alone. As compared to free dyes, dyes encapsulated in nanocarriers are expected to penetrate less into the retina, which might improve safety. Therefore, focus in DYE-LIGHT will be on nano-encapsulated ocular dyes. DYE-LIGHT will explore the potential of dye-based nanobubbles for delivery of nucleic acids in the corneal endothelium and for spatial selective vitreolysis in the eye. Finally, DYE-LIGHT will explore dye-based thermophoresis for controlled transport of nanomedicines injected in the vitreous towards the retina. If successful, this might open new perspectives to improve the efficacy of retinal drug and gene delivery.
Champ scientifique
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- medical and health sciencesmedical biotechnologynanomedicine
- medical and health sciencesclinical medicineophthalmology
- medical and health sciencesclinical medicinesurgerysurgical procedures
Mots‑clés
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Thème(s)
Régime de financement
HORIZON-ERC - HORIZON ERC GrantsInstitution d’accueil
9000 Gent
Belgique