Mechano-modulation of tumor microenvironment with mechanotherapeutics and sonopermeation to optimize nano-immunotherapy

Project Information

MMSCancer

Grant agreement ID: 101076425

DOI

10.3030/101076425

EC signature date 23 June 2023

Start date 1 November 2023

End date 31 October 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

KYPRIAKO IDRYMA EREVNON GIA TI MYIKI DISTROFIA
Cyprus

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Drug Delivery

Author(s): Martin, John D; Mpekris, Fotios; Chauhan, Vikash P; Martin, Margaret R; Walsh, Megan E; Stuber, Matthew D; McDonald, Donald M; Yuan, Fan; Stylianopoulos, Triantafyllos; Jain, Rakesh K
Published in: Drug Delivery, 2024, ISSN 1071-7544
Publisher: Taylor & Francis
DOI: 10.6084/M9.FIGSHARE.27873201.V1

Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors

Author(s): Constantina Neophytou, Antonia Charalambous, Chrysovalantis Voutouri, Stella Angeli, Myrofora Panagi, Triantafyllos Stylianopoulos, Fotios Mpekris
Published in: Journal of Controlled Release, Issue 382, 2025, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/J.JCONREL.2025.113722

Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy

Author(s): Mpekris, Fotios; Panagi, Myrofora; Charalambous, Antonia; Voutouri, Chrysovalantis; Stylianopoulos, Triantafyllos
Published in: Cell Reports Medicine, 2024, ISSN 2666-3791
Publisher: Cell Press
DOI: 10.1016/J.XCRM.2024.101626

Breaking barriers: enhancing CAR-armored T cell therapy for solid tumors through microenvironment remodeling

Author(s): Tereza Andreou, Constantina Neophytou, Maria Kalli, Fotios Mpekris, Triantafyllos Stylianopoulos
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1638186

Synergistic mechanotherapy and sonopermeation guided by mathematical modeling for solid tumor treatment

Author(s): Marina Koutsi; Triantafyllos Stylianopoulos; Fotios Mpekris; Fotios Mpekris
Published in: Frontiers in Drug Delivery, 2025, ISSN 2674-0850
Publisher: Frontiers Media S.A.
DOI: 10.3389/FDDEV.2025.1549098

Expanding Immunotherapy Beyond CAR T Cells: Engineering Diverse Immune Cells to Target Solid Tumors

Author(s): Tereza Andreou, Constantina Neophytou, Fotios Mpekris, Triantafyllos Stylianopoulos
Published in: Cancers, Issue 17, 2025, ISSN 2072-6694
Publisher: MDPI AG
DOI: 10.3390/CANCERS17172917

Optimizing therapeutic outcomes with Mechanotherapy and Ultrasound Sonopermeation in solid tumors

Author(s): Marina Koutsi, Triantafyllos Stylianopoulos, Fotios Mpekris
Published in: PLOS Computational Biology, Issue 21, 2025, ISSN 1553-7358
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PCBI.1012676

The synergistic potential of mechanotherapy and sonopermeation to enhance cancer treatment effectiveness

Author(s): Neophytou, Constantina; Stylianopoulos, Triantafyllos; Mpekris, Fotios
Published in: npj Biological Physics and Mechanics, 2025, ISSN 3004-863X
Publisher: Nature / Springer Nature
DOI: 10.1038/S44341-025-00017-3

Neoplasia

Author(s): Fotios Mpekris; Myrofora Panagi; Antonia Charalambous; Chrysovalantis Voutouri; Christina Michael; Antonia Papoui; Triantafyllos Stylianopoulos
Published in: Neoplasia, 2024, ISSN 1522-8002
Publisher: Elsevier
DOI: 10.1016/J.NEO.2024.100990

The mechanopathology of the tumor microenvironment: detection techniques, molecular mechanisms and therapeutic opportunities

Author(s): Stella Angeli; Constantina Neophytou; Maria Kalli; Triantafyllos Stylianopoulos; Fotios Mpekris
Published in: Frontiers in Cell and Developmental Biology, 2025, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/FCELL.2025.1564626