Objective
Living without oxygen is challenging. To live in low-oxygen environments, some microbes exchange nutrients allowing for a division of labor among individuals in a process called syntrophy. Such interactions are often a pre-requisite for prokaryotes living in these environments. Whether syntrophy is necessary for the survival of microbial eukaryotes (protists) is unexplored and yet, critically important to discerning the roles of eukaryotes in nature and how eukaryotic cells adapt to live without oxygen.
TAngO2 will test the hypothesis that syntrophic partnerships allow eukaryotes to thrive in anaerobic environments and underpin the evolution of key eukaryotic cell biological characteristics. This will be accomplished using state-of-the-art genomic, computational, and experimental approaches.
I will discover genes essential for interactions between a model protist and its ectosymbiont using massively-parallelized transposon mutagenesis. This will discern the molecular mechanisms, metabolic interplay, and selective forces dictating eukaryote:prokaryote interactions.
I will deliver metagenomes of cultured anaerobic eukaryote:prokaryote consortia predicted to be engaging in syntrophic interactions. This will drastically expand our knowledge of the biodiversity of eukaryotic genomes and microbial interactions from low-oxygen environments.
I will interrogate the frequency and diversity of syntrophy in eukaryotes by simultaneously sequencing the genomes and transcriptomes ofindividual protist cells and their microbiota sampled from nature. This will provide the first elucidation of what communities co-exist with natural anaerobic protists.
Understanding how syntrophic interactions have influenced eukaryotic cell biology will reveal hidden connections in the complicated functional networks of the eukaryotic cell. TAngO2 will open research avenues by bridging the fields of evolutionary cell biology and microbiology to understand ancient and recent symbiotic
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences biological sciences ecology ecosystems
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
22100 Lund
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.