Gene Therapy for treatment of rare inherited Arrhythmogenic Cardiomyopathy

Project Information

GEREMY

Grant agreement ID: 101080204

DOI

10.3030/101080204

EC signature date 7 April 2023

Start date 1 May 2023

End date 30 April 2027

Funded under

• Health

Total cost

€ 7 774 103,75

EU contribution

€ 7 774 103,75

Coordinated by

STICHTING NETHERLANDS HEART INSTITUTE
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

A data management plan (DMP) will describe how the data will be managed, collected, stored, what standards will be used, and how data will be handled and protected during and after the completion of the project.

Websites, patent fillings, videos etc. (1)

Project Website

We will generate a Project Website to support our Communication and dissemination activities.

Publications

Peer reviewed articles (11)

Plasma proteomics stratification identifies phospholamban R14del carriers at risk for disease progression

Author(s): Frederik E Deiman, Taner Arslan, Remco de Brouwer, Ian Henry, Lars Löfgren, Anders Cavallin, Filippos Michopoulos, Ralf Nilsson, Marcus Henricsson, Christine Ahlstrom, Pia Davidsson, Nils Bomer, Niels Grote Beverborg, Peter van der Meer
Published in: Cardiovascular Research, Issue 122, 2026, ISSN 0008-6363
Publisher: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAG089

The PLN Foundation is striving for a cure, but who owns the disease?

Author(s): Luuk Kerckhaert, Pieter Glijnis, Annet N. Linders, Cor Oosterwijk, Pieter A. Doevendans
Published in: Netherlands Heart Journal, Issue 33, 2025, ISSN 1568-5888
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S12471-025-01961-4

Tools and tactics for studying alternative splicing

Author(s): Rui Sousa-Luís, Maria Carmo-Fonseca
Published in: Nature Reviews Genetics, 2026, ISSN 1471-0056
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41576-026-00952-4

Moral Attitudes on Somatic Gene Editing for Inherited Cardiomyopathy: A Qualitative Interview Study with Key Stakeholders in the Netherlands

Author(s): Jannieke N. Simons, Phaedra Locquet, Pascal Borry, Johannes J. M. van Delden, Rieke van der Graaf
Published in: Journal of Bioethical Inquiry, 2026, ISSN 1176-7529
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S11673-026-10565-5

Phosphoproteomics distinguishes disease-specific mechanisms for human phospholamban cardiomyopathy reversible by RNA therapy

Author(s): Frederik E. Deiman, Nils Bömer, Pia Davidsson, Daniela Später, Annet N. Linders, Itamar B. Dias, Karla F. Arevalo Gomez, Antonio Esquivel Gaytan, Jumo Zhu, Anna Walentinsson, Susanna Engberg, Neil Hattersley, Damla Etal, Christine Ahlstrom, Adam E. Mullick, Kenny M. Hansson, Herman H. W. Silljé, Niels Grote Beverborg, Peter van der Meer
Published in: Signal Transduction and Targeted Therapy, Issue 11, 2026, ISSN 2059-3635
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41392-026-02791-5

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Author(s): Eirini Kyriakopoulou, Danielle Versteeg, Hesther de Ruiter, Ilaria Perini, Fitzwilliam Seibertz, Yannic Döring, Lorena Zentilin, Hoyee Tsui, Sebastiaan J. van Kampen, Malte Tiburcy, Tim Meyer, Niels Voigt, van J. Peter Tintelen, Wolfram H. Zimmermann, Mauro Giacca, Eva van Rooij
Published in: Nature Cardiovascular Research, Issue 2, 2026, ISSN 2731-0590
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44161-023-00378-9

Disparities in access to gene therapy in the European Union: ethical and regulatory challenges

Author(s): Margaux Reckelbus, Riya Mohan, Phaedra Locquet, Eva Van Steijvoort, Isabelle Huys, Pascal Borry
Published in: Journal of Law and the Biosciences, Issue 12, 2025, ISSN 2053-9711
Publisher: Oxford University Press (OUP)
DOI: 10.1093/JLB/LSAF018

Unmet health-related needs of heritable arrhythmogenic cardiomyopathy carriers in Belgium: The UR-HEART survey study

Author(s): Phaedra Locquet, Eva Van Steijvoort, Pascal Borry, Zilke Claessens, Margaux Reckelbus, Tomas Robyns, Isabelle Huys
Published in: Heart Rhythm O2, Issue 6, 2026, ISSN 2666-5018
Publisher: Elsevier BV
DOI: 10.1016/J.HROO.2025.08.029

Insights into Prime Editing Technology: A Deep Dive into Fundamentals, Potentials, and Challenges

Author(s): Seyed Younes Hosseini, Rahul Mallick, Petri Mäkinen, Seppo Ylä-Herttuala
Published in: Human Gene Therapy, Issue 35, 2024, ISSN 1043-0342
Publisher: Mary Ann Liebert Inc
DOI: 10.1089/hum.2024.043

Public perception and willingness to accept somatic gene therapy: A Belgian survey study

Author(s): Phaedra Locquet, Margaux Reckelbus, Eva Van Steijvoort, Pascal Borry, Bram Korbmacher, Sofie Gordts, Lauren Vanceer, Isabelle Huys
Published in: Open Research Europe, Issue 5, 2026, ISSN 2732-5121
Publisher: F1000 Research Ltd
DOI: 10.12688/OPENRESEUROPE.21462.2

Gene Therapy for Heart Failure

Author(s): Hanna Wang, Anni Määttä, Seppo Ylä-Herttuala
Published in: Journal of Cardiovascular Translational Research, Issue 19, 2026, ISSN 1937-5387
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S12265-025-10736-6