Project description
Treating excessive weight gain with tailored prevention and lifestyle interventions
Obesity, a global health crisis, has steadily surged over the years, posing a grave threat to well-being and life expectancy. Despite research strides, treatment efficacy remains limited, underscoring the need for prevention. The EU-funded eprObes project is set to revolutionise the battle against obesity by targeting its roots during early developmental stages. Specifically, the project takes a holistic view, spanning clinical, cognitive, mental health, and lifestyle studies. It delves into the enigmatic early triggers of adult obesity, occurring during prenatal, infantile, and adolescent stages. The project recognises the gender-dependent nature of obesity susceptibility, a facet often overlooked. Through multidisciplinary research, eprObes pinpoints pathogenic mechanisms and metabolic markers, employing bioinformatics and artificial intelligence for data analysis.
Objective
Obesity is one of the main population health threats worldwide, with a sustained increase in prevalence over the last decades and a constellation of co-morbidities that seriously hamper individual wellbeing and life-expectancy. Despite major research efforts, obesity treatments have proven of limited efficacy. Thus, effective prevention strategies are essential to avoid the full spectrum of metabolic complications of overweight during the life-course.
Adult obesity is rooted on early maturational events, including pathophysiological and psychological determinants occurring during the gestational, infantile and/or adolescent periods, which globally remain ill defined. Identification of such early pathogenic mechanisms and markers of metabolic disease is key for active prevention and personalized management of body weight disorders later in life. Of note, pathogenic mechanisms and susceptibility to obesity are seemingly gender-dependent, but this aspect remains underexplored and may compromise effectiveness of preventive measures and treatments tackling obesity and its complications.
eprObes (for early Prevention of Obesity) is a multidisciplinary, patient-centered project, involving clinical studies targeting different maturational windows, coupled with cognitive, mental health, life-style and behavioral studies, as well as mechanistic analyses in suitable preclinical models, whose major aim is to define effective strategies for active prevention of obesity during the life-course, with particular focus on early developmental events, from prenatal (including peri-conceptional) to pubertal periods, and determinants of feeding behaviors. Multi-omics studies and integral analysis of eprObes data, assisted by bioinformatic technologies and artificial intelligence, will permit definition of tailored preventive measures and life-style interventions, at key maturational periods, to avoid excessive body weight gain and lifetime metabolic complications in both sexes.
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HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinator
28029 Madrid
Spain
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Participants (21)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
46014 Valencia
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
14005 Cordoba
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08908 L'Hospitalet De Llobregat
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
14004 Cordoba
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72074 Tuebingen
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3400 Hillerod
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69003 Lyon
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
69003 LYON
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
28033 Madrid
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
75009 PARIS
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28006 Madrid
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31-007 Krakow
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34340 Istanbul
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75654 Paris
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46010 Valencia
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
46010 Valencia
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4000 Liege
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LT-08661 Vilnius
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19003 Guadalajara
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
13419 Tallinn
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35 959 Rzeszow
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