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DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

Project description

DEENESFRITPL

Personalised risk assessment tool to prevent obesity

Obesity poses a significant challenge in the EU, resulting in various health complications. One potential solution lies in adopting the Mediterranean Diet. The EU-funded PAS GRAS project has a clear mission: to prevent and reverse obesity and its associated metabolic issues within four distinct age groups - pre-pubertal children (ages 3-9), adolescents (ages 10-18), young adults (ages 19-25), and adults (ages 25-55). This initiative seeks to proactively identify obesity risks within these critical age brackets by employing a personalised risk assessment tool. PAS GRAS will utilise these identified risk factors to inform new interventional studies. These interventions will incorporate lifestyle adjustments, including the Mediterranean Diet, with the ultimate goal of achieving a 15 % reduction in overweight/obesity prevalence among adults and a 30 % reduction among children and adolescents by the year 2050.

Objective

PAS GRAS aims to prevent and reverse obesity and associated metabolic complications in four age groups: pre-pubertal children (3-9 yr), adolescents (10-18 yr), young adults (19-25 yr), and adults (25-55). PAS GRAS focuses on four main pillars. 1) Develop a personalized risk assessment tool (RAT): an algorithm that will anticipate obesity priming and development in the critical age groups, and identify risk factors for specific complications in subsequent years that will constitute new outcomes for interventional studies. 2) Develop and implement RAT-based personalized interventions by integrating non-pharmacological lifestyle modifications including Mediterranean Diet components alone or with rational pharmacological targeting metabolic and neuroendocrine mechanisms. 3) Inform and engage effectively target groups on obesity causes, risks and intervention by co-production of creative and interactive digital tools (including a simpler version of the RAT) and personalized diet and physical activity programs. 4) Expand and consolidate the PAS GRAS tailor-made campaign across Europe through developing joint programs for health and food/nutrition literacy and physical activity, with healthcare centres, schools, sports clubs, municipalities, and other relevant actors and public authorities. PAS GRAS outcomes will contribute to a long-term 15% decrease in overweight/obesity prevalence in adults and 30% in children/adolescents in the EU until 2050, contributing to a downstream reduction of obesity-associated complications, pharmaceutical and surgical interventions, and to promote Mediterranean Diet as tool for a more nutritious and sustainable future. PAS GRAS is a unique multi- and interdisciplinary research team from 8 countries, including 12 top-level Universities and Research Institutions. Non-academic partners include a civil organization, one company, one patient organization and one Pan-European research Society.

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Call for proposal

HORIZON-HLTH-2022-STAYHLTH-01-two-stage

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Funding Scheme

HORIZON-RIA - HORIZON Research and Innovation Actions

Coordinator

UNIVERSIDADE DE COIMBRA
Net EU contribution
€ 2 383 488,75
Address
PACO DAS ESCOLAS
3004-531 Coimbra
Portugal

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Region
Continente Centro (PT) Região de Coimbra
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 2 383 488,75

Participants (14)

Partners (1)

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Last update: 11 July 2023

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Permalink: https://cordis.europa.eu/project/id/101080329

European Union, 2024