DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

First PDEC version

First version of all actions for DC&E

First version of the Education and Training plan

A document stating all training and education activities across the consortium will be prepared.

Study initiation package

Report detailing the pre-registration (clinicaltrial.gov) of the clinical trial (WP5), final protocol and ethical issues

Pre-registration of animal studies

Report with the pre-registration of in vivo assays (including previous in vitro data)

Report from Kick-Off meeting

A report will be produced, including the compositionof the different boards

Project Website

Public website

Project social media

Report on PAS GRAS social media

Publications

Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies

Author(s): Patrycja Jakubek, Barbara Pakula, Martin Rossmeisl, Paolo Pinton, Alessandro Rimessi, Mariusz Roman Wieckowski
Published in: Internal and Emergency Medicine, Issue 19, 2024, ISSN 1828-0447
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11739-024-03700-w

The role of <scp>CD20</scp><sup>+</sup> T cells: Insights in human peripheral blood

Author(s): Aryane Cruz Oliveira Pinho, Pedro Barbosa, Maria Joo Pereira, Artur Paiva, Eugenia Carvalho, Paula Laranjeira
Published in: Cytometry Part B: Clinical Cytometry, Issue 106, 2024, ISSN 1552-4949
Publisher: Wiley
DOI: 10.1002/cyto.b.22178

Diabetes Alters microRNA Expression in Epicardial and Subcutaneous Adipose Tissue from Patients Undergoing Elective Cardiac Surgery

Author(s): Diana Santos, António Canotilho, Gonçalo Coutinho, David Prieto, Pedro Antunes, Manuel Antunes, Adelino F. Leite Moreira, Inês Falcão-Pires, Eugenia Carvalho, Louise Torp Dalgaard
Published in: Cells, Issue 15, 2026, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/CELLS15020122

Metabolic priming alters the morphology and metabolism of human dermal fibroblasts

Author(s): Pinho, S. A., Barosa, C., Deus, C. M., Jones, J. G., Oliveira, P. J., & Cunha-Oliveira, T. (2025). Metabolic priming alters the morphology and metabolism of human dermal fibroblasts. EXCLI Journal, 24, 1419–1437.
Published in: EXCLI Journal, ISSN 1611-2156
Publisher: EXCLI Journal
DOI: 10.17179/EXCLI2025-8609

Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology

Author(s): Piero Portincasa, Gyorgy Baffy
Published in: European Journal of Internal Medicine, Issue 124, 2024, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2024.04.013

Short-term effects of obesity surgery versus low-energydiet on body composition and tissue-specific glucose uptake: a randomised clinical study using whole-body integrated 18F-FDG-PET/MRI

Author(s): Jan W. Eriksson, Maria J. Pereira, Christakis Kagios, Sofia Kvernby, Elin Lundstrm, Giovanni Fanni, Martin H. Lundqvist, Bjrn C. L. Carlsson, Magnus Sundbom, Sambit Tarai, Mark Lubberink, Joel Kullberg, Ulf Risrus, Hkan Ahlstrm
Published in: Diabetologia, Issue 67, 2024, ISSN 0012-186X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00125-024-06150-3

32nd European Congress on Obesity (ECO 2025)

Author(s): Tuba Avcilar
Published in: Obesity Facts, Issue 18, 2025, ISSN 1662-4025
Publisher: S. Karger AG
DOI: 10.1159/000545547

Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model

Author(s): Susana P. Pereira, Mariana S. Diniz, Ludgero C. Tavares, Teresa Cunha-Oliveira, Cun Li, Laura A. Cox, Mark J. Nijland, Peter W. Nathanielsz, Paulo J. Oliveira
Published in: International Journal of Molecular Sciences, Issue 24, 2023, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms242015192

Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance

Author(s): Argyri Mathioudaki, Giovanni Fanni, Jan W. Eriksson, Maria J. Pereira
Published in: Metabolites, Issue 14, 2024, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo14080411

Rethinking Liver Transaminases to Predict Diabetes Risk in Children With MASLD

Author(s): Melania Manco, Amalia Gastaldelli
Published in: Diabetes Care, Issue 49, 2026, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/DCI25-0135

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Author(s): Fabrizia Carli, Giuseppe Della Pepa, Silvia Sabatini, Antonio Vidal Puig, Amalia Gastaldelli
Published in: JHEP Reports, Issue 6, 2024, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101185

miRNA-642a-3p protects β cells from glucolipotoxicity

Author(s): Sandra Sofia Pinhanços, João Teixeira de Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J.J. de Winter, Sofia Viana, Flávio Reis, Jorge Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferrei
Published in: Molecular Therapy Nucleic Acids, Issue 36, 2025, ISSN 2162-2531
Publisher: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102498

Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes

Author(s): Fozia Ahmed, Susanne Hetty, Rutger Laterveer, Ece Busra Surucu, Argyri Mathioudaki, Edvin Hornbrinck, Vagia Patsoukaki, Johan Olausson, Magnus Sundbom, Maria K Svensson, Maria J Pereira, Jan W Eriksson
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 110, 2025, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/CLINEM/DGAF038

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Author(s): Adriana Fontes, Adrian T. Jauch, Judith Sailer, Jonas Engler, Anabela Marisa Azul, Hans Zischka
Published in: International Journal of Molecular Sciences, Issue 25, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms25147880

Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity

Author(s): Arne Hinrichs, Kalliopi Pafili, Gencer Sancar, Laeticia Laane, Silja Zettler, Malek Torgeman, Barbara Kessler, Judith Leonie Nono, Sonja Kunz, Birgit Rathkolb, Cristina Barosa, Cornelia Prehn, Alexand
Published in: Molecular Metabolism, Issue 103, 2025, ISSN 2212-8778
Publisher: Elsevier BV
DOI: 10.1016/J.MOLMET.2025.102273

What are we missing to gain the battle against cardiovascular diseases?

Author(s): Harshitha Shanmugam, Piero Portincasa, Agostino Di Ciaula
Published in: European Heart Journal, Issue 45, 2024, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae279

Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery

Author(s): Aryane Cruz Oliveira Pinho, Pedro Barbosa, Andr Lazaro, Jos G. Tralho, Maria Joo Pereira, Artur Paiva, Paula Laranjeira, Eugenia Carvalho
Published in: Immunology Letters, Issue 269, 2024, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2024.106911

Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models

Author(s): Mohamad Khalil, Francesca Piccapane, Mirco Vacca, Giuseppe Celano, Laura Mahdi, Valeria Perniola, Carmen Aurora Apa, Alessandro Annunziato, Ilaria Iacobellis, Giuseppe Procino, Maria Calasso, Maria De Angelis, Rosa Caroppo, Piero Portincasa
Published in: Nutrients, Issue 16, 2024, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/nu16050588

Impact of High-Fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease on Heart, Kidney, and Skeletal Muscle Metabolomes in Wild-Type Mice

Author(s): João G. Silva, Ludgero Tavares, Getachew D. Belew, João A. Rodrigues, Rita Araújo, Ana M. Gil, John G. Jones
Published in: Journal of Proteome Research, Issue 24, 2025, ISSN 1535-3893
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.JPROTEOME.5C00040

The interaction of bile acids and gut inflammation influences the pathogenesis of inflammatory bowel disease

Author(s): Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Piero Portincasa
Published in: Internal and Emergency Medicine, Issue 18, 2023, ISSN 1828-0447
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03343-3

BPA Disrupts Hepatic Lipid and Carbohydrate Metabolism in Female Zebrafish: Protective Effects of Probiotics Revealed by FTIRI and Lipidomics

Author(s): Christian Giommi, Chiara Santoni, Fabrizia Carli, Amalia Gastaldelli, Francesca Maradonna, Hamid R. Habibi, Elisabetta Giorgini, Oliana Carnevali
Published in: International Journal of Molecular Sciences, Issue 27, 2026, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS27072978

Tackling overweight and obesity in the youth with the PAS GRAS project

Author(s): Afshan N. Malik, Anabela Marisa Azul, Eugénia Carvalho, John G. Jones, Paulo Matafome, Paulo J. Oliveira, null null
Published in: Nature Medicine, Issue 31, 2025, ISSN 1078-8956
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41591-025-03721-8

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases

Author(s): Mariana S. Diniz, Carina C. Magalhes, Carolina Tocantins, Lus F. Grilo, Jos Teixeira, Susana P. Pereira
Published in: Nutrients, Issue 15, 2023, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/nu15214623

Converging Pathways between Metabolic DysfunctionAssociated Steatotic Liver Disease (MASLD) and Diabetes in Children

Author(s): Maria Felicia Faienza, Ilaria Farella, Mohamad Khalil, Piero Portincasa
Published in: International Journal of Molecular Sciences, Issue 25, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms25189924

Reversal of Diabesity Through Modulating Sympathetic Inputs to Adipose Tissue Following Carotid Body Resection

Author(s): Bernardete F. Melo, Joana F. Sacramento, Julien Lavergne, Fátima O. Martins, Daniela Rosendo‐Silva, Clara Panzolini, Cláudia S. Prego, Aidan Falvey, Elena Olea, Paulo Matafome, Asuncion Rocher, Je
Published in: Acta Physiologica, Issue 241, 2025, ISSN 1748-1708
Publisher: Wiley
DOI: 10.1111/APHA.70074

Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease

Author(s): Mariana S. Diniz, Ursula Hiden, Ins Falco-Pires, Paulo J. Oliveira, Luis Sobrevia, Susana P. Pereira
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1869, 2024, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166834

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Author(s): Mariana S. Diniz, Luís F. Grilo, Carolina Tocantins, Inês Falcão-Pires, Susana P. Pereira
Published in: Metabolites, Issue 13, 2025, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo13070845

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Author(s): Azra Kulovic-Sissawo, Carolina Tocantins, Mariana S. Diniz, Elisa Weiss, Andreas Steiner, Silvija Tokic, Corina T. Madreiter-Sokolowski, Susana P. Pereira, Ursula Hiden
Published in: Biology, Issue 13, 2024, ISSN 2079-7737
Publisher: MDPI AG
DOI: 10.3390/biology13020070

Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review

Author(s): Agostino Di Ciaula, Mohamad Khalil, Gyorgy Baffy, Piero Portincasa
Published in: European Journal of Internal Medicine, Issue 128, 2024, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2024.07.008

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction

Author(s): Daniela Rosendo-Silva, Pedro Bastos Gomes, Tiago Rodrigues, Sofia Viana, Andr Nogueira da Costa, Philipp E. Scherer, Flvio Reis, Francisco Pereira, Raquel Seia, Paulo Matafome
Published in: Metabolism, Issue 153, 2024, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2024.155788

Hepatic glucose metabolism in the steatotic liver

Author(s): Egeria Scoditti, Silvia Sabatini, Fabrizia Carli, Amalia Gastaldelli
Published in: Nature Reviews Gastroenterology & Hepatology, Issue 21, 2024, ISSN 1759-5045
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41575-023-00888-8

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Author(s): LusF. Grilo, JooD. Martins, MarianaS. Diniz, Carolina Tocantins, ChiaraH. Cavallaro, Ins Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, PeterW. Nathanielsz, PauloJ. Oliveira, SusanaP. Pereira
Published in: Clinical Science, Issue 137, 2023, ISSN 0143-5221
Publisher: Portland Press Ltd.
DOI: 10.1042/CS20230048

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

Author(s): Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Mace
Published in: European Journal of Clinical Investigation, Issue 55, 2025, ISSN 0014-2972
Publisher: Wiley
DOI: 10.1111/ECI.70059

Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low‐energy diet

Author(s): Giovanni Fanni, Fleur Hukema, Susanne Hetty, Argyri Mathioudaki, Magnus Sundbom, Ulf Risérus, Joel Kullberg, Maria J. Pereira, Håkan Ahlström, Jan W. Eriksson
Published in: Diabetes, Obesity and Metabolism, Issue 27, 2025, ISSN 1462-8902
Publisher: Wiley
DOI: 10.1111/DOM.16526

Dapagliflozin modulates plasma lipidomic profile and urinary metabolite excretion in type 2 diabetes

Author(s): Samantha Pezzica, Filippo Pratesi, Silvia Sabatini, Fabrizia Carli, Alessandro Mengozzi, Anna Solini, Amalia Gastaldelli
Published in: Cardiovascular Diabetology, Issue 25, 2026, ISSN 1475-2840
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12933-025-03018-7

Mitochondrial DNA – novel mechanisms of kidney damage and potential biomarker

Author(s): Afshan N. Malik
Published in: Current Opinion in Nephrology & Hypertension, Issue 32, 2024, ISSN 1062-4821
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/mnh.0000000000000922

Targeting NRF2 With Isoeugenol: A Promising Small Molecule for Neurodegenerative, Metabolic, and Chronic Inflammatory Disorders

Author(s): Ana Silva, Sónia Silva, Beatriz Rodrigues, Gonçalo Simões, Inês Dinis, Mafalda Freitas, Rosa Resende, Joana Bicker, Ana Fortuna, Maria M. Silva, Armanda E. Santos, Sónia A. Pinho, Bruno Neves, Cl
Published in: Oxidative Medicine and Cellular Longevity, Issue 2025, 2025, ISSN 1942-0900
Publisher: Wiley
DOI: 10.1155/OMCL/7695056

Time to Increase Awareness and Diagnosis of Steatotic Liver Disease in Adolescents

Author(s): Amalia Gastaldelli
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 110, 2025, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/CLINEM/DGAE744

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Author(s): Diana Sousa, CarinaC. Magalhes, Paulo Matafome, SusanaP. Pereira
Published in: Bioscience Reports, Issue 44, 2024, ISSN 0144-8463
Publisher: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Co-regulation and synteny of GFM2 and NSA2 links ribosomal function in mitochondria and the cytosol with chronic kidney disease

Author(s): Minjie Zhang, Christer Hogstrand, Paola Pontrelli, Afshan N Malik
Published in: Molecular Medicine, Issue 30, 2024, ISSN 1528-3658
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s10020-024-00930-8

Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations

Author(s): Piero Portincasa, Agostino Di Ciaula, Leonilde Bonfrate, Alessandro Stella, Gabriella Garruti, John Thomas Lamont
Published in: Internal and Emergency Medicine, Issue 18, 2023, ISSN 1828-0447
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03355-z

Lipidomic profiling unveils sex differences in diabetes risk: Implications for precision medicine

Author(s): Ana F. Pina, Maria João Meneses, Fabrizia Carli, Rogério T. Ribeiro, Luís Gardete‐Correia, José M. Boavida, João F. Raposo, Amalia Gastaldelli, M. Paula Macedo
Published in: European Journal of Clinical Investigation, 2025, ISSN 0014-2972
Publisher: Wiley
DOI: 10.1111/ECI.70137

Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux

Author(s): Heloísa Gerardo, Tânia Lourenço, Júlio Torres, Manuela Ferreira, Célia Aveleira, Susana Simões, Lino Ferreira, Cláudia Cavadas, Paulo J. Oliveira, José Teixeira, Mário Grãos
Published in: European Journal of Clinical Investigation, Issue 55, 2025, ISSN 0014-2972
Publisher: Wiley
DOI: 10.1111/ECI.70051

OBEClust: joining forces to prevent obesity

Author(s): Manuel Tena-Sempere, Dimitrios-Dionyssios Koutsouris, George Dedoussis, Jeroen Lakerveld, Karl-Heinz Wagner, Itziar Tueros, Philippe Froguel, Torsten Bohn, Paulo J. Oliveira
Published in: Nature Reviews Endocrinology, Issue 22, 2026, ISSN 1759-5029
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41574-025-01212-X

Renal sinus adipose tissue: exploratory study of metabolic features and transcriptome compared with omental and subcutaneous adipose tissue

Author(s): Maria J. Pereira, Argyri Mathioudaki, Alicia G. Otero, Padma Priya Duvvuri, Milica Vranic, Amir Sedigh, Jan W. Eriksson, Maria K. Svensson
Published in: Obesity, Issue 32, 2024, ISSN 1930-7381
Publisher: Wiley
DOI: 10.1002/oby.24114

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Author(s): Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202309211

Corrigendum to “The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity” [Mol. Cell. Endocrinol. 594 (2024), 112367]

Author(s): Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Inês Falcão-Pires, Hans Eickhoff, Sofia Viana, Flávio Reis, Ana Salomé Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seiça, Paulo Matafome
Published in: Molecular and Cellular Endocrinology, Issue 595, 2024, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2024.112410

Mitochondria-targeted antioxidant AntiOxBEN2 prevents metabolic dysfunction-associated steatotic liver disease (MASLD) by enhancing fatty acid oxidation and mitochondrial bioenergetics

Author(s): Ricardo Amorim, Carina Magalhães, Ana I. Duarte, Alexandra C. de Lemos, Adriana-Marques Carvalho, Susana P. Pereira, Luís F. Grilo, Débora Mena, Heloísa Gerardo, Caroline Veloso, Diana Sousa, Armando Caseiro, Fernando Cagide, Fernanda Borges, Paulo Matafome, José Teixeira, Paulo J. Oliveira
Published in: Biomedicine & Pharmacotherapy, Issue 196, 2026, ISSN 0753-3322
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPHA.2026.119022

Distinct biophysiological effects of Ramadan fasting and traditional intermittent fasting on markers of body fat storage. A real-life study

Author(s): Mohamad Khalil, Hala Abdallah, Nour Jaber, Gabriella Garruti, Agostino Di Ciaula, Piero Portincasa
Published in: European Journal of Internal Medicine, Issue 129, 2024, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2024.08.014

Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy

Author(s): Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, David Rizo-Roca, Estela Santos-Alves, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1871, 2024, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2024.167539

Metabolic Dysfunction–Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options

Author(s): Piero Portincasa, Mohamad Khalil, Laura Mahdi, Valeria Perniola, Valeria Idone, Annarita Graziani, Gyorgy Baffy, Agostino Di Ciaula
Published in: International Journal of Molecular Sciences, Issue 25, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS25115640

The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity

Author(s): Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Ins Falco-Pires, Hans Eickhoff, Sofia Viana, Flvio Reis, Ana Salom Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seia, Paulo Matafome
Published in: Molecular and Cellular Endocrinology, Issue 594, 2024, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2024.112367

The (un)known crosstalk between metabolism and mechanotransduction: Implications for metabolic syndrome (MetS)-associated neurological complications

Author(s): Heloísa Gerardo, Paulo J. Oliveira, Cláudia Cavadas, Mário Grãos, José Teixeira
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1871, 2025, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/J.BBADIS.2025.167678

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

The case for primary prevention of obesity in the era of GLP-1 therapies

Author(s): Søren Holm, Manuel Tena-Sempere, Dimitrios Koutsouris, George V. Dedoussis, Karl-Heinz Wagner, Sara Arranz, Philippe Froguel, Torsten Bohn, Paulo J. Oliveira, Jeroen Lakerveld, Aakruti Kaikini, Achim Kramer, Adam Selamnia, Adina Weinberger, Adrian Jauch, Adriana Fontes, Adriana Voicu, Adrianna Tryskuc, Afshan Malik, Agnieszka Kozioł-Kozakowska, Agostino Di Ciaula, Agustin Fernandez, Aikaterina Vasileiou, Ainara Cano, Ainhoa Ruano, Alain Massart, Alberto Norhona, Alejandra Loyola Leyva, Aleksandra Davydova, Aleksandra Luszczynska, Ales Wodecki, Alessia D'Andrea, Alex Bravo Serrano, Alexandra Karahaliou, Alexandra Tiganouria, Alexandre Chikalanov, Alexandros Papadopoulos, Alexia Barroso, Alexis Kyriacou, Alfred Wagtendonk, Alice Denis, Alice Maguolo, Alicia Sicardi, Alkyoni Glympi, Alvaro Obeso, Amaia Barrena, Amalia Gastaldelli, Amelia Sarroca, Amëlie Bonnefond, Amine Belfoul, Amy Hough, Ana Cláudia Guedes, Ana Marcela Zapata Castellon, Ana Ochando, Ana Realinho, Ana Rito, Ana Teixeira, Anabel Martinez, Anabela Marisa Azul, Anastasios Delopoulos, Anastasios Papamanolis, Anders Eriksson, Anders Juul, André Lázaro, André Seabra, Andrea Devecchi, Andrea Piano Mortari, Andreas Jespersen, Andreas Vezakis, Andreea Ciudin-Mihai, Andreia Amaro, Andreia Silva, Anestis Dougkas, Aneta Radaczyńska, Angelica Dessì, Angie Jackson-Morris, Anika Kronberger, Anita Morandi, Anna Banik, Anna Brieva-Toloza, Anna Ek, Anna Kornafel, Anna Lena Aufschnaiter, Annalisa Roberti, Anne-Simone Parent, Anne Niknejad, Anneleen Segers, Anneli Rost, Anneline Pinson, Annemarie Olsen, Annette Schürmann, Annica Doersam, Antoni Caimari, António Cruz, Antonio Noto, Apostolos Malatras, Arianna D'Ulizia, Aristides Machado-Rodrigues, Armando Raimundo, Artur Mazur, Astrid Günther, Astrid Kemperman, Athanasia Kyrkili, Athanasios Anastasiou, Athanasios Kakasis, Augustina Jankauskiene, Ausrine Pliauckiene, Belén Pastor-Villaescusa, Benjamin Küther, Benny Lo, Bert Maier, Bianca Fuchs-Neuhold, Biljana Meshkovska, Billy Langlet, Binisha H. Mishra, Birk Schütz, Boshuizen Hendriek, Boyko Doychinov, Bruna Moreira, Bruno Manadas, Carina Magalhães, Carla Faria, Carlos Penha Gonçalves, Carlos Simón, Carmen Sayon-Orea, Carminda Morais, Carolina Ortega-Azorin, Cassandra Omane, Catalina Cuparencu, Catarina Parente, Cathrine Winding, Cátia Barra, Célia Cabral, Charlotte Ehlers Thomsen, Charlotte Jacquinet, Charlotte Ling, Charly Bastiaansen, Chloé Glachet, Christina Aguilar Riera, Christina Barragan Mesa, Christina Höfler, Christina Patmiou, Christine Ellersdorfer, Christine Poitou, Christoph Stahl, Christos Diou, Christos Nikitas, Chrysa Episkopou, Ciro Avolio, Claire Cannet, Cláudia Pereira, Coen Dros, Concepcion Aguilera, Constantinos Deltas, Cristina Barragan Yebra, Cristina Bouzas, Cristina Gora, Cristina Padez, Cristina Piras, Cristina Razquin, Cristinel Gheorghiu, Danai Kyrkou, Danai Malti, Danai Rossiou, Daniela Grach, Daniela Rodrigues, Daniela Rosendo-Silva, Danika Shepis, Darya Silchenko, David Horner, David Thivel, Dawei Chen, Debora Porri, Delfien Gryspeerdt, Desiree Lucassen, Diana Juanita Mora, Diana Sousa, Dimitrios Aletras, Dimitrios Fotiadis, Dimitrios Koutsouris, Dimitrios Tsakalidis, Dimitrios Zaikis, Dimitris Gkoulis, Dimitris Plakas, Djamel Rahmani, Dolores Corella, Domenico Corica, Dominika Malińska, Dominiki Gallou, Dorota Drożdż, Dorota Komar, Dorret I. Boomsma, Edith Feskens, Eduard Mogas Vinals, Eduardo Aguaviva, Eduardo Lopes, Edyta Łuszczki, Egeria Scoditti, Eirini Bathrellou, Eirini Marouli, Eleftheria Vellidou, Elena Ferragut Roig, Elena Jansen, Elena Patra, Elena Santacruz, Eleni Chatzi, Eleni Georga, Eleni Politi, Eleni Ramouzi, Elisabeth Thiering, Ellena Badrick, Elsa Sousa De Lamy, Emiilie de Zoete, Empar Lurbe, Ena Nielsen, Eran Segal, Erica van den Akker, Ermelindo Leal, Eszter Salamon, Eudald Casals Mercadal, Eugénia Carvalho, Eva Karaglani, Eva Schernhammer, Eva Schernhammer, Eva Winzer, Evangelia Charmandari, Evgenia L
Published in: The Lancet Regional Health - Europe, 2026, ISSN 2666-7762
Publisher: Elsevier BV
DOI: 10.1016/J.LANEPE.2026.101679

Oxidative stress in metabolic dysfunctionassociated steatotic liver disease (<scp>MASLD</scp>): How does the animal model resemble human disease?

Author(s): Patrycja Jakubek, Piotr Kalinowski, Agnieszka KarkucinskaWieckowska, Aakruti Kaikini, Ins C. M. Simes, Yaiza Potes, Beata Kruk, Wieslawa Grajkowska, Paolo Pinton, Piotr Milkiewicz, Micha Grt, Maciej Pronicki, Magdalena LebiedzinskaArciszewska, Marcin Krawczyk, Mariusz R. Wieckowski
Published in: The FASEB Journal, Issue 38, 2024, ISSN 0892-6638
Publisher: Wiley
DOI: 10.1096/fj.202302447R

Poliprotect®, a Medical Device Made of Substances, Potently Protects the Human Esophageal Mucosa Challenged by Multiple Agents: Evidence from In Vitro and Ex Vivo Electrophysiological Models

Author(s): Mohamad Khalil, Valeria Perniola, Elisa Lanza, Laura Mahdi, Pierluca Sallustio, Valeria Idone, Daniela Semeraro, Maria Mastrodonato, Mario Testini, Jean-Francois Desaphy, Piero Portincasa
Published in: International Journal of Molecular Sciences, Issue 26, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS26020791

Glucosinolate Derivatives: Emerging Anti-Inflammatory Agents

Author(s): Sandrine Ressurreição, Sónia A. Pinho, Maria Teresa Cruz, Lígia Salgueiro, Artur Figueirinha
Published in: Pharmaceuticals, Issue 19, 2026, ISSN 1424-8247
Publisher: MDPI AG
DOI: 10.3390/PH19050658

Role of FKBP5 in adipose tissue function: Implications for obesity and insulin sensitivity

Author(s): Rutger Laterveer, Susanne Hetty, Argyri Mathioudaki, Martin H. Lundqvist, Maria K. Svensson, Magnus Sundbom, Petros Katsogiannos, Jan W. Eriksson, Maria J. Pereira
Published in: Molecular and Cellular Endocrinology, Issue 613, 2026, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/J.MCE.2025.112718

Multidimensional Assessment of Sarcopenia and Sarcopenic Obesity in Geriatric Patients: Creatinine/Cystatin C Ratio Performs Better than Sarcopenia Index

Author(s): Mohamad Khalil, Agostino Di Ciaula, Nour Jaber, Roberta Grandolfo, Flavia Fiermonte, Piero Portincasa
Published in: Metabolites, Issue 14, 2024, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo14060306

Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction

Author(s): Fleur W Hukema, Susanne Hetty, Christakis Kagios, Sofia Zelleroth, Giovanni Fanni, Maria J Pereira, Maria K Svensson, Magnus Sundbom, Anna Nilsson, Per E Andrén, Erika Roman, Jan W Eriksson
Published in: Translational Research, Issue 280, 2025, ISSN 1931-5244
Publisher: Elsevier BV
DOI: 10.1016/J.TRSL.2025.05.001

Depot-specific metabolic and inflammatory profiles in perirenal and renal sinus adipose tissue

Author(s): Maria J. Pereira, Argyri Mathioudaki, Susanne Hetty, Amir Sedigh, Jan W. Eriksson, Maria K. Svensson
Published in: Molecular Medicine, Issue 31, 2025, ISSN 1528-3658
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S10020-025-01323-1

Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women

Author(s): Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J Pereira, Jan W Eriksson
Published in: Endocrinology, Issue 165, 2023, ISSN 1945-7170
Publisher: The Endocrine Society
DOI: 10.1210/endocr/bqad172

Stage dependent alterations in PBMC mitochondrial bioenergetics in pediatric obesity: from insulin resistance to type 2 diabetes

Author(s): Marlene Rechtsteiner, Susanne Kröber, Samiya Al-Robaiy, Hans Zischka, Andreas Simm, Paulo J. Oliveira, Eugénia Carvalho, Susann Weihrauch-Blüher
Published in: Diabetes Research and Clinical Practice, Issue 237, 2026, ISSN 0168-8227
Publisher: Elsevier BV
DOI: 10.1016/J.DIABRES.2026.113300

Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?

Author(s): Piero Portincasa, Mohamad Khalil, Annarita Graziani, Gema Frhbeck, Gyorgy Baffy, Gabriella Garruti, Agostino Di Ciaula, Leonilde Bonfrate
Published in: European Journal of Internal Medicine, Issue 119, 2024, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2023.10.002

Metabolic mitochondrial alterations prevail in the female rat heart 8weeks after exercise cessation

Author(s): Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena StevanovicSilva, Jorge Beleza, Pedro Coxito, David RizoRoca, Estela SantosAlves, Manoel Rios, Lina Carvalho, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Published in: European Journal of Clinical Investigation, Issue 53, 2023, ISSN 0014-2972
Publisher: Wiley
DOI: 10.1111/eci.14069

Proteomic Profiling of Plasma- and Gut-Derived Extracellular Vesicles in Obesity

Author(s): Pedro Baptista Pereira, Estefania Torrejón, Inês Ferreira, Ana Sofia Carvalho, Akiko Teshima, Inês Sousa-Lima, Hans Christian Beck, Bruno Costa-Silva, Rune Matthiesen, Maria Paula Macedo, Rita Machado de Oliveira
Published in: Nutrients, Issue 16, 2024, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/nu16050736

PASGRAS_Comic_Food powers your body_Adolescents_PL

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19591906

PASGRAS_Bookmark_Enfolding lives of health and joy_General Public_ENG

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19692098

PASGRAS_Comic_Food powers your body_Adolescents_IT

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19591421

PASGRAS_Comic_Food powers your body_Adolescents_PT

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19592197

PASGRAS_Bookmark_Enfolding lives of health and joy_General Public_PT

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19692339

PASGRAS_Comic_Food powers your body_Adolescents_ES

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19591231

PASGRAS_Comic_Food powers your body_Adolescents_DE

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19590916

PASGRAS_Comic_Food powers your body_Adolescents_ENG

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19590714

PASGRAS_Comic_Food powers your body_Adolescents_SWE

Author(s): Anabela Marisa Azul, Andreia F. Silva, João Ramalho-Santos, Rui Tavares
Published in: 2026
Publisher: PAS GRAS
DOI: 10.5281/ZENODO.19592593

Characterization of the Mitochondria Function and Metabolism in Skin Fibroblasts Using the Biolog MitoPlate S-1

Author(s): Alexandra C. de Lemos, José Teixeira, Teresa Cunha-Oliveira
Published in: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2025
Publisher: Springer US
DOI: 10.1007/978-1-0716-4264-1_5

Absolute Quantification of Cellular and Cell-Free Mitochondrial DNA Copy Number from Human Blood and Urinary Samples Using Real Time Quantitative PCR

Author(s): Eliane Caseiro Soares de Menezes, Afshan Navid Malik
Published in: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2025
Publisher: Springer US
DOI: 10.1007/978-1-0716-4264-1_13

Absolute Quantification of Cellular and Cell-Free Mitochondrial DNA Copy Number from Human Blood and Urinary Samples Using Real Time Quantitative PCR

Author(s): Eliane Caseiro Soares de Menezes, Afshan Navid Malik
Published in: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2024
Publisher: Springer US
DOI: 10.1007/978-1-0716-4264-1_13

ANIA: 3D Asset Generation Engine

Author(s): Mariana Reis, João Quintas, Paulo Menezes
Published in: Proceedings of the 21st International Conference on Computer Graphics, Interaction and Visualization Theory and Applications, 2026
Publisher: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0014334500004728

Searching for OpenAIRE data...

Deliverables

Publications

Download Download the content of the page