DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

Project Information

PAS GRAS

Grant agreement ID: 101080329

DOI

10.3030/101080329

EC signature date 28 April 2023

Start date 1 May 2023

End date 30 April 2028

Funded under

• Health

Total cost

€ 9 377 421,25

EU contribution

€ 9 377 421,25

Coordinated by

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (5)

First PDEC version

First version of all actions for DC&E

First version of the Education and Training plan

A document stating all training and education activities across the consortium will be prepared.

Study initiation package

Report detailing the pre-registration (clinicaltrial.gov) of the clinical trial (WP5), final protocol and ethical issues

Pre-registration of animal studies

Report with the pre-registration of in vivo assays (including previous in vitro data)

Report from Kick-Off meeting

A report will be produced, including the compositionof the different boards

Data Management Plan (1)

Data management plan

A data management plan will be prepared by allpartners. Updated whenever necessary

Websites, patent fillings, videos etc. (2)

Project Website

Public website

Project social media

Report on PAS GRAS social media

Publications

Peer reviewed articles (38)

Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies

Author(s): Patrycja Jakubek, Barbara Pakula, Martin Rossmeisl, Paolo Pinton, Alessandro Rimessi, Mariusz Roman Wieckowski
Published in: Internal and Emergency Medicine, Issue 19, 2024, ISSN 1828-0447
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11739-024-03700-w

The role of <scp>CD20</scp>⁺ T cells: Insights in human peripheral blood

Author(s): Aryane Cruz Oliveira Pinho, Pedro Barbosa, Maria Joo Pereira, Artur Paiva, Eugenia Carvalho, Paula Laranjeira
Published in: Cytometry Part B: Clinical Cytometry, Issue 106, 2024, ISSN 1552-4949
Publisher: Wiley
DOI: 10.1002/cyto.b.22178

Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology

Author(s): Piero Portincasa, Gyorgy Baffy
Published in: European Journal of Internal Medicine, Issue 124, 2024, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2024.04.013

Short-term effects of obesity surgery versus low-energydiet on body composition and tissue-specific glucose uptake: a randomised clinical study using whole-body integrated 18F-FDG-PET/MRI

Author(s): Jan W. Eriksson, Maria J. Pereira, Christakis Kagios, Sofia Kvernby, Elin Lundstrm, Giovanni Fanni, Martin H. Lundqvist, Bjrn C. L. Carlsson, Magnus Sundbom, Sambit Tarai, Mark Lubberink, Joel Kullberg, Ulf Risrus, Hkan Ahlstrm
Published in: Diabetologia, Issue 67, 2024, ISSN 0012-186X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00125-024-06150-3

Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model

Author(s): Susana P. Pereira, Mariana S. Diniz, Ludgero C. Tavares, Teresa Cunha-Oliveira, Cun Li, Laura A. Cox, Mark J. Nijland, Peter W. Nathanielsz, Paulo J. Oliveira
Published in: International Journal of Molecular Sciences, Issue 24, 2023, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms242015192

Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance

Author(s): Argyri Mathioudaki, Giovanni Fanni, Jan W. Eriksson, Maria J. Pereira
Published in: Metabolites, Issue 14, 2024, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo14080411

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Author(s): Adriana Fontes, Adrian T. Jauch, Judith Sailer, Jonas Engler, Anabela Marisa Azul, Hans Zischka
Published in: International Journal of Molecular Sciences, Issue 25, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms25147880

What are we missing to gain the battle against cardiovascular diseases?

Author(s): Harshitha Shanmugam, Piero Portincasa, Agostino Di Ciaula
Published in: European Heart Journal, Issue 45, 2024, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae279

Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery

Author(s): Aryane Cruz Oliveira Pinho, Pedro Barbosa, Andr Lazaro, Jos G. Tralho, Maria Joo Pereira, Artur Paiva, Paula Laranjeira, Eugenia Carvalho
Published in: Immunology Letters, Issue 269, 2024, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2024.106911

Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models

Author(s): Mohamad Khalil, Francesca Piccapane, Mirco Vacca, Giuseppe Celano, Laura Mahdi, Valeria Perniola, Carmen Aurora Apa, Alessandro Annunziato, Ilaria Iacobellis, Giuseppe Procino, Maria Calasso, Maria De Angelis, Rosa Caroppo, Piero Portincasa
Published in: Nutrients, Issue 16, 2024, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/nu16050588

The interaction of bile acids and gut inflammation influences the pathogenesis of inflammatory bowel disease

Author(s): Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Piero Portincasa
Published in: Internal and Emergency Medicine, Issue 18, 2023, ISSN 1828-0447
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03343-3

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases

Author(s): Mariana S. Diniz, Carina C. Magalhes, Carolina Tocantins, Lus F. Grilo, Jos Teixeira, Susana P. Pereira
Published in: Nutrients, Issue 15, 2023, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/nu15214623

Converging Pathways between Metabolic DysfunctionAssociated Steatotic Liver Disease (MASLD) and Diabetes in Children

Author(s): Maria Felicia Faienza, Ilaria Farella, Mohamad Khalil, Piero Portincasa
Published in: International Journal of Molecular Sciences, Issue 25, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms25189924

Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease

Author(s): Mariana S. Diniz, Ursula Hiden, Ins Falco-Pires, Paulo J. Oliveira, Luis Sobrevia, Susana P. Pereira
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1869, 2024, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166834

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Author(s): Mariana S. Diniz, Luís F. Grilo, Carolina Tocantins, Inês Falcão-Pires, Susana P. Pereira
Published in: Metabolites, Issue 13, 2025, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo13070845

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Author(s): Azra Kulovic-Sissawo, Carolina Tocantins, Mariana S. Diniz, Elisa Weiss, Andreas Steiner, Silvija Tokic, Corina T. Madreiter-Sokolowski, Susana P. Pereira, Ursula Hiden
Published in: Biology, Issue 13, 2024, ISSN 2079-7737
Publisher: MDPI AG
DOI: 10.3390/biology13020070

Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review

Author(s): Agostino Di Ciaula, Mohamad Khalil, Gyorgy Baffy, Piero Portincasa
Published in: European Journal of Internal Medicine, Issue 128, 2024, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2024.07.008

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction

Author(s): Daniela Rosendo-Silva, Pedro Bastos Gomes, Tiago Rodrigues, Sofia Viana, Andr Nogueira da Costa, Philipp E. Scherer, Flvio Reis, Francisco Pereira, Raquel Seia, Paulo Matafome
Published in: Metabolism, Issue 153, 2024, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2024.155788

Hepatic glucose metabolism in the steatotic liver

Author(s): Egeria Scoditti, Silvia Sabatini, Fabrizia Carli, Amalia Gastaldelli
Published in: Nature Reviews Gastroenterology &amp; Hepatology, Issue 21, 2024, ISSN 1759-5045
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41575-023-00888-8

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Author(s): LusF. Grilo, JooD. Martins, MarianaS. Diniz, Carolina Tocantins, ChiaraH. Cavallaro, Ins Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, PeterW. Nathanielsz, PauloJ. Oliveira, SusanaP. Pereira
Published in: Clinical Science, Issue 137, 2023, ISSN 0143-5221
Publisher: Portland Press Ltd.
DOI: 10.1042/CS20230048

Mitochondrial DNA – novel mechanisms of kidney damage and potential biomarker

Author(s): Afshan N. Malik
Published in: Current Opinion in Nephrology &amp; Hypertension, Issue 32, 2024, ISSN 1062-4821
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/mnh.0000000000000922

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Author(s): Diana Sousa, CarinaC. Magalhes, Paulo Matafome, SusanaP. Pereira
Published in: Bioscience Reports, Issue 44, 2024, ISSN 0144-8463
Publisher: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Co-regulation and synteny of GFM2 and NSA2 links ribosomal function in mitochondria and the cytosol with chronic kidney disease

Author(s): Minjie Zhang, Christer Hogstrand, Paola Pontrelli, Afshan N Malik
Published in: Molecular Medicine, Issue 30, 2024, ISSN 1528-3658
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s10020-024-00930-8

Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations

Author(s): Piero Portincasa, Agostino Di Ciaula, Leonilde Bonfrate, Alessandro Stella, Gabriella Garruti, John Thomas Lamont
Published in: Internal and Emergency Medicine, Issue 18, 2023, ISSN 1828-0447
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03355-z

Metabolic Dysfunction–Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options

Author(s): Piero Portincasa, Mohamad Khalil, Laura Mahdi, Valeria Perniola, Valeria Idone, Annarita Graziani, Gyorgy Baffy, Agostino Di Ciaula
Published in: International Journal of Molecular Sciences, Issue 25, 2024, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms25115640

Renal sinus adipose tissue: exploratory study of metabolic features and transcriptome compared with omental and subcutaneous adipose tissue

Author(s): Maria J. Pereira, Argyri Mathioudaki, Alicia G. Otero, Padma Priya Duvvuri, Milica Vranic, Amir Sedigh, Jan W. Eriksson, Maria K. Svensson
Published in: Obesity, Issue 32, 2024, ISSN 1930-7381
Publisher: Wiley
DOI: 10.1002/oby.24114

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Author(s): Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202309211

Corrigendum to “The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity” [Mol. Cell. Endocrinol. 594 (2024), 112367]

Author(s): Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Inês Falcão-Pires, Hans Eickhoff, Sofia Viana, Flávio Reis, Ana Salomé Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seiça, Paulo Matafome
Published in: Molecular and Cellular Endocrinology, Issue 595, 2024, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2024.112410

Distinct biophysiological effects of Ramadan fasting and traditional intermittent fasting on markers of body fat storage. A real-life study

Author(s): Mohamad Khalil, Hala Abdallah, Nour Jaber, Gabriella Garruti, Agostino Di Ciaula, Piero Portincasa
Published in: European Journal of Internal Medicine, Issue 129, 2024, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2024.08.014

Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy

Author(s): Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, David Rizo-Roca, Estela Santos-Alves, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1871, 2024, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2024.167539

The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity

Author(s): Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Ins Falco-Pires, Hans Eickhoff, Sofia Viana, Flvio Reis, Ana Salom Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seia, Paulo Matafome
Published in: Molecular and Cellular Endocrinology, Issue 594, 2024, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2024.112367

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Author(s): Fabrizia Carli, Giuseppe Della Pepa, Silvia Sabatini, Antonio Vidal Puig, Amalia Gastaldelli
Published in: JHEP Reports, Issue 6, 2024, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101185

Oxidative stress in metabolic dysfunctionassociated steatotic liver disease (<scp>MASLD</scp>): How does the animal model resemble human disease?

Author(s): Patrycja Jakubek, Piotr Kalinowski, Agnieszka KarkucinskaWieckowska, Aakruti Kaikini, Ins C. M. Simes, Yaiza Potes, Beata Kruk, Wieslawa Grajkowska, Paolo Pinton, Piotr Milkiewicz, Micha Grt, Maciej Pronicki, Magdalena LebiedzinskaArciszewska, Marcin Krawczyk, Mariusz R. Wieckowski
Published in: The FASEB Journal, Issue 38, 2024, ISSN 0892-6638
Publisher: Wiley
DOI: 10.1096/fj.202302447R

Multidimensional Assessment of Sarcopenia and Sarcopenic Obesity in Geriatric Patients: Creatinine/Cystatin C Ratio Performs Better than Sarcopenia Index

Author(s): Mohamad Khalil, Agostino Di Ciaula, Nour Jaber, Roberta Grandolfo, Flavia Fiermonte, Piero Portincasa
Published in: Metabolites, Issue 14, 2024, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo14060306

Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women

Author(s): Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J Pereira, Jan W Eriksson
Published in: Endocrinology, Issue 165, 2023, ISSN 1945-7170
Publisher: The Endocrine Society
DOI: 10.1210/endocr/bqad172

Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?

Author(s): Piero Portincasa, Mohamad Khalil, Annarita Graziani, Gema Frhbeck, Gyorgy Baffy, Gabriella Garruti, Agostino Di Ciaula, Leonilde Bonfrate
Published in: European Journal of Internal Medicine, Issue 119, 2024, ISSN 0953-6205
Publisher: Elsevier BV
DOI: 10.1016/j.ejim.2023.10.002

Metabolic mitochondrial alterations prevail in the female rat heart 8weeks after exercise cessation

Author(s): Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena StevanovicSilva, Jorge Beleza, Pedro Coxito, David RizoRoca, Estela SantosAlves, Manoel Rios, Lina Carvalho, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Published in: European Journal of Clinical Investigation, Issue 53, 2023, ISSN 0014-2972
Publisher: Wiley
DOI: 10.1111/eci.14069

Proteomic Profiling of Plasma- and Gut-Derived Extracellular Vesicles in Obesity

Author(s): Pedro Baptista Pereira, Estefania Torrejón, Inês Ferreira, Ana Sofia Carvalho, Akiko Teshima, Inês Sousa-Lima, Hans Christian Beck, Bruno Costa-Silva, Rune Matthiesen, Maria Paula Macedo, Rita Machado de Oliveira
Published in: Nutrients, Issue 16, 2024, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/nu16050736

Book chapters (1)

Absolute Quantification of Cellular and Cell-Free Mitochondrial DNA Copy Number from Human Blood and Urinary Samples Using Real Time Quantitative PCR

Author(s): Eliane Caseiro Soares de Menezes, Afshan Navid Malik
Published in: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2024
Publisher: Springer US
DOI: 10.1007/978-1-0716-4264-1_13