Fighting childhood obesity to stay healthy all over the life

Información del proyecto

OBELISK

Identificador del acuerdo de subvención: 101080465

DOI

10.3030/101080465

Fecha de la firma de la CE 7 Abril 2023

Fecha de inicio 1 Mayo 2023

Fecha de finalización 30 Abril 2028

Financiado con arreglo a

• Health

Coste total

€ 10 054 268,00

Aportación de la UE

€ 10 054 268,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

OBELISK website

Public facing website to engage with OBELISK target audiences.

Other (1)

SWOT matrix of ELSI regarding preventative and policy measures for childhood obesity

Literature and policy review of ELSI regarding preventative measures for childhood obesity and policy-based options which will deliver a SWOT matrix of results

Documents, reports (1)

OBELISK data catalogue

A publicly available catalogue (metadata) of European cohorts to organize data sharing across OBELISK and make the data FAIR across the other project in the cluster

Publicaciones

Peer reviewed articles (34)

Nature Communications

Autores: David Aranda-García; Tomasz Maciej Stepniewski; Mariona Torrens-Fontanals; Adrian García-Recio; Marta Lopez-Balastegui; Brian Medel-Lacruz; Adrián Morales-Pastor; Alejandro Peralta-García; Miguel Dieguez-Eceolaza; David Sotillo-Nuñez; Tianyi Ding; Matthäus Drabek; Célien Jacquemard; Jakub Jakowiecki; Willem Jespers; Mireia Jiménez-Rosés; Víctor Jun-Yu-Lim; Alessandro Nicoli; Urszula Orzel; Aida Shahraki; Johanna K. S. Tiemann; Vicente Ledesma-Martin; Francho Nerín-Fonz; Sergio Suárez-Dou; Oriol Canal; Gáspár Pándy-Szekeres; Jiafei Mao; David E. Gloriam; Esther Kellenberger; Dorota Latek; Ramon Guixà-González; Hugo Gutiérrez-de-Terán; Irina G. Tikhonova; Peter W. Hildebrand; Marta Filizola; M. Madan Babu; Antonella Di Pizio; Slawomir Filipek; Peter Kolb; Arnau Cordomi; Toni Giorgino; Maria Marti-Solano; Jana Selent
Publicado en: Nature Communications, 2025, ISSN 2041-1723
Editor: Springer Nature
DOI: 10.1038/S41467-025-57034-Y

Alternative splicing landscape in mouse skeletal muscle and adipose tissue: Effects of intermittent fasting and exercise

Autores: Jasmin Gaugel; Markus Jähnert; Alexander Neumann; Florian Heyd; Annette Schürmann; Heike Vogel
Publicado en: The Journal of Nutritional Biochemistry, 2025, ISSN 1873-4847
Editor: Elsevier Inc
DOI: 10.17169/REFUBIUM-46266

Abstracts from the 34th Annual European Childhood Obesity Group Congress

Autores: Leila Mathy
Publicado en: Annals of Nutrition and Metabolism, Edición 82, 2026, ISSN 0250-6807
Editor: S. Karger AG
DOI: 10.1159/000548970

Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity

Autores: Wenwen Gao; Lei Liu; Eunna Huh; Florence Gbahou; Erika Cecon; Masaya Oshima; Ludivine Houzé; Panagiotis Katsonis; Alan Hegron; Zhiran Fan; Guofei Hou; Guillaume Charpentier; Mathilde Boissel; Mehdi Derhourhi; Michel Marre; Beverley Balkau; Philippe Froguel; Raphael Scharfmann; Olivier Lichtarge; Julie Dam; Amélie Bonnefond; Jianfeng Liu; Ralf Jockers
Publicado en: Nature Metabolism, 2023, ISSN 2522-5812
Editor: Springer Nature
DOI: 10.1038/s42255-023-00889-6

Nutrients

Autores: Valeria Calcaterra; Hellas Cena; Federica Loperfido; Debora Porri; Sara Basilico; Cassandra Gazzola; Cecilia Ricciardi Rizzo; Maria Vittoria Conti; Giovanni Luppino; Malgorzata Gabriela Wasniewska; Gianvincenzo Zuccotti
Publicado en: Nutrients, 2024, ISSN 2072-6643
Editor: MDPI
DOI: 10.3390/NU17010123

Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy

Autores: Giovanni Luppino, Mara Giordano, Francesca Franchina, Roberto Coco, Eleonora Inì, Carla Fazio, Debora Porri, Cecilia Lugarà, Domenico Corica, Tommaso Aversa, Malgorzata Wasniewska
Publicado en: Current Edicións in Molecular Biology, Edición 48, 2026, ISSN 1467-3045
Editor: MDPI AG
DOI: 10.3390/CIMB48020162

Picalm, a novel regulator of GLUT4-trafficking in adipose tissue

Autores: Jasmin Gaugel, Neele Haacke, Ratika Sehgal, Markus Jähnert, Wenke Jonas, Anne Hoffmann, Matthias Blüher, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Joycelyn Tan, Annette Schürmann, Daniel J. Fazakerley, Heike Vogel
Publicado en: Molecular Metabolism, Edición 88, 2024, ISSN 2212-8778
Editor: Elsevier BV
DOI: 10.1016/j.molmet.2024.102014

Biallelic variants in SREK1 downregulating SNORD115 and SNORD116 cause a Prader-Willi–like syndrome

Autores: Sadia Saeed, Anna-Maria Siegert, Y.C. Loraine Tung, Roohia Khanam, Qasim M. Janjua, Jaida Manzoor, Mehdi Derhourhi, Bénédicte Toussaint, Brian Y.H. Lam, Sherine Awad Mahmoud, Emmanuel Vaillant, Emmanuel Buse Falay, Souhila Amanzougarene, Hina Ayesha, Waqas I. Khan, Nosheen Ramazan, Vladimir Saudek, Stephen O’Rahilly, Anthony P. Goldstone, Muhammad Arslan, Amélie Bonnefond, Philippe Froguel, Giles S.H. Yeo
Publicado en: Journal of Clinical Investigation, Edición 135, 2026, ISSN 1558-8238
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI191008

Picalm coordinates clathrin-mediated endocytosis and actin remodeling during myogenesis

Autores: Jasmin Gaugel, Neele Haacke, Benno Kuropka, Markus Jähnert, Julia Rominger, Wenke Jonas, Thilo Speckmann, Niclas Rausch, Maximilian Kleinert, Cora Weigert, Francisco Garcia-Carrizo, Tim J. Schulz, Michael Ebner, Christian Freund, Annette Schürmann, Heike Vogel
Publicado en: Molecular Metabolism, Edición 107, 2026, ISSN 2212-8778
Editor: Elsevier BV
DOI: 10.1016/J.MOLMET.2026.102351

Nature Communications

Autores: Adrian Morales-Pastor; Tamara Miljuš; Miguel Dieguez-Eceolaza; Tomasz Maciej Stępniewski; Vicente Ledesma-Martin; Franziska M. Heydenreich; Tilman Flock; Bianca Plouffe; Christian Le Gouill; Jean Duchaine; David A. Sykes; Colin Nicholson; Eline J. Koers; Wolfgang Guba; Arne C. Rufer; Uwe Grether; Michel Bouvier; Dmitry B. Veprintsev; Jana Selent
Publicado en: Nature Communications, 2025, ISSN 2041-1723
Editor: Springer Nature
DOI: 10.3929/ETHZ-B-000741378

The genetics of obesity: aetiology, prevention and therapy

Autores: Amélie Bonnefond, Winter S. Bruner, Struan F. A. Grant, Anita Morandi, Philippe Froguel
Publicado en: Nature Metabolism, Edición 8, 2026, ISSN 2522-5812
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S42255-026-01497-W

Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations

Autores: Roca-Rivada, Arturo; Do Cruzeiro, Marcio; Denis, Raphaël G.P.; Zhang, Qiang; Rouault, Christine; Rouillé, Yves; Launay, Jean-Marie; Cruciani-Guglielmacci, Céline; Mattot, Virginie; Clément, Karine; Jockers, Ralf; Dam, Julie
Publicado en: JCI Insight, 2024, ISSN 2379-3708
Editor: Ann Arbor Michigan: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.168418

Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood

Autores: Maguolo, Alice; Jönsson, Josefine; Perfilyev, Alexander; Vaag, Allan; Malchau Carlsen, Emma; Nørgaard, Kirsten; Franks, Paul W.; Renault, Kristina M.; Ling, Charlotte
Publicado en: Clinical Epigenetics, 2025, ISSN 1868-7083
Editor: Springer Nature
DOI: 10.1186/S13148-025-01923-Y

<scp>D</scp><scp>NA</scp> methylation in cord blood partially mediates the effects of prepregnancy <scp>BMI</scp> on early childhood offspring <scp>BMI</scp>

Autores: Alice Maguolo, Josefine Jönsson, Alexander Perfilyev, Marlena Maziarz, Allan Vaag, Emma Malchau Carlsen, Kirsten Nørgaard, Paul W. Franks, Kristina M. Renault, Charlotte Ling
Publicado en: Obesity, Edición 33, 2024, ISSN 1930-7381
Editor: Wiley
DOI: 10.1002/OBY.24174

Nutrients

Autores: Porri, Debora; Wasniewska, Malgorzata; Luppino, Giovanni; Morabito, Letteria Anna; La Rosa, Elisa; Pepe, Giorgia; Corica, Domenico; Valenzise, Mariella; Messina, Maria Francesca; Zirilli, Giuseppina; Li Pomi, Alessandra; Lanzafame, Aurora; Alibrandi, Angela; Aversa, Tommaso
Publicado en: Nutrients, 2025, ISSN 2072-6643
Editor: MDPI
DOI: 10.3390/NU17040650

Nutrients

Autores: Porri, Debora; La Rosa, Elisa; Pepe, Giorgia; Morabito, Letteria Anna; Arena, Valentina; Luppino, Giovanni; Fazio, Carla; Li Pomi, Alessandra; Corica, Domenico; Alibrandi, Angela; Di Mauro, Debora; Aversa, Tommaso; Wasniewska, Malgorzata
Publicado en: Nutrients, 2025, ISSN 2072-6643
Editor: MDPI
DOI: 10.3390/NU17132181

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI

Autores: Omar Baritello; Simon H. Sündermann; Kristian Espinosa‐Garnica; Jörg Kempfert; Markus Jähnert; Nick L. Beetz; Dominik Geisel; Jasmin Gaugel; Julia Rominger; Ursula Müller‐Werdan; Catrin Herpich; Kristina Norman; Alexandra Chadt; Hadi Al‐Hasani; Heinz Völler; Annett Salzwedel; Heike Vogel
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, 2025, ISSN 2190-6009
Editor: Wiley
DOI: 10.1002/JCSM.13846

Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction

Autores: Ratika Sehgal; Markus Jähnert; Michail Lazaratos; Thilo Speckmann; Fabian Schumacher; Burkhard Kleuser; Meriem Ouni; Wenke Jonas; Annette Schürmann
Publicado en: Journal of Lipid Research, 2025, ISSN 1539-7262
Editor: Elsevier Inc
DOI: 10.1016/J.JLR.2025.100767

Monoallelic pathogenic variants in LEPR do not cause obesity

Autores: Jérôme Delplanque, Lauriane Le Collen, Hélène Loiselle, Audrey Leloire, Bénédicte Toussaint, Emmanuel Vaillant, Guillaume Charpentier, Sylvia Franc, Beverley Balkau, Michel Marre, Emma Henriques, Emmanuel Buse Falay, Mehdi Derhourhi, Philippe Froguel, Amélie Bonnefond
Publicado en: The American Journal of Human Genetics, Edición 111, 2026, ISSN 0002-9297
Editor: Elsevier BV
DOI: 10.1016/J.AJHG.2024.10.014

Melatonin receptor structure and signaling

Autores: Okamoto, Hiroyuki; Cecon, Erika; Nureki, Osamu; Rivara, Silvia; Jockers, Ralf
Publicado en: Journal of Pineal Research, 2024, ISSN 1600-079X
Editor: Wiley
DOI: 10.1111/JPI.12952

A framework for conducting GWAS using repeated measures data with an application to childhood BMI

Autores: Burrows, Kimberley; Heiskala, Anni; Bradfield, Jonathan P; Balkhiyarova, Zhanna; Ning, Lijiao; Boissel, Mathilde; Chan, Yee-Ming; Froguel, Philippe; Bonnefond, Amelie; Hakonarson, Hakon; Alves, Alexessander Couto; Lawlor, Deborah A; Kaakinen, Marika; Järv
Publicado en: Nature communications , ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/S41467-024-53687-3

Building a Healthy Future: Functional Motor Skill Development in Precocious Prevention of Childhood Obesity

Autores: Porri, Debora; Wasniewska, Malgorzata; Luppino, Giovanni; Morabito, Letteria Anna; La Rosa, Elisa; Pepe, Giorgia; Corica, Domenico; Valenzise, Mariella; Messina, Maria Francesca; Zirilli, Giuseppina; Li Pomi, Alessandra; Lanzafame, Aurora; Arena, Valentina; Alibrandi, Angela; Di Mauro, Debora; Aversa, Tommaso
Publicado en: Journal of Functional Morphology and Kinesiology, 2025, ISSN 2411-5142
Editor: MDPI
DOI: 10.3390/JFMK10020186

Alternative splicing landscape in mouse skeletal muscle and adipose tissue: Effects of intermittent fasting and exercise

Autores: Jasmin Gaugel, Markus Jähnert, Alexander Neumann, Florian Heyd, Annette Schürmann, Heike Vogel
Publicado en: The Journal of Nutritional Biochemistry, Edición 137, 2025, ISSN 0955-2863
Editor: Elsevier BV
DOI: 10.1016/J.JNUTBIO.2024.109837

Pathogenic, Total Loss-of-Function <i>DYRK1B</i> Variants Cause Monogenic Obesity Associated With Type 2 Diabetes

Autores: Lise Folon, Morgane Baron, Victoria Scherrer, Bénédicte Toussaint, Emmanuel Vaillant, Hélène Loiselle, Aurélie Dechaume, Frédérique De Pooter, Raphaël Boutry, Mathilde Boissel, Aboubacar Diallo, Lijiao Ning, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Michel Marre, Mehdi Derhourhi, Philippe Froguel, Amélie Bonnefond
Publicado en: Diabetes Care, Edición 47, 2024, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/DC23-1851

<i>PNLIPRP1</i> Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism

Autores: Lucas Maurin, Lorella Marselli, Mathilde Boissel, Lijiao Ning, Raphael Boutry, Justine Fernandes, Mara Suleiman, Carmela De Luca, Audrey Leloire, Vincent Pascat, Bénédicte Toussaint, Souhila Amanzougarene, Mehdi Derhourhi, Anne Jörns, Sigurd Lenzen, François Pattou, Julie Kerr-Conte, Mickaël Canouil, Piero Marchetti, Amélie Bonnefond, Philippe Froguel, Amna Khamis
Publicado en: Diabetes, Edición 73, 2024, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/DB24-0215

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

Autores: Marta Lopez‐Balastegui; Tomasz Maciej Stepniewski; Małgorzata M. Kogut‐Günthel; Antonella Di Pizio; Mette Marie Rosenkilde; Jiafei Mao; Jana Selent
Publicado en: British Journal of Pharmacology, 2024, ISSN 1476-5381
Editor: Wiley
DOI: 10.1111/BPH.16495

The Influence of Ultra-Processed Foods on Inflammation and Metabolic Health in Pediatric Obesity: A Systematic Review with a Narrative Synthesis

Autores: Debora Porri, Malgorzata Wasniewska, Alessandra Li Pomi, Elisa La Rosa, Giovanni Luppino, Aurora Lanzafame, Cecilia Lugarà, Roberto Coco, Francesca Franchina, Tiziana Abbate, Carla Fazio, Valentina La Malfa, Letteria Anna Morabito, Giorgia Pepe, Mariella Valenzise, Maria Francesca Messina, Domenico Corica, Tommaso Aversa
Publicado en: Nutrients, Edición 18, 2026, ISSN 2072-6643
Editor: MDPI AG
DOI: 10.3390/NU18081186

Variant reclassification over time decreases the level of diagnostic uncertainty in monogenic obesity: Experience from two centres

Autores: Anita Morandi, Elena Fornari, Massimiliano Corradi, Giuseppina Rosaria Umano, Francesca Olivieri, Claudia Piona, Alice Maguolo, Carola Panzeri, Federica Emiliani, Grazia Cirillo, Paolo Cavarzere, Emanuele Miraglia Del Giudice, Claudio Maffeis
Publicado en: Pediatric Obesity, Edición 19, 2024, ISSN 2047-6302
Editor: Wiley
DOI: 10.1111/ijpo.13183

Rare <i>ZMPSTE24</i> variants increase risk of hypertriglyceridemia and metabolic syndrome

Autores: Lauriane Le Collen, Camille Desgrouas, Céline Lukas Croisier, Brunot Creugnet, Aurélie Dechaume, Bénédicte Toussaint, Emmanuel Vaillant, Souhila Amanzougarene, Emmanuel Buse Falay, Mehdi Derhourhi, Alexandre Lourdelle, Brigitte Delemer, Nathalie Bonello-Palot, Martine Vaxillaire, Catherine Badens, Philippe Froguel, Amélie Bonnefond
Publicado en: European Journal of Endocrinology, Edición 192, 2025, ISSN 0804-4643
Editor: Oxford University Press (OUP)
DOI: 10.1093/EJENDO/LVAF031

Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes

Autores: Leona Kovac, Sofiya Gancheva, Markus Jähnert, Ratika Sehgal, Lucia Mastrototaro, Matthias Schlensak, Frank A. Granderath, Kilian Rittig, Michael Roden, Annette Schürmann, Sabine Kahl, Meriem Ouni
Publicado en: Diabetes &amp; Metabolism, Edición 50, 2024, ISSN 1262-3636
Editor: Elsevier BV
DOI: 10.1016/j.diabet.2024.101561

Dominant PDX1 deficiency causes highly penetrant diabetes at different ages, associated with obesity and exocrine pancreatic deficiency: Lessons for precision medicine

Autores: Youssef Kouidrat, Lauriane Le Collen, Martine Vaxillaire, Aurélie Dechaume, Bénédicte Toussaint, Emmanuel Vaillant, Souhila Amanzougarene, Mehdi Derhourhi, Brigitte Delemer, Mustapha Azahaf, Philippe Froguel, Amélie Bonnefond
Publicado en: Diabetes &amp; Metabolism, Edición 50, 2024, ISSN 1262-3636
Editor: Elsevier BV
DOI: 10.1016/J.DIABET.2023.101507

BMC Medicine

Autores: Sehgal, Ratika; Haacke, Neele; Maguolo, Alice; Solari, Fiorella A.; Jähnert, Markus; Gottmann, Pascal; Nilsson, Emma; Vaag, Allan; Fischer-Posovszky, Pamela; Werberger, Anja; Birkenfeld, Andreas L.; Fritsche, Andreas; Häring, Hans-Ulrich; Sickmann, Albert; Vogel, Heike; Ling, Charlotte; Ouni, Meriem; Schürmann, Annette
Publicado en: BMC Medicine, 2025, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/S12916-025-04560-7

Embedded Ethics in Practice: A Toolbox for Integrating the Analysis of Ethical and Social Issues into Healthcare AI Research

Autores: Theresa Willem; Marie-Christine Fritzsche; Bettina M. Zimmermann; Anna Sierawska; Svenja Breuer; Maximilian Braun; Anja K. Ruess; Marieke Bak; Franziska B. Schönweitz; Lukas J. Meier; Amelia Fiske; Daniel Tigard; Ruth Müller; Stuart McLennan; Alena Buyx
Publicado en: Science and Engineering Ethics, 2024, ISSN 1471-5546
Editor: Springer Nature
DOI: 10.48620/84604

AlloViz: A tool for the calculation and visualisation of protein allosteric communication networks

Autores: Francho Nerín-Fonz; Camilla Caprai; Adrián Morales-Pastor; Marta Lopez-Balastegui; David Aranda-García; Toni Giorgino; Jana Selent
Publicado en: Computational and Structural Biotechnology Journal, 2024, ISSN 2001-0370
Editor: Göteborg: Chalmers University of Technology
DOI: 10.1016/J.CSBJ.2024.04.047