Fighting childhood obesity to stay healthy all over the life

Informazioni relative al progetto

OBELISK

ID dell’accordo di sovvenzione: 101080465

DOI

10.3030/101080465

Data della firma CE 7 Aprile 2023

Data di avvio 1 Maggio 2023

Data di completamento 30 Aprile 2028

Finanziato da

• Health

Costo totale

€ 10 054 268,00

Contributo UE

€ 10 054 268,00

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

OBELISK website

Public facing website to engage with OBELISK target audiences.

Other (1)

SWOT matrix of ELSI regarding preventative and policy measures for childhood obesity

Literature and policy review of ELSI regarding preventative measures for childhood obesity and policy-based options which will deliver a SWOT matrix of results

Documents, reports (1)

OBELISK data catalogue

A publicly available catalogue (metadata) of European cohorts to organize data sharing across OBELISK and make the data FAIR across the other project in the cluster

Pubblicazioni

Peer reviewed articles (34)

Nature Communications

Autori: David Aranda-García; Tomasz Maciej Stepniewski; Mariona Torrens-Fontanals; Adrian García-Recio; Marta Lopez-Balastegui; Brian Medel-Lacruz; Adrián Morales-Pastor; Alejandro Peralta-García; Miguel Dieguez-Eceolaza; David Sotillo-Nuñez; Tianyi Ding; Matthäus Drabek; Célien Jacquemard; Jakub Jakowiecki; Willem Jespers; Mireia Jiménez-Rosés; Víctor Jun-Yu-Lim; Alessandro Nicoli; Urszula Orzel; Aida Shahraki; Johanna K. S. Tiemann; Vicente Ledesma-Martin; Francho Nerín-Fonz; Sergio Suárez-Dou; Oriol Canal; Gáspár Pándy-Szekeres; Jiafei Mao; David E. Gloriam; Esther Kellenberger; Dorota Latek; Ramon Guixà-González; Hugo Gutiérrez-de-Terán; Irina G. Tikhonova; Peter W. Hildebrand; Marta Filizola; M. Madan Babu; Antonella Di Pizio; Slawomir Filipek; Peter Kolb; Arnau Cordomi; Toni Giorgino; Maria Marti-Solano; Jana Selent
Pubblicato in: Nature Communications, 2025, ISSN 2041-1723
Editore: Springer Nature
DOI: 10.1038/S41467-025-57034-Y

Alternative splicing landscape in mouse skeletal muscle and adipose tissue: Effects of intermittent fasting and exercise

Autori: Jasmin Gaugel; Markus Jähnert; Alexander Neumann; Florian Heyd; Annette Schürmann; Heike Vogel
Pubblicato in: The Journal of Nutritional Biochemistry, 2025, ISSN 1873-4847
Editore: Elsevier Inc
DOI: 10.17169/REFUBIUM-46266

Abstracts from the 34th Annual European Childhood Obesity Group Congress

Autori: Leila Mathy
Pubblicato in: Annals of Nutrition and Metabolism, Numero 82, 2026, ISSN 0250-6807
Editore: S. Karger AG
DOI: 10.1159/000548970

Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity

Autori: Wenwen Gao; Lei Liu; Eunna Huh; Florence Gbahou; Erika Cecon; Masaya Oshima; Ludivine Houzé; Panagiotis Katsonis; Alan Hegron; Zhiran Fan; Guofei Hou; Guillaume Charpentier; Mathilde Boissel; Mehdi Derhourhi; Michel Marre; Beverley Balkau; Philippe Froguel; Raphael Scharfmann; Olivier Lichtarge; Julie Dam; Amélie Bonnefond; Jianfeng Liu; Ralf Jockers
Pubblicato in: Nature Metabolism, 2023, ISSN 2522-5812
Editore: Springer Nature
DOI: 10.1038/s42255-023-00889-6

Nutrients

Autori: Valeria Calcaterra; Hellas Cena; Federica Loperfido; Debora Porri; Sara Basilico; Cassandra Gazzola; Cecilia Ricciardi Rizzo; Maria Vittoria Conti; Giovanni Luppino; Malgorzata Gabriela Wasniewska; Gianvincenzo Zuccotti
Pubblicato in: Nutrients, 2024, ISSN 2072-6643
Editore: MDPI
DOI: 10.3390/NU17010123

Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy

Autori: Giovanni Luppino, Mara Giordano, Francesca Franchina, Roberto Coco, Eleonora Inì, Carla Fazio, Debora Porri, Cecilia Lugarà, Domenico Corica, Tommaso Aversa, Malgorzata Wasniewska
Pubblicato in: Current Numeros in Molecular Biology, Numero 48, 2026, ISSN 1467-3045
Editore: MDPI AG
DOI: 10.3390/CIMB48020162

Picalm, a novel regulator of GLUT4-trafficking in adipose tissue

Autori: Jasmin Gaugel, Neele Haacke, Ratika Sehgal, Markus Jähnert, Wenke Jonas, Anne Hoffmann, Matthias Blüher, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Joycelyn Tan, Annette Schürmann, Daniel J. Fazakerley, Heike Vogel
Pubblicato in: Molecular Metabolism, Numero 88, 2024, ISSN 2212-8778
Editore: Elsevier BV
DOI: 10.1016/j.molmet.2024.102014

Biallelic variants in SREK1 downregulating SNORD115 and SNORD116 cause a Prader-Willi–like syndrome

Autori: Sadia Saeed, Anna-Maria Siegert, Y.C. Loraine Tung, Roohia Khanam, Qasim M. Janjua, Jaida Manzoor, Mehdi Derhourhi, Bénédicte Toussaint, Brian Y.H. Lam, Sherine Awad Mahmoud, Emmanuel Vaillant, Emmanuel Buse Falay, Souhila Amanzougarene, Hina Ayesha, Waqas I. Khan, Nosheen Ramazan, Vladimir Saudek, Stephen O’Rahilly, Anthony P. Goldstone, Muhammad Arslan, Amélie Bonnefond, Philippe Froguel, Giles S.H. Yeo
Pubblicato in: Journal of Clinical Investigation, Numero 135, 2026, ISSN 1558-8238
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI191008

Picalm coordinates clathrin-mediated endocytosis and actin remodeling during myogenesis

Autori: Jasmin Gaugel, Neele Haacke, Benno Kuropka, Markus Jähnert, Julia Rominger, Wenke Jonas, Thilo Speckmann, Niclas Rausch, Maximilian Kleinert, Cora Weigert, Francisco Garcia-Carrizo, Tim J. Schulz, Michael Ebner, Christian Freund, Annette Schürmann, Heike Vogel
Pubblicato in: Molecular Metabolism, Numero 107, 2026, ISSN 2212-8778
Editore: Elsevier BV
DOI: 10.1016/J.MOLMET.2026.102351

Nature Communications

Autori: Adrian Morales-Pastor; Tamara Miljuš; Miguel Dieguez-Eceolaza; Tomasz Maciej Stępniewski; Vicente Ledesma-Martin; Franziska M. Heydenreich; Tilman Flock; Bianca Plouffe; Christian Le Gouill; Jean Duchaine; David A. Sykes; Colin Nicholson; Eline J. Koers; Wolfgang Guba; Arne C. Rufer; Uwe Grether; Michel Bouvier; Dmitry B. Veprintsev; Jana Selent
Pubblicato in: Nature Communications, 2025, ISSN 2041-1723
Editore: Springer Nature
DOI: 10.3929/ETHZ-B-000741378

The genetics of obesity: aetiology, prevention and therapy

Autori: Amélie Bonnefond, Winter S. Bruner, Struan F. A. Grant, Anita Morandi, Philippe Froguel
Pubblicato in: Nature Metabolism, Numero 8, 2026, ISSN 2522-5812
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S42255-026-01497-W

Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations

Autori: Roca-Rivada, Arturo; Do Cruzeiro, Marcio; Denis, Raphaël G.P.; Zhang, Qiang; Rouault, Christine; Rouillé, Yves; Launay, Jean-Marie; Cruciani-Guglielmacci, Céline; Mattot, Virginie; Clément, Karine; Jockers, Ralf; Dam, Julie
Pubblicato in: JCI Insight, 2024, ISSN 2379-3708
Editore: Ann Arbor Michigan: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.168418

Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood

Autori: Maguolo, Alice; Jönsson, Josefine; Perfilyev, Alexander; Vaag, Allan; Malchau Carlsen, Emma; Nørgaard, Kirsten; Franks, Paul W.; Renault, Kristina M.; Ling, Charlotte
Pubblicato in: Clinical Epigenetics, 2025, ISSN 1868-7083
Editore: Springer Nature
DOI: 10.1186/S13148-025-01923-Y

<scp>D</scp><scp>NA</scp> methylation in cord blood partially mediates the effects of prepregnancy <scp>BMI</scp> on early childhood offspring <scp>BMI</scp>

Autori: Alice Maguolo, Josefine Jönsson, Alexander Perfilyev, Marlena Maziarz, Allan Vaag, Emma Malchau Carlsen, Kirsten Nørgaard, Paul W. Franks, Kristina M. Renault, Charlotte Ling
Pubblicato in: Obesity, Numero 33, 2024, ISSN 1930-7381
Editore: Wiley
DOI: 10.1002/OBY.24174

Nutrients

Autori: Porri, Debora; Wasniewska, Malgorzata; Luppino, Giovanni; Morabito, Letteria Anna; La Rosa, Elisa; Pepe, Giorgia; Corica, Domenico; Valenzise, Mariella; Messina, Maria Francesca; Zirilli, Giuseppina; Li Pomi, Alessandra; Lanzafame, Aurora; Alibrandi, Angela; Aversa, Tommaso
Pubblicato in: Nutrients, 2025, ISSN 2072-6643
Editore: MDPI
DOI: 10.3390/NU17040650

Nutrients

Autori: Porri, Debora; La Rosa, Elisa; Pepe, Giorgia; Morabito, Letteria Anna; Arena, Valentina; Luppino, Giovanni; Fazio, Carla; Li Pomi, Alessandra; Corica, Domenico; Alibrandi, Angela; Di Mauro, Debora; Aversa, Tommaso; Wasniewska, Malgorzata
Pubblicato in: Nutrients, 2025, ISSN 2072-6643
Editore: MDPI
DOI: 10.3390/NU17132181

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI

Autori: Omar Baritello; Simon H. Sündermann; Kristian Espinosa‐Garnica; Jörg Kempfert; Markus Jähnert; Nick L. Beetz; Dominik Geisel; Jasmin Gaugel; Julia Rominger; Ursula Müller‐Werdan; Catrin Herpich; Kristina Norman; Alexandra Chadt; Hadi Al‐Hasani; Heinz Völler; Annett Salzwedel; Heike Vogel
Pubblicato in: Journal of Cachexia, Sarcopenia and Muscle, 2025, ISSN 2190-6009
Editore: Wiley
DOI: 10.1002/JCSM.13846

Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction

Autori: Ratika Sehgal; Markus Jähnert; Michail Lazaratos; Thilo Speckmann; Fabian Schumacher; Burkhard Kleuser; Meriem Ouni; Wenke Jonas; Annette Schürmann
Pubblicato in: Journal of Lipid Research, 2025, ISSN 1539-7262
Editore: Elsevier Inc
DOI: 10.1016/J.JLR.2025.100767

Monoallelic pathogenic variants in LEPR do not cause obesity

Autori: Jérôme Delplanque, Lauriane Le Collen, Hélène Loiselle, Audrey Leloire, Bénédicte Toussaint, Emmanuel Vaillant, Guillaume Charpentier, Sylvia Franc, Beverley Balkau, Michel Marre, Emma Henriques, Emmanuel Buse Falay, Mehdi Derhourhi, Philippe Froguel, Amélie Bonnefond
Pubblicato in: The American Journal of Human Genetics, Numero 111, 2026, ISSN 0002-9297
Editore: Elsevier BV
DOI: 10.1016/J.AJHG.2024.10.014

Melatonin receptor structure and signaling

Autori: Okamoto, Hiroyuki; Cecon, Erika; Nureki, Osamu; Rivara, Silvia; Jockers, Ralf
Pubblicato in: Journal of Pineal Research, 2024, ISSN 1600-079X
Editore: Wiley
DOI: 10.1111/JPI.12952

A framework for conducting GWAS using repeated measures data with an application to childhood BMI

Autori: Burrows, Kimberley; Heiskala, Anni; Bradfield, Jonathan P; Balkhiyarova, Zhanna; Ning, Lijiao; Boissel, Mathilde; Chan, Yee-Ming; Froguel, Philippe; Bonnefond, Amelie; Hakonarson, Hakon; Alves, Alexessander Couto; Lawlor, Deborah A; Kaakinen, Marika; Järv
Pubblicato in: Nature communications , ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/S41467-024-53687-3

Building a Healthy Future: Functional Motor Skill Development in Precocious Prevention of Childhood Obesity

Autori: Porri, Debora; Wasniewska, Malgorzata; Luppino, Giovanni; Morabito, Letteria Anna; La Rosa, Elisa; Pepe, Giorgia; Corica, Domenico; Valenzise, Mariella; Messina, Maria Francesca; Zirilli, Giuseppina; Li Pomi, Alessandra; Lanzafame, Aurora; Arena, Valentina; Alibrandi, Angela; Di Mauro, Debora; Aversa, Tommaso
Pubblicato in: Journal of Functional Morphology and Kinesiology, 2025, ISSN 2411-5142
Editore: MDPI
DOI: 10.3390/JFMK10020186

Alternative splicing landscape in mouse skeletal muscle and adipose tissue: Effects of intermittent fasting and exercise

Autori: Jasmin Gaugel, Markus Jähnert, Alexander Neumann, Florian Heyd, Annette Schürmann, Heike Vogel
Pubblicato in: The Journal of Nutritional Biochemistry, Numero 137, 2025, ISSN 0955-2863
Editore: Elsevier BV
DOI: 10.1016/J.JNUTBIO.2024.109837

Pathogenic, Total Loss-of-Function <i>DYRK1B</i> Variants Cause Monogenic Obesity Associated With Type 2 Diabetes

Autori: Lise Folon, Morgane Baron, Victoria Scherrer, Bénédicte Toussaint, Emmanuel Vaillant, Hélène Loiselle, Aurélie Dechaume, Frédérique De Pooter, Raphaël Boutry, Mathilde Boissel, Aboubacar Diallo, Lijiao Ning, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Michel Marre, Mehdi Derhourhi, Philippe Froguel, Amélie Bonnefond
Pubblicato in: Diabetes Care, Numero 47, 2024, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/DC23-1851

<i>PNLIPRP1</i> Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism

Autori: Lucas Maurin, Lorella Marselli, Mathilde Boissel, Lijiao Ning, Raphael Boutry, Justine Fernandes, Mara Suleiman, Carmela De Luca, Audrey Leloire, Vincent Pascat, Bénédicte Toussaint, Souhila Amanzougarene, Mehdi Derhourhi, Anne Jörns, Sigurd Lenzen, François Pattou, Julie Kerr-Conte, Mickaël Canouil, Piero Marchetti, Amélie Bonnefond, Philippe Froguel, Amna Khamis
Pubblicato in: Diabetes, Numero 73, 2024, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/DB24-0215

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

Autori: Marta Lopez‐Balastegui; Tomasz Maciej Stepniewski; Małgorzata M. Kogut‐Günthel; Antonella Di Pizio; Mette Marie Rosenkilde; Jiafei Mao; Jana Selent
Pubblicato in: British Journal of Pharmacology, 2024, ISSN 1476-5381
Editore: Wiley
DOI: 10.1111/BPH.16495

The Influence of Ultra-Processed Foods on Inflammation and Metabolic Health in Pediatric Obesity: A Systematic Review with a Narrative Synthesis

Autori: Debora Porri, Malgorzata Wasniewska, Alessandra Li Pomi, Elisa La Rosa, Giovanni Luppino, Aurora Lanzafame, Cecilia Lugarà, Roberto Coco, Francesca Franchina, Tiziana Abbate, Carla Fazio, Valentina La Malfa, Letteria Anna Morabito, Giorgia Pepe, Mariella Valenzise, Maria Francesca Messina, Domenico Corica, Tommaso Aversa
Pubblicato in: Nutrients, Numero 18, 2026, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/NU18081186

Variant reclassification over time decreases the level of diagnostic uncertainty in monogenic obesity: Experience from two centres

Autori: Anita Morandi, Elena Fornari, Massimiliano Corradi, Giuseppina Rosaria Umano, Francesca Olivieri, Claudia Piona, Alice Maguolo, Carola Panzeri, Federica Emiliani, Grazia Cirillo, Paolo Cavarzere, Emanuele Miraglia Del Giudice, Claudio Maffeis
Pubblicato in: Pediatric Obesity, Numero 19, 2024, ISSN 2047-6302
Editore: Wiley
DOI: 10.1111/ijpo.13183

Rare <i>ZMPSTE24</i> variants increase risk of hypertriglyceridemia and metabolic syndrome

Autori: Lauriane Le Collen, Camille Desgrouas, Céline Lukas Croisier, Brunot Creugnet, Aurélie Dechaume, Bénédicte Toussaint, Emmanuel Vaillant, Souhila Amanzougarene, Emmanuel Buse Falay, Mehdi Derhourhi, Alexandre Lourdelle, Brigitte Delemer, Nathalie Bonello-Palot, Martine Vaxillaire, Catherine Badens, Philippe Froguel, Amélie Bonnefond
Pubblicato in: European Journal of Endocrinology, Numero 192, 2025, ISSN 0804-4643
Editore: Oxford University Press (OUP)
DOI: 10.1093/EJENDO/LVAF031

Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes

Autori: Leona Kovac, Sofiya Gancheva, Markus Jähnert, Ratika Sehgal, Lucia Mastrototaro, Matthias Schlensak, Frank A. Granderath, Kilian Rittig, Michael Roden, Annette Schürmann, Sabine Kahl, Meriem Ouni
Pubblicato in: Diabetes &amp; Metabolism, Numero 50, 2024, ISSN 1262-3636
Editore: Elsevier BV
DOI: 10.1016/j.diabet.2024.101561

Dominant PDX1 deficiency causes highly penetrant diabetes at different ages, associated with obesity and exocrine pancreatic deficiency: Lessons for precision medicine

Autori: Youssef Kouidrat, Lauriane Le Collen, Martine Vaxillaire, Aurélie Dechaume, Bénédicte Toussaint, Emmanuel Vaillant, Souhila Amanzougarene, Mehdi Derhourhi, Brigitte Delemer, Mustapha Azahaf, Philippe Froguel, Amélie Bonnefond
Pubblicato in: Diabetes &amp; Metabolism, Numero 50, 2024, ISSN 1262-3636
Editore: Elsevier BV
DOI: 10.1016/J.DIABET.2023.101507

BMC Medicine

Autori: Sehgal, Ratika; Haacke, Neele; Maguolo, Alice; Solari, Fiorella A.; Jähnert, Markus; Gottmann, Pascal; Nilsson, Emma; Vaag, Allan; Fischer-Posovszky, Pamela; Werberger, Anja; Birkenfeld, Andreas L.; Fritsche, Andreas; Häring, Hans-Ulrich; Sickmann, Albert; Vogel, Heike; Ling, Charlotte; Ouni, Meriem; Schürmann, Annette
Pubblicato in: BMC Medicine, 2025, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/S12916-025-04560-7

Embedded Ethics in Practice: A Toolbox for Integrating the Analysis of Ethical and Social Issues into Healthcare AI Research

Autori: Theresa Willem; Marie-Christine Fritzsche; Bettina M. Zimmermann; Anna Sierawska; Svenja Breuer; Maximilian Braun; Anja K. Ruess; Marieke Bak; Franziska B. Schönweitz; Lukas J. Meier; Amelia Fiske; Daniel Tigard; Ruth Müller; Stuart McLennan; Alena Buyx
Pubblicato in: Science and Engineering Ethics, 2024, ISSN 1471-5546
Editore: Springer Nature
DOI: 10.48620/84604

AlloViz: A tool for the calculation and visualisation of protein allosteric communication networks

Autori: Francho Nerín-Fonz; Camilla Caprai; Adrián Morales-Pastor; Marta Lopez-Balastegui; David Aranda-García; Toni Giorgino; Jana Selent
Pubblicato in: Computational and Structural Biotechnology Journal, 2024, ISSN 2001-0370
Editore: Göteborg: Chalmers University of Technology
DOI: 10.1016/J.CSBJ.2024.04.047