Validation of novel immunotherapeutic targets against fibrosis in inflammatory bowel diseases

Información del proyecto

FIBROTARGET

Identificador del acuerdo de subvención: 101080523

DOI

10.3030/101080523

Fecha de la firma de la CE 24 Abril 2023

Fecha de inicio 1 Abril 2023

Fecha de finalización 31 Marzo 2028

Financiado con arreglo a

• Health

Coste total

€ 5 686 450,00

Aportación de la UE

€ 5 686 450,00

Coordinado por

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Periodic Reporting for period 1 - FIBROTARGET (Validation of novel immunotherapeutic targets against fibrosis in inflammatory bowel diseases)

Período documentado: 2023-04-01 hasta 2024-09-30

Resumen del contexto y de los objetivos generales del proyecto

The FIBROTARGET project aims to transform the therapeutic landscape for intestinal fibrosis in inflammatory bowel diseases (IBD), particularly Crohn's disease (CD). Intestinal fibrosis, often leading to strictures, significantly impacts patients' quality of life and remains an unmet clinical need due to the lack of effective anti-fibrotic therapies. FIBROTARGET addresses this challenge through a multidisciplinary approach to understand fibrosis mechanisms, identify biomarkers, and develop innovative diagnostic tools and treatments.

Key objectives include:

Identifying and validating fibrosis-associated molecular signatures using advanced techniques such as single-cell RNA sequencing and spatial transcriptomics.

Preclinical evaluation of inhibitors targeting pathways like C3, Tyk2-STAT3, and NLRP3 inflammasomes in patient-derived tissues and experimental models.

Development of non-invasive imaging tools such as magnetic resonance enterography (MRE) integrated with artificial intelligence for fibrosis diagnosis and monitoring.

Designing and conducting the first-in-human trials of novel immunotherapeutics for fibrosis in CD.

Ensuring broad dissemination, patient engagement, and a sustainability plan for real-world impact.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

In its first reporting period, FIBROTARGET has:

Identified pathogenic fibroblast subsets and validated potential fibrosis biomarkers in IBD samples.

Demonstrated anti-inflammatory and anti-fibrotic effects of key inhibitors in preclinical models, showing promise for translation into clinical settings.

Advanced imaging techniques (MRE and MSOT) with AI integration for fibrosis detection, streamlining patient diagnostics and clinical trial design.

Engaged with regulatory bodies, industry partners, and patient organizations, ensuring alignment of project outputs with clinical and societal needs.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

FIBROTARGET has:

Uncovered the role of the NLRP3 inflammasome in fibroblast activation and collagen production, offering new therapeutic avenues.

Validated fibrosis-associated markers through high-resolution spatial transcriptomics and proteomics, paving the way for precision diagnostics.

Integrated imaging and AI technologies for reproducible, non-invasive assessment of fibrosis, setting a benchmark for future diagnostics.

Explored the potential of complement inhibitors like Cp40 to disrupt profibrotic pathways in human and experimental models.