Validation of novel immunotherapeutic targets against fibrosis in inflammatory bowel diseases

Información del proyecto

FIBROTARGET

Identificador del acuerdo de subvención: 101080523

DOI

10.3030/101080523

Fecha de la firma de la CE 24 Abril 2023

Fecha de inicio 1 Abril 2023

Fecha de finalización 31 Marzo 2028

Financiado con arreglo a

• Health

Coste total

€ 5 686 450,00

Aportación de la UE

€ 5 686 450,00

Coordinado por

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

MSOT for prognosis and diagnosis of intestinal fibrosis

Report on the results of the MSOT methods

AI solution for prognosis and diagnosis of intestinal fibrosis

Report on development of AI solution for prognosis and diagnosis model on structuring CD

Plan for the dissemination and exploitation including communication activities

Communication and Dissemination strategy, initial tactical plan & tools and strategy to build the sustainability plans

Websites, patent fillings, videos etc. (1)

Project website

Project public website available.

Publicaciones

Peer reviewed articles (9)

Fibroblast Heterogeneity in Inflammatory Bowel Disease

Autores: Bo-Jun Ke, Gabriele Dragoni, Gianluca Matteoli
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS252313008

Biomarkers for Personalizing IBD Therapy: The Quest Continues

Autores: Raja Atreya, Markus F. Neurath
Publicado en: Clinical Gastroenterology and Hepatology, Edición 22, 2024, ISSN 1542-3565
Editor: Elsevier BV
DOI: 10.1016/j.cgh.2024.01.026

Effect of Mutant and Engineered High-Acetate-Producing Saccharomyces cerevisiae var. boulardii Strains in Dextran Sodium Sulphate-Induced Colitis

Autores: Sara Deleu, Inge Jacobs, Jorge F. Vazquez Castellanos, Sare Verstockt, Bruna Trindade de Carvalho, Ana Subotić, Bram Verstockt, Kaline Arnauts, Lowie Deprez, Eva Vissers, Matthias Lenfant, Greet Vandermeulen, Gert De Hertogh, Kristin Verbeke, Gianluca Matteoli, Geert R. B. Huys, Johan M. Thevelein, Jeroen Raes, Séverine Vermeire
Publicado en: Nutrients, Edición 16, 2024, ISSN 2072-6643
Editor: MDPI AG
DOI: 10.3390/NU16162668

Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications

Autores: Victoria Gudiño; Raquel Bartolomé-Casado; Azucena Salas
Publicado en: Gut, 2025, ISSN 1468-3288
Editor: BMJ Group
DOI: 10.1136/GUTJNL-2024-334165

Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease

Autores: Bo-Jun Ke, Saeed Abdurahiman, Francesca Biscu, Gaia Zanella, Gabriele Dragoni, Sneha Santhosh, Veronica De Simone, Anissa Zouzaf, Lies van Baarle, Michelle Stakenborg, Veronika Bosáková, Yentl Van Rymenant, Emile Verhulst, Sare Verstockt, Elliott Klein, Gabriele Bislenghi, Albert Wolthuis, Jan Frič, Christine Breynaert, Andre D’Hoore, Pieter Van der Veken, Ingrid De Meester, Sara Lovisa, Lukas J.A.C. Hawinkels, Bram Verstockt, Gert De Hertogh, Séverine Vermeire, Gianluca Matteoli
Publicado en: Journal of Clinical Investigation, Edición 134, 2024, ISSN 1558-8238
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI173835

Discrimination between Inflammatory and Fibrotic Activity in Crohn’s Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging

Autores: Michael Beck, Torsten Kuwert, Armin Atzinger, Maximilian Gerner, Arndt Hartmann, Marc Saake, Michael Uder, Markus Friedrich Neurath, Raja Atreya
Publicado en: Visceral Medicine, 2024, ISSN 2297-4725
Editor: S. Karger AG
DOI: 10.1159/000542160

NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases

Autores: Simone Weber, Selina Sitte, Anna-Lena Voegele, Ludmilla Sologub, Angelika Wilfer, Timo Rath, Andreas Nägel, Sebastian Zundler, Luigi Franchi, Anthony W Opipari, Sophia Sonnewald, Stephen Reid, Arndt Hartmann, Philip Eichhorn, Claudia Handtrack, Klaus Weber, Robert Grützmann, Clemens Neufert, Vera S Schellerer, Elisabeth Naschberger, Arif B Ekici, Christian Büttner, Markus F Neurath, Raja Atreya
Publicado en: Journal of Crohn's and Colitis, Edición 18, 2024, ISSN 1873-9946
Editor: Oxford University Press (OUP)
DOI: 10.1093/ecco-jcc/jjad164

Therapeutic potential of Janus kinase inhibitors for the management of fibrosis in inflammatory bowel disease

Autores: Jie Su; Dalia A Lartey; Gaia Zanella; Lukas J A C Hawinkels; Gianluca Matteoli; Mark Löwenberg; Marieke C Barnhoorn
Publicado en: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Editor: Oxford University Press
DOI: 10.1093/ECCO-JCC/JJAF087

The Impact of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn’s Disease

Autores: Dragoni, Gabriele; Ke, Bo-Jun; Picariello, Lucia; Abdurahiman, Saeed; Ceni, Elisabetta; Biscu, Francesca; Mello, Tommaso; Polvani, Simone; Innocenti, Tommaso; Spalart, Valérie; Milani, Stefano; D'Hoore, André; Bislenghi, Gabriele; Scaringi, Stefano; Verstockt, Bram; De Hertogh, Gert; Martinod, Kimberly; Galli, Andrea; Matteoli, Gianluca; Vermeire, Séverine
Publicado en: Journal of Crohn's and Colitis, 2024, ISSN 1876-4479
Editor: Oxford University Press
DOI: 10.1093/ECCO-JCC/JJAE121