Objective BAXERNA 2.0 will establish a new vaccine development pipeline based on dramatically improved immunopeptidomics screening and innovative mRNA vaccine formulation. We will use our powerful new pipeline to develop novel mRNA vaccines against three bacterial pathogens that can persist within phagocytic cells: Mycobacterium tuberculosis (MTB), Mycobacterium ulcerans (MU), and Acinetobacter baumannii (AB). MTB and AB are clinically problematic bacteria with alarming levels of antimicrobial resistance (AMR), while MU is an important neglected tropical disease. Although vaccines are recognized as highly effective tools to mitigate AMR and tropical diseases, effective vaccine development for these (facultative) intracellular bacteria is held back by a lack of known antigens, and by current vaccine platforms struggling to elicit the required strong cellular immune responses. We will overcome both limitations here through two key innovations: (i) novel proteomics and proteomics informatics approaches for immunopeptidomics to allow highly sensitive discovery and prioritization of bacterial epitopes presented on infected cells; and (ii) novel mRNA vaccines to induce both humoral and cellular immune responses, with innovative adjuvants to strengthen adaptive immunity, and to modulate innate immunity. Vaccine production will be done according to GMP standards, and we will pursue novel, low-cost production methods to enable local production and much-needed improved vaccine stability.We will characterize innate and adaptive immune responses in detail in human cellular models and mouse infection models. In addition, top vaccine candidates for MTB will be evaluated in unique primate models, followed by testing of the lead candidate in a first-in-human Phase I clinical trial.Together, we will establish our novel vaccine development pipeline as a blueprint for world-leading, next-generation bacterial vaccine development. Fields of science medical and health scienceshealth sciencestropical medicinenatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Keywords Tuberculosis Buruli ulcer Acinetobacter baumannii mass spectrometry proteomics bioinformatics mRNA vaccine adjuvants innate immunity trained immunity lipid nanoparticle clinical trial Programme(s) HORIZON.2.1 - Health Main Programme HORIZON.2.1.4 - Infectious Diseases, including poverty-related and neglected diseases Topic(s) HORIZON-HLTH-2022-DISEASE-06-03-two-stage - Vaccines 2.0 - developing the next generation of vaccines Call for proposal HORIZON-HLTH-2022-DISEASE-06-two-stage See other projects for this call Funding Scheme HORIZON-RIA - HORIZON Research and Innovation Actions Coordinator VIB VZW Net EU contribution € 2 160 140,00 Address SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT Belgium See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 160 140,00 Participants (9) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITEIT GENT Belgium Net EU contribution € 3 202 800,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 3 202 800,00 KAROLINSKA INSTITUTET Sweden Net EU contribution € 817 500,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 817 500,00 INSTITUT PASTEUR France Net EU contribution € 671 300,00 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 671 300,00 STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM Netherlands Net EU contribution € 529 832,50 Address GEERT GROOTEPLEIN 10 ZUID 6525 GA Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 529 832,50 RHEAVITA Belgium Net EU contribution € 180 000,00 Address FRIEDA SAEYSSTRAAT 1 9052 Gent See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 180 000,00 UNIVERSITE LIBRE DE BRUXELLES Belgium Net EU contribution € 575 000,00 Address AVENUE FRANKLIN ROOSEVELT 50 1050 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 575 000,00 UNIVERCELLS Belgium Net EU contribution € 180 000,00 Address ZONING DE JUMET AVENUE CENTRALE 52 6040 Charleroi See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Région wallonne Prov. Hainaut Arr. Charleroi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 180 000,00 VRIJE UNIVERSITEIT BRUSSEL Belgium Net EU contribution € 597 000,00 Address PLEINLAAN 2 1050 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 597 000,00 OMNISCOPE LIMITED Malta Net EU contribution € 545 228,75 Address 30/1, KENILWORTH COURT, SIR AUGUSTUS BARTOLO STREE XBX 1093 TA XBIEX See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Malta Malta Malta Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 545 228,75 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all VACCINE FORMULATION INSTITUTE(CH)LTD Switzerland Net EU contribution € 0,00 Address RUE DU CHAMP-BLANCHOD 4 1228 Plan Les Ouates See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
