Novel advanced and repurposed therapeutics for vision restoration in a group of severe rare ocular surface diseases: from validation to first clinical investigations

Project Information

RESTORE VISION

Grant agreement ID: 101080611

DOI

10.3030/101080611

EC signature date 6 April 2023

Start date 1 May 2023

End date 30 April 2027

Funded under

• Health

Total cost

€ 8 049 852,25

EU contribution

€ 7 999 851,75

Coordinated by

UNIVERSITY OF GALWAY
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

First version of DMP

DMP will be prepared and updated throughout the project.

Websites, patent fillings, videos etc. (1)

Project Website

Public project website will be launched in Month 3 of the project. Partners and WP leads will be clearly stated on the website.

Publications

Peer reviewed articles (12)

Excipients in drug delivery systems: A comprehensive review of approved inactive ingredients for human ophthalmic formulations

Author(s): Raquel Gregorio Arribada, Daniela Rodrigues-Braz, Armando Silva-Cunha, Francine Behar-Cohen
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 208, 2025, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/J.EJPB.2025.114637

A Novel Rat Model for Human Meibomian Gland Dysfunction and Ocular Rosacea

Author(s): Linxin Zhu, Daniela Rodrigues-Braz, Emmanuelle Gélizé, Marine Crépin, Caroline Peltier, Coralie Lheure, Xavier Morel, Jean-Louis Bourges, Olivier Berdeaux, Francine Behar-Cohen, Min Zhao
Published in: Investigative Ophthalmology & Visual Science, Issue 67, 2026, ISSN 1552-5783
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/IOVS.67.1.14

Spironolactone Eyedrop Favors Restoration of Corneal Integrity after Wound Healing in the Rat

Author(s): Daniela Rodrigues-Braz, Linxin Zhu, Emmanuelle Gélizé, Jean-Pierre Clarin, Xavier Chatagnon, Youcef Benzine, Philippe Rampignon, Agathe Thouvenin, Jean-Louis Bourges, Francine Behar-Cohen, Min Zhao
Published in: Pharmaceuticals, Issue 16, 2023, ISSN 1424-8247
Publisher: MDPI AG
DOI: 10.3390/ph16101446

Central Corneal Epithelial Wounding Accelerates Aniridia-Associated Keratopathy in PAX6-Deficient Mice

Author(s): Yedizza Rautavaara, Israa Sefawi, Meri Vattulainen, Petros Moustardas, Dina Javidjam, Ava Dashti, Neil Lagali
Published in: Investigative Ophthalmology & Visual Science, Issue 66, 2025, ISSN 1552-5783
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/IOVS.66.14.33

Selective, Temporary Postoperative Inhibition of Lymphangiogenesis by Integrin α5β1 Blockade Improves Allograft Survival in a Murine Model of High-Risk Corneal Transplantation

Author(s): Tina Dietrich-Ntoukas, Felix Bock, Jasmine Onderka, Deniz Hos, Bjoern O. Bachmann, Grit Zahn, Claus Cursiefen
Published in: Journal of Clinical Medicine, Issue 13, 2024, ISSN 2077-0383
Publisher: MDPI AG
DOI: 10.3390/jcm13154418

Transcriptomic Analysis in a Model of Aniridia-Associated Keratopathy for Target Discovery and Evaluation of Duloxetine Therapy

Author(s): Dina Javidjam, Petros Moustardas, Ava Dashti, Daniel Aberdam, Arnaud Schweitzer-Chaput, Salvatore Cisternino, Dominique Bremond-Gignac, Neil Lagali
Published in: Investigative Ophthalmology & Visual Science, Issue 67, 2026, ISSN 1552-5783
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/IOVS.67.1.37

In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells

Author(s): Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter
Published in: Stem Cell Research & Therapy, Issue 16, 2025, ISSN 1757-6512
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13287-025-04476-2

Healing the Cornea: Exploring the Therapeutic Solutions Offered by MSCs and MSC-derived EVs

Author(s): Manon Jammes, Abbas Tabasi, Trung Bach, Thomas Ritter
Published in: Progress in Retinal and Eye Research, 2024, ISSN 1350-9462
Publisher: Elsevier BV
DOI: 10.1016/J.PRETEYERES.2024.101325

Mineralocorticoid receptor antagonism improves corneal integrity in a rat model of limbal stem cell deficiency

Author(s): Daniela Rodrigues-Braz, Clémence Bonnet, Linxin Zhu, Nilufer Yesilirmak, Emmanuelle Gélizé, Laurent Jonet, Frédéric Jaisser, Jean-Louis Bourges, Francine Behar-Cohen, Min Zhao
Published in: Biomedicine & Pharmacotherapy, Issue 185, 2025, ISSN 0753-3322
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.117979

Cross-species transcriptomics identify mineralocorticoid receptor pathway overactivation as a central driver of ocular rosacea

Author(s): Linxin Zhu, Nilufer Yesilirmak, Daniela Rodrigues-Braz, Emmanuelle Gélizé, Coralie Lheure, Xavier Morel, Jean-Louis Bourges, Frédéric Jaisser, Min ZHAO, Francine Behar-Cohen
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-71945-4

Comparison of in-vitro immunomodulatory capacity between large and small apoptotic bodies from human bone marrow mesenchymal stromal cells

Author(s): Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter
Published in: International Immunopharmacology, Issue 153, 2025, ISSN 1567-5769
Publisher: Elsevier BV
DOI: 10.1016/J.INTIMP.2025.114480

Targeting insulin receptor substrate-1 delays disease progression in a murine model of aniridia-associated keratopathy

Author(s): Ava Dashti, Petros Moustardas, Yedizza Rautavaara, Dina Javidjam, Israa Sefawi, Neil Lagali
Published in: Biomedicine & Pharmacotherapy, Issue 191, 2026, ISSN 0753-3322
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.118506