Novel advanced and repurposed therapeutics for vision restoration in a group of severe rare ocular surface diseases: from validation to first clinical investigations

Informazioni relative al progetto

RESTORE VISION

ID dell’accordo di sovvenzione: 101080611

DOI

10.3030/101080611

Data della firma CE 6 Aprile 2023

Data di avvio 1 Maggio 2023

Data di completamento 30 Aprile 2027

Finanziato da

• Health

Costo totale

€ 8 049 852,25

Contributo UE

€ 7 999 851,75

Coordinato da

UNIVERSITY OF GALWAY
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (1)

First version of DMP

DMP will be prepared and updated throughout the project.

Websites, patent fillings, videos etc. (1)

Project Website

Public project website will be launched in Month 3 of the project. Partners and WP leads will be clearly stated on the website.

Pubblicazioni

Peer reviewed articles (12)

Excipients in drug delivery systems: A comprehensive review of approved inactive ingredients for human ophthalmic formulations

Autori: Raquel Gregorio Arribada, Daniela Rodrigues-Braz, Armando Silva-Cunha, Francine Behar-Cohen
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, Numero 208, 2025, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/J.EJPB.2025.114637

A Novel Rat Model for Human Meibomian Gland Dysfunction and Ocular Rosacea

Autori: Linxin Zhu, Daniela Rodrigues-Braz, Emmanuelle Gélizé, Marine Crépin, Caroline Peltier, Coralie Lheure, Xavier Morel, Jean-Louis Bourges, Olivier Berdeaux, Francine Behar-Cohen, Min Zhao
Pubblicato in: Investigative Ophthalmology & Visual Science, Numero 67, 2026, ISSN 1552-5783
Editore: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/IOVS.67.1.14

Spironolactone Eyedrop Favors Restoration of Corneal Integrity after Wound Healing in the Rat

Autori: Daniela Rodrigues-Braz, Linxin Zhu, Emmanuelle Gélizé, Jean-Pierre Clarin, Xavier Chatagnon, Youcef Benzine, Philippe Rampignon, Agathe Thouvenin, Jean-Louis Bourges, Francine Behar-Cohen, Min Zhao
Pubblicato in: Pharmaceuticals, Numero 16, 2023, ISSN 1424-8247
Editore: MDPI AG
DOI: 10.3390/ph16101446

Central Corneal Epithelial Wounding Accelerates Aniridia-Associated Keratopathy in PAX6-Deficient Mice

Autori: Yedizza Rautavaara, Israa Sefawi, Meri Vattulainen, Petros Moustardas, Dina Javidjam, Ava Dashti, Neil Lagali
Pubblicato in: Investigative Ophthalmology & Visual Science, Numero 66, 2025, ISSN 1552-5783
Editore: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/IOVS.66.14.33

Selective, Temporary Postoperative Inhibition of Lymphangiogenesis by Integrin α5β1 Blockade Improves Allograft Survival in a Murine Model of High-Risk Corneal Transplantation

Autori: Tina Dietrich-Ntoukas, Felix Bock, Jasmine Onderka, Deniz Hos, Bjoern O. Bachmann, Grit Zahn, Claus Cursiefen
Pubblicato in: Journal of Clinical Medicine, Numero 13, 2024, ISSN 2077-0383
Editore: MDPI AG
DOI: 10.3390/jcm13154418

Transcriptomic Analysis in a Model of Aniridia-Associated Keratopathy for Target Discovery and Evaluation of Duloxetine Therapy

Autori: Dina Javidjam, Petros Moustardas, Ava Dashti, Daniel Aberdam, Arnaud Schweitzer-Chaput, Salvatore Cisternino, Dominique Bremond-Gignac, Neil Lagali
Pubblicato in: Investigative Ophthalmology & Visual Science, Numero 67, 2026, ISSN 1552-5783
Editore: Association for Research in Vision and Ophthalmology (ARVO)
DOI: 10.1167/IOVS.67.1.37

In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells

Autori: Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter
Pubblicato in: Stem Cell Research & Therapy, Numero 16, 2025, ISSN 1757-6512
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13287-025-04476-2

Healing the Cornea: Exploring the Therapeutic Solutions Offered by MSCs and MSC-derived EVs

Autori: Manon Jammes, Abbas Tabasi, Trung Bach, Thomas Ritter
Pubblicato in: Progress in Retinal and Eye Research, 2024, ISSN 1350-9462
Editore: Elsevier BV
DOI: 10.1016/J.PRETEYERES.2024.101325

Mineralocorticoid receptor antagonism improves corneal integrity in a rat model of limbal stem cell deficiency

Autori: Daniela Rodrigues-Braz, Clémence Bonnet, Linxin Zhu, Nilufer Yesilirmak, Emmanuelle Gélizé, Laurent Jonet, Frédéric Jaisser, Jean-Louis Bourges, Francine Behar-Cohen, Min Zhao
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 185, 2025, ISSN 0753-3322
Editore: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.117979

Cross-species transcriptomics identify mineralocorticoid receptor pathway overactivation as a central driver of ocular rosacea

Autori: Linxin Zhu, Nilufer Yesilirmak, Daniela Rodrigues-Braz, Emmanuelle Gélizé, Coralie Lheure, Xavier Morel, Jean-Louis Bourges, Frédéric Jaisser, Min ZHAO, Francine Behar-Cohen
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-71945-4

Comparison of in-vitro immunomodulatory capacity between large and small apoptotic bodies from human bone marrow mesenchymal stromal cells

Autori: Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter
Pubblicato in: International Immunopharmacology, Numero 153, 2025, ISSN 1567-5769
Editore: Elsevier BV
DOI: 10.1016/J.INTIMP.2025.114480

Targeting insulin receptor substrate-1 delays disease progression in a murine model of aniridia-associated keratopathy

Autori: Ava Dashti, Petros Moustardas, Yedizza Rautavaara, Dina Javidjam, Israa Sefawi, Neil Lagali
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 191, 2026, ISSN 0753-3322
Editore: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.118506