Stratification of Patients using advanced Integrative modeling of Data Routinely acquired for diagnosing Rheumatic complaints

Project Information

SPIDeRR

Grant agreement ID: 101080711

DOI

10.3030/101080711

EC signature date 20 March 2023

Start date 1 May 2023

End date 30 April 2028

Funded under

• Health

Total cost

€ 5 183 000,00

EU contribution

€ 5 183 000,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (3)

First annual newsletter

Updating general public and patient stakeholders in particular

SPIDeRR website

Website launch

Project video

Promotional video for international communication to stakeholders and general public

Documents, reports (4)

Outline of the patient journey, qualitative

Pan-European based on stakeholders interviews

Protocol on feasibility and actionability studies

Protocol paper written for WP6 studies

The Rheumatic Digital Twin protocol

Protocol paper on how to create the rheumatic digital twin

Ethical checklist

For unbiased and explainable computational models

Demonstrators, pilots, prototypes (2)

Protocol of Rheumatic?

Rheumatic? analysis protocol written

Protocol publication of Modular-SPIDeRR

Modular-SPIDeRR analysis protocol published

Data Management Plan (2)

Data management plan

DMP written and internally available

DMP update 1

Updated DMP

Publications

Conference proceedings (20)

AB0696IMPACT OF INCIDENT RA ON TRAJECTORIES FOR EARNINGS: NATIONWIDE SIBLING COMPARISON STUDY

Author(s): H. Miller, M. Neovius, J. Askling, G. Bruze
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.4505

AB1520THE PERSPECTIVE OF DUTCH HEALTH CARE PROFESSIONALS ON THE USE OF ARTIFICIAL INTELLIGENCE IN RHEUMATOLOGY

Author(s): L. M. Verhoef, H. J. Bernelot Moens, N. Steinz, H. E. Vonkeman, R. Knevel
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.931

AB0597CLINICAL AND LABORATORY EXAMINATIONS THE FIRST 3 MONTHS PREDICT REMISSION AT 6 AND 12 MONTHS; RESULTS FROM A COLLABORATIVE STUDY ON TWO NORWEGIAN COHORTS OF EARLY OR ESTABLISHED RHEUMATOID ARTHRITIS

Author(s): H. B. Hammer, J. Sexton, S. Lillegraven, L. Mathsson-Alm, I. Gehring, B. Glintborg, J. Askling, E. A. Haavardsholm
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.4343

POS1052PREDICTING FIBROMYALGIA OUTCOME FROM A RHEUMATIC-SPECIFIC SURVEY

Author(s): D. Selani, L. Qin, F. Zegers, L. Klareskog, E. Steyerberg, S. Le Cessie, B. Axns, M. J. T. Reinders, E. B. Van den Akker, R. Knevel
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2837

OP0033FIBROBLAST GENE, FKBP7 INDUCED BY Ca²⁺DEPENDENT ER STRESS ASSOCIATED WITH CLINICAL OUTCOME IN RHEUMATOID ARTHRITIS AND CROHNS DISEASE; MULTI-CENTRE GWAS AND FUNCTIONAL STUDIES

Author(s): M. P. Maurits, A. Cameron, S. Jelinsky, S. Blml, L. Abasolo, J. Askling, A. Barton, S. Bhringer, A. Cope, S. De, P. Emery, S. Eyre, V. P. Gaddi, I. Gonzlez-lvaro, C. S. Goodyear, X. Hu, T. Huizinga, M. Johannesson, S. Jurado-Zapata, L. Klareskog, D. Lendrem, P. Martin, I. B. Mc Innes, R. Micheroli, A. Morgan, F. Morton, N. Naamane, Y. Nagafuchi, G. Orozco, L. Padyukov, C. Paterson, C. Pitzalis, D. Plant, D. Porter, L. Reynard, L. Rodriguez Rodriguez, D. Sieghart, P. Studenic, J. Taylor, R. E. M. Toes, E. B. Van den Akker, A. H. M. Van der Helm van Mil, L. Vaskimo, S. Verstappen, H. Westerlind, J. Isaacs, M. Lewis, A. Pratt, C. Ospelt, A. Winkler, R. Thomas, R. Knevel
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2788

POS1377REFINING AUTOANTIBODY PROFILES IN PATIENTS WITH RHEUMATOID ARTHRITIS A SCANDINAVIAN STUDY ON 6900 SAMPLES

Author(s): J. Askling, C. Grnwall, H. Westerlind, L. Mathsson-Alm, I. Gehring, J. Sexton, S. Lillegraven, E. Haavardsholm, M. Lund Hetland, H. B. Hammer, B. Glintborg
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.3887

- ANALYSIS OF RHEUMATIC PATIENTS SELF- REPORTED SYMPTOMS IN FREE TEXT UDINH NATURAL LANGUAGE PROCESSING

Author(s): I. Prez Sancristbal, R. Knevel et. al.
Published in: 2024
Publisher: ACR

POS0589 EHR DEFINED BASELINE RA-SUBSETS CHARACTERISED BY LOCALISED JOINT INVOLVEMENT DIFFERENTIALLY ASSOCIATE WITH GENETIC RISK AND CLINICAL OUTCOMES BEYOND BASELINE

Author(s): T. D. Maarseveen, M. P. Maurits, S. Böhringer, N. Steinz, S. A. Bergstra, B. M. Boxma-De Klerk, A. H. M. Van der Helm – Van Mil, C. F. Allaart, M. J. T. Reinders, T. Huizinga, E. B. Van Den Akker, R. Knevel
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1924

POS0952COST-OF-ILLNESS AMONG PATIENTS WITH PSORIATIC ARTHRITIS IN SWEDEN

Author(s): J. K. Wallman, S. Exarchou, D. Di Giuseppe, U. Lindstrm, T. Olofsson, L. T. H. Jacobsson, J. Askling
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.207

OP0018 DISSECTING EARLY RA PATIENT TRAJECTORIES THROUGH TIME-INDEPENDENT DISEASE STATE IDENTIFICATION IDENTIFIES DISTINCT PATTERNS DISSECTED BY INFLAMMATION IN BLOOD OR JOINTS

Author(s): N. Steinz, T. D. Maarseveen, A. Cope, J. Isaacs, A. Winkler, T. Huizinga, A. Yann, R. Knevel
Published in: Scientific Abstracts, 2024, ISSN 1468-2060
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1512

OP0114CHANNELING BIAS AND ADVERSE EVENTS IN RA PATIENTS TREATED WITH B/TSDMARDS DO NEW DRUGS APPEAR MORE DANGEROUS THE FIRST YEARS AFTER MARKET ENTRY?

Author(s): V. Molander, H. Bower, T. Frisell, J. Askling
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.235

POS0594NEW INSIGHTS INTO EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS SUBTYPES THROUGH SEROLOGIC BIOMARKER PROFILING RESULTS FROM THE SCANDRA PROJECT

Author(s): J. Rojas-Restrepo, I. Gehring, N. Ghasemzadeh, L. Christiansson, L. Mathsson-Alm, E. A. Haavardsholm, T. K. Kvien, M. D. Mjaavatten, H. Westerlind, H. B. Hammer, J. Askling, null null
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2925

OP0131OCCURRENCE AND PREDICTORS OF MULTIPLE DMARD TREATMENT FAILURE IN RHEUMATID ARTHRITIS (RA): RESULTS FROM THE SWEDISH RHEUMATOLOGY QUALITY REGISTER

Author(s): E. Birgersson Wettersand, D. DI Giuseppe, J. Askling, K. Chatzidionysiou
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.4482

POS0750 WHO PARTICIPATES IN AN ONLINE SYMPTOM CHECKER? CHARACTERISTICS, ATTRITION AND REPRESENTATIVENESS IN THE RHEUMATIC? STUDY

Author(s): F. Zegers, L. Qin, D. Selani, G. Gomon, T. D. Maarseveen, H. K. Glas, A. Van Tubergen, Y. Goekoop-Ruiterman, M. J. T. Reinders, E. B. Van den Akker, C. Baatenburg de Jong, L. Klareskog, B. Axnäs, E. Steyerberg, R. Bos, S. Le Cessie, R. Knevel
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2253

POS0587 EMPLOYING MACHINE LEARNING TO PREDICT RA DIAGNOSIS FROM REFERRAL LETTERS BY THE GENERAL PRACTITIONER

Author(s): T. D. Maarseveen, H. K. Glas, J. Veris-Van Dieren, R. Knevel
Published in: Scientific Abstracts, 2024, ISSN 1468-2060
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1728

POS0633IMPACT OF GENETICS ON PREDICTING PERSISTENCE TO TREATMENT WITH METHOTREXATE IN EARLY RHEUMATOID ARTHRITIS

Author(s): A. berg Sysojev, B. Delcoigne, T. Frisell, L. Alfredsson, L. Klareskog, E. Baecklund, L. Bjrkman, A. Kastbom, S. Rantap Dahlqvist, C. Turesson, M. Boman, L. Padyukov, J. Askling, H. Westerlind
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2921

POS0629IDENTIFICATION OF RA PHENOTYPES USING UNSUPERVISED CLUSTERING

Author(s): S. Steiger, H. Westerlind, D. DI Giuseppe, J. Askling
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2226

POS0586ANTI-TYPE II COLLAGEN ANTIBODIES ASSOCIATE WITH HIGH LEVELS OF INFLAMMATION AT DIAGNOSIS BUT WITH GOOD CLINICAL OUTCOME A STUDY BASED ON THE NORWEGIAN EARLY RHEUMATOID ARTHRITIS ARCTIC COHORT

Author(s): J. Rnnelid, C. Mller Westerberg, A. Svanqvist, H. B. Hammer, J. Sexton, L. Mathsson, I. Gehring, J. Askling, H. Westerlind, S. Lillegraven, E. A. Haavardsholm
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1635

AB1448DIFFERENTIATION OF IMMUNE MEDIATED VERSUS NON IMMUNE MEDIATED RHEUMATIC DISEASES BY ONLINE SYMPTOM CHECKER IN REAL-WORLD PATIENTS MULTIPLE DIAGNOSES AND PARTICULARLY FIBROMYALGIA IS A STUMBLING BLOCK

Author(s): L. Qin, F. Zegers, D. Selani, E. B. Van den Akker, R. Bos, S. Le Cessie, I. Gehring, H. K. Glas, M. Johannesson, J. Knitza, L. Mathsson-Alm, M. J. T. Reinders, E. Steyerberg, A. Van Tubergen, L. M. Verhoef, B. Axns, L. Klareskog, R. Knevel, null null
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.5438

AB1480STRATIFICATION OF PATIENTS USING ADVANCED INTEGRATIVE MODELLING OF DATA ROUTINELY ACQUIRED FOR DIAGNOSING RHEUMATIC COMPLAINTS (SPIDeRR): A MULTICENTER EUROPEAN CONSORTIUM

Author(s): J. Desai, E. Van den Akker, J. Askling, B. Axns, A. Banos, L. Carmona, L. Christiansson, M. Hulsinga, D. De Jong, J. Knitza, H. Morf, F. Muehlensiepen, A. Pratt, G. Nagy, J. Newton, L. Rodriguez Rodriguez, D. Schiphof, S. Viatte, M. Villalobos Quesada, R. Knevel
Published in: Scientific Abstracts, 2024
Publisher: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.5262

Peer reviewed articles (3)

Journal of Medical Internet Research

Author(s): Johannes Knitza; Koray Tascilar; Franziska Fuchs; Jacob Mohn; Sebastian Kuhn; Daniela Bohr; Felix Muehlensiepen; Christina Bergmann; Hannah Labinsky; Harriet Morf; Elizabeth Araujo; Matthias Englbrecht; Wolfgang Vorbrggen; Cay-Benedict von der Decken; Stefan Kleinert; Andreas Ramming; Jrg H W Distler; Peter Bartz-Bazzanella; Nicolas Vuillerme; Georg Schett; Martin Welcker; Axel Hueber
Published in: Journal of Medical Internet Research, 2024, ISSN 1438-8871
Publisher: Journal of medical Internet Research
DOI: 10.2196/55542

The Application of Genetic Risk Scores in Rheumatic Diseases: A Perspective

Author(s): Lotta M. Vaskimo, Georgy Gomon, Najib Naamane, Heather J. Cordell, Arthur Pratt, Rachel Knevel
Published in: Genes, Issue 14, 2023, ISSN 2073-4425
Publisher: MDPI AG
DOI: 10.3390/genes14122167

Recommendation to implementation of remote patient monitoring in rheumatology: lessons learned and barriers to take

Author(s): Philip Hamann; Johannes Knitza; Sebastian Kuhn; Rachel Knevel
Published in: RMD Open, Vol 9, Iss 4 (2023), 2023, ISSN 1468-2060
Publisher: Elsevier
DOI: 10.1136/rmdopen-2023-003363