Stratification of Patients using advanced Integrative modeling of Data Routinely acquired for diagnosing Rheumatic complaints

Información del proyecto

SPIDeRR

Identificador del acuerdo de subvención: 101080711

DOI

10.3030/101080711

Fecha de la firma de la CE 20 Marzo 2023

Fecha de inicio 1 Mayo 2023

Fecha de finalización 30 Abril 2028

Financiado con arreglo a

• Health

Coste total

€ 5 182 424,97

Aportación de la UE

€ 5 182 424,97

Coordinado por

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (3)

First annual newsletter

Updating general public and patient stakeholders in particular

SPIDeRR website

Website launch

Project video

Promotional video for international communication to stakeholders and general public

Documents, reports (4)

Outline of the patient journey, qualitative

Pan-European based on stakeholders interviews

Protocol on feasibility and actionability studies

Protocol paper written for WP6 studies

The Rheumatic Digital Twin protocol

Protocol paper on how to create the rheumatic digital twin

Ethical checklist

For unbiased and explainable computational models

Demonstrators, pilots, prototypes (2)

Protocol of Rheumatic?

Rheumatic? analysis protocol written

Protocol publication of Modular-SPIDeRR

Modular-SPIDeRR analysis protocol published

Data Management Plan (2)

Data management plan

DMP written and internally available

DMP update 1

Updated DMP

Publicaciones

Conference proceedings (22)

AB0696IMPACT OF INCIDENT RA ON TRAJECTORIES FOR EARNINGS: NATIONWIDE SIBLING COMPARISON STUDY

Autores: H. Miller, M. Neovius, J. Askling, G. Bruze
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.4505

AB1520THE PERSPECTIVE OF DUTCH HEALTH CARE PROFESSIONALS ON THE USE OF ARTIFICIAL INTELLIGENCE IN RHEUMATOLOGY

Autores: L. M. Verhoef, H. J. Bernelot Moens, N. Steinz, H. E. Vonkeman, R. Knevel
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.931

Additional file 1 of Impact of the digital health application ViViRA on spinal mobility, physical function, quality of life and pain perception in spondyloarthritides patients: a randomized controlled trial

Autores: Blaskowitz, Paloma Palm von Alten; Liphardt, Anna-Maria; Bouzas, Claudia; Coppers, Birte; Petit, Pascal; Vuillerme, Nicolas; Bundle, Vanessa; Rudolf, Sebastian; Knitza, Johannes; Raimondo, Maria Gabriella; Labinsky, Hannah; Hatscher, Lukas; Wirsching, Andreas; Bohr, Daniela; Araujo, Elizabeth; Ramming, Andreas; Ramming, Alina; Schett, Georg; Morf, Harriet
Publicado en: 2024
Editor: Figshare
DOI: 10.6084/M9.FIGSHARE.27957940.V1

AB0597CLINICAL AND LABORATORY EXAMINATIONS THE FIRST 3 MONTHS PREDICT REMISSION AT 6 AND 12 MONTHS; RESULTS FROM A COLLABORATIVE STUDY ON TWO NORWEGIAN COHORTS OF EARLY OR ESTABLISHED RHEUMATOID ARTHRITIS

Autores: H. B. Hammer, J. Sexton, S. Lillegraven, L. Mathsson-Alm, I. Gehring, B. Glintborg, J. Askling, E. A. Haavardsholm
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.4343

POS1052PREDICTING FIBROMYALGIA OUTCOME FROM A RHEUMATIC-SPECIFIC SURVEY

Autores: D. Selani, L. Qin, F. Zegers, L. Klareskog, E. Steyerberg, S. Le Cessie, B. Axns, M. J. T. Reinders, E. B. Van den Akker, R. Knevel
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2837

OP0033FIBROBLAST GENE, FKBP7 INDUCED BY Ca²⁺DEPENDENT ER STRESS ASSOCIATED WITH CLINICAL OUTCOME IN RHEUMATOID ARTHRITIS AND CROHNS DISEASE; MULTI-CENTRE GWAS AND FUNCTIONAL STUDIES

Autores: M. P. Maurits, A. Cameron, S. Jelinsky, S. Blml, L. Abasolo, J. Askling, A. Barton, S. Bhringer, A. Cope, S. De, P. Emery, S. Eyre, V. P. Gaddi, I. Gonzlez-lvaro, C. S. Goodyear, X. Hu, T. Huizinga, M. Johannesson, S. Jurado-Zapata, L. Klareskog, D. Lendrem, P. Martin, I. B. Mc Innes, R. Micheroli, A. Morgan, F. Morton, N. Naamane, Y. Nagafuchi, G. Orozco, L. Padyukov, C. Paterson, C. Pitzalis, D. Plant, D. Porter, L. Reynard, L. Rodriguez Rodriguez, D. Sieghart, P. Studenic, J. Taylor, R. E. M. Toes, E. B. Van den Akker, A. H. M. Van der Helm van Mil, L. Vaskimo, S. Verstappen, H. Westerlind, J. Isaacs, M. Lewis, A. Pratt, C. Ospelt, A. Winkler, R. Thomas, R. Knevel
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2788

POS1377REFINING AUTOANTIBODY PROFILES IN PATIENTS WITH RHEUMATOID ARTHRITIS A SCANDINAVIAN STUDY ON 6900 SAMPLES

Autores: J. Askling, C. Grnwall, H. Westerlind, L. Mathsson-Alm, I. Gehring, J. Sexton, S. Lillegraven, E. Haavardsholm, M. Lund Hetland, H. B. Hammer, B. Glintborg
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.3887

- ANALYSIS OF RHEUMATIC PATIENTS SELF- REPORTED SYMPTOMS IN FREE TEXT UDINH NATURAL LANGUAGE PROCESSING

Autores: I. Prez Sancristbal, R. Knevel et. al.
Publicado en: 2024
Editor: ACR

POS0589 EHR DEFINED BASELINE RA-SUBSETS CHARACTERISED BY LOCALISED JOINT INVOLVEMENT DIFFERENTIALLY ASSOCIATE WITH GENETIC RISK AND CLINICAL OUTCOMES BEYOND BASELINE

Autores: T. D. Maarseveen, M. P. Maurits, S. Böhringer, N. Steinz, S. A. Bergstra, B. M. Boxma-De Klerk, A. H. M. Van der Helm – Van Mil, C. F. Allaart, M. J. T. Reinders, T. Huizinga, E. B. Van Den Akker, R. Knevel
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1924

POS0952COST-OF-ILLNESS AMONG PATIENTS WITH PSORIATIC ARTHRITIS IN SWEDEN

Autores: J. K. Wallman, S. Exarchou, D. Di Giuseppe, U. Lindstrm, T. Olofsson, L. T. H. Jacobsson, J. Askling
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.207

Autoantibody Profiles in Patients with Musculoskeletal Complaints

Autores: Lisa Christiansson
Publicado en: Auto immunity Abstract book 2024
Editor: Auto immunity Abstract book 2024

OP0018 DISSECTING EARLY RA PATIENT TRAJECTORIES THROUGH TIME-INDEPENDENT DISEASE STATE IDENTIFICATION IDENTIFIES DISTINCT PATTERNS DISSECTED BY INFLAMMATION IN BLOOD OR JOINTS

Autores: N. Steinz, T. D. Maarseveen, A. Cope, J. Isaacs, A. Winkler, T. Huizinga, A. Yann, R. Knevel
Publicado en: Scientific Abstracts, 2024, ISSN 1468-2060
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1512

OP0114CHANNELING BIAS AND ADVERSE EVENTS IN RA PATIENTS TREATED WITH B/TSDMARDS DO NEW DRUGS APPEAR MORE DANGEROUS THE FIRST YEARS AFTER MARKET ENTRY?

Autores: V. Molander, H. Bower, T. Frisell, J. Askling
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.235

POS0594NEW INSIGHTS INTO EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS SUBTYPES THROUGH SEROLOGIC BIOMARKER PROFILING RESULTS FROM THE SCANDRA PROJECT

Autores: J. Rojas-Restrepo, I. Gehring, N. Ghasemzadeh, L. Christiansson, L. Mathsson-Alm, E. A. Haavardsholm, T. K. Kvien, M. D. Mjaavatten, H. Westerlind, H. B. Hammer, J. Askling, null null
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2925

OP0131OCCURRENCE AND PREDICTORS OF MULTIPLE DMARD TREATMENT FAILURE IN RHEUMATID ARTHRITIS (RA): RESULTS FROM THE SWEDISH RHEUMATOLOGY QUALITY REGISTER

Autores: E. Birgersson Wettersand, D. DI Giuseppe, J. Askling, K. Chatzidionysiou
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.4482

POS0750 WHO PARTICIPATES IN AN ONLINE SYMPTOM CHECKER? CHARACTERISTICS, ATTRITION AND REPRESENTATIVENESS IN THE RHEUMATIC? STUDY

Autores: F. Zegers, L. Qin, D. Selani, G. Gomon, T. D. Maarseveen, H. K. Glas, A. Van Tubergen, Y. Goekoop-Ruiterman, M. J. T. Reinders, E. B. Van den Akker, C. Baatenburg de Jong, L. Klareskog, B. Axnäs, E. Steyerberg, R. Bos, S. Le Cessie, R. Knevel
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2253

POS0587 EMPLOYING MACHINE LEARNING TO PREDICT RA DIAGNOSIS FROM REFERRAL LETTERS BY THE GENERAL PRACTITIONER

Autores: T. D. Maarseveen, H. K. Glas, J. Veris-Van Dieren, R. Knevel
Publicado en: Scientific Abstracts, 2024, ISSN 1468-2060
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1728

POS0633IMPACT OF GENETICS ON PREDICTING PERSISTENCE TO TREATMENT WITH METHOTREXATE IN EARLY RHEUMATOID ARTHRITIS

Autores: A. berg Sysojev, B. Delcoigne, T. Frisell, L. Alfredsson, L. Klareskog, E. Baecklund, L. Bjrkman, A. Kastbom, S. Rantap Dahlqvist, C. Turesson, M. Boman, L. Padyukov, J. Askling, H. Westerlind
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2921

POS0629IDENTIFICATION OF RA PHENOTYPES USING UNSUPERVISED CLUSTERING

Autores: S. Steiger, H. Westerlind, D. DI Giuseppe, J. Askling
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2226

POS0586ANTI-TYPE II COLLAGEN ANTIBODIES ASSOCIATE WITH HIGH LEVELS OF INFLAMMATION AT DIAGNOSIS BUT WITH GOOD CLINICAL OUTCOME A STUDY BASED ON THE NORWEGIAN EARLY RHEUMATOID ARTHRITIS ARCTIC COHORT

Autores: J. Rnnelid, C. Mller Westerberg, A. Svanqvist, H. B. Hammer, J. Sexton, L. Mathsson, I. Gehring, J. Askling, H. Westerlind, S. Lillegraven, E. A. Haavardsholm
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1635

AB1448DIFFERENTIATION OF IMMUNE MEDIATED VERSUS NON IMMUNE MEDIATED RHEUMATIC DISEASES BY ONLINE SYMPTOM CHECKER IN REAL-WORLD PATIENTS MULTIPLE DIAGNOSES AND PARTICULARLY FIBROMYALGIA IS A STUMBLING BLOCK

Autores: L. Qin, F. Zegers, D. Selani, E. B. Van den Akker, R. Bos, S. Le Cessie, I. Gehring, H. K. Glas, M. Johannesson, J. Knitza, L. Mathsson-Alm, M. J. T. Reinders, E. Steyerberg, A. Van Tubergen, L. M. Verhoef, B. Axns, L. Klareskog, R. Knevel, null null
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.5438

AB1480STRATIFICATION OF PATIENTS USING ADVANCED INTEGRATIVE MODELLING OF DATA ROUTINELY ACQUIRED FOR DIAGNOSING RHEUMATIC COMPLAINTS (SPIDeRR): A MULTICENTER EUROPEAN CONSORTIUM

Autores: J. Desai, E. Van den Akker, J. Askling, B. Axns, A. Banos, L. Carmona, L. Christiansson, M. Hulsinga, D. De Jong, J. Knitza, H. Morf, F. Muehlensiepen, A. Pratt, G. Nagy, J. Newton, L. Rodriguez Rodriguez, D. Schiphof, S. Viatte, M. Villalobos Quesada, R. Knevel
Publicado en: Scientific Abstracts, 2024
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.5262

Peer reviewed articles (13)

POS0952 COST-OF-ILLNESS AMONG PATIENTS WITH PSORIATIC ARTHRITIS IN SWEDEN

Autores: Wallman, J.K.; Exarchou, S.; Di Giuseppe, D.; Lindström, U.; Olofsson, T.; Jacobsson, L.T.H.; Askling, J.
Publicado en: Annals of the Rheumatic Diseases, 2024, ISSN 1468-2060
Editor: BMJ Publishing Group Ltd
DOI: 10.1136/ANNRHEUMDIS-2024-EULAR.207

POS0587 EMPLOYING MACHINE LEARNING TO PREDICT RA DIAGNOSIS FROM REFERRAL LETTERS BY THE GENERAL PRACTITIONER

Autores: Maarseveen, T.D.; Glas, H.K.; Veris-Van Dieren, J.; Knevel, R.
Publicado en: Annals of the Rheumatic Diseases, 2024, ISSN 1468-2060
Editor: BMJ Publishing Group Ltd
DOI: 10.1136/ANNRHEUMDIS-2024-EULAR.1728

Journal of Medical Internet Research

Autores: Johannes Knitza; Koray Tascilar; Franziska Fuchs; Jacob Mohn; Sebastian Kuhn; Daniela Bohr; Felix Muehlensiepen; Christina Bergmann; Hannah Labinsky; Harriet Morf; Elizabeth Araujo; Matthias Englbrecht; Wolfgang Vorbrggen; Cay-Benedict von der Decken; Stefan Kleinert; Andreas Ramming; Jrg H W Distler; Peter Bartz-Bazzanella; Nicolas Vuillerme; Georg Schett; Martin Welcker; Axel Hueber
Publicado en: Journal of Medical Internet Research, 2024, ISSN 1438-8871
Editor: Journal of medical Internet Research
DOI: 10.2196/55542

POS0594 NEW INSIGHTS INTO EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS SUBTYPES THROUGH SEROLOGIC BIOMARKER PROFILING – RESULTS FROM THE SCANDRA PROJECT

Autores: Rojas-Restrepo, J.; Gehring, I.; Ghasemzadeh, N.; Christiansson, L.; Mathsson-Alm, L.; Haavardsholm, E.A.; Kvien, T.K.; Mjaavatten, M.D.; Westerlind, H.; Hammer, H.B.; Askling, J.
Publicado en: Annals of the Rheumatic Diseases, 2024, ISSN 1468-2060
Editor: BMJ Publishing Group Ltd
DOI: 10.1136/ANNRHEUMDIS-2024-EULAR.2925

The Application of Genetic Risk Scores in Rheumatic Diseases: A Perspective

Autores: Lotta M. Vaskimo, Georgy Gomon, Najib Naamane, Heather J. Cordell, Arthur Pratt, Rachel Knevel
Publicado en: Genes, Edición 14, 2023, ISSN 2073-4425
Editor: MDPI AG
DOI: 10.3390/genes14122167

AI-Enhanced Triage: Improving Musculoskeletal Care with Data Driven Screening of Referral Letters

Autores: Tjardo Daniël Maarseveen; Herman Kasper Glas; Josien Veris-van Dieren; Rachel Knevel
Publicado en: Crossref, 2024, ISSN 2693-5015
Editor: Research Square
DOI: 10.21203/RS.3.RS-5146275/V1

POS0633 IMPACT OF GENETICS ON PREDICTING PERSISTENCE TO TREATMENT WITH METHOTREXATE IN EARLY RHEUMATOID ARTHRITIS

Autores: Öberg Sysojev, A.; Delcoigne, B.; Frisell, T.; Alfredsson, L.; Klareskog, L.; Baecklund, E.; Björkman, L.; Kastbom, A.; Rantapää Dahlqvist, S.; Turesson, C.; Boman, M.; Padyukov, L.; Askling, J.; Westerlind, H.
Publicado en: Annals of the Rheumatic Diseases, 2024, ISSN 1468-2060
Editor: BMJ Publishing Group Ltd
DOI: 10.1136/ANNRHEUMDIS-2024-EULAR.2921

Recommendation to implementation of remote patient monitoring in rheumatology: lessons learned and barriers to take

Autores: Philip Hamann; Johannes Knitza; Sebastian Kuhn; Rachel Knevel
Publicado en: RMD Open, Vol 9, Iss 4 (2023), 2023, ISSN 1468-2060
Editor: Elsevier
DOI: 10.1136/rmdopen-2023-003363

Impact of the digital health application ViViRA on spinal mobility, physical function, quality of life and pain perception in patients with seronegative spondyloarthropathies: a randomized controlled trial

Autores: Paloma Palm von Alten Blaskowitz; Claudia Bouzas; Birte Coppers; Anna-Maria Liphardt; Pascal Petit; Nicolas Vuillerme; Vanessa Bundle; Sebastian Rudolf; Johannes Knitza; Maria Gabriella Raimondo; Hannah Labinsky; Lukas Hatscher; Andreas Wirsching; Daniela Bohr; Elizabeth Araujo; Andreas Ramming; Alina Ramming; Georg Schett; Harriet Morf
Publicado en: Crossref, 2024, ISSN 1478-6362
Editor: BioMed Central Ltd.
DOI: 10.21203/RS.3.RS-5032258/V1

AB1480 STRATIFICATION OF PATIENTS USING ADVANCED INTEGRATIVE MODELLING OF DATA ROUTINELY ACQUIRED FOR DIAGNOSING RHEUMATIC COMPLAINTS (SPIDeRR): A MULTICENTER EUROPEAN CONSORTIUM

Autores: Desai, J.; Van den Akker, E.; Askling, J.; Axnäs, B.; Banos, A.; Carmona, L.; Christiansson, L.; Hulsinga, M.; De Jong, D.; Knitza, J.; Morf, H.; Muehlensiepen, F.; Pratt, A.; Nagy, G.; Newton, J.; Rodriguez Rodriguez, L.; Schiphof, D.; Viatte, S.; Villalobos Quesada, M.; Knevel, R.
Publicado en: Annals of the Rheumatic Diseases, 2024, ISSN 1468-2060
Editor: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/ANNRHEUMDIS-2024-EULAR.5262

POS1377 REFINING AUTOANTIBODY PROFILES IN PATIENTS WITH RHEUMATOID ARTHRITIS – A SCANDINAVIAN STUDY ON 6900 SAMPLES

Autores: Askling, J.; Grönwall, C.; Westerlind, H.; Mathsson-Alm, L.; Gehring, I.; Sexton, J.; Lillegraven, S.; Haavardsholm, E.; Lund Hetland, M.; Hammer, H.B.; Glintborg, B.
Publicado en: Annals of the Rheumatic Diseases, 2024, ISSN 1468-2060
Editor: BMJ Publishing Group Ltd
DOI: 10.1136/ANNRHEUMDIS-2024-EULAR.3887

Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets

Autores: Maarseveen, T.D.; Maurits, M.P.; Coletto, L.A.; Perniola, S.; Böhringer, S.; Steinz, N.; Bergstra, S.A.; Bruno, D.; Gigante, M.R.; Pacucci, V.A.; Petricca, L.; Klerk, B.B.D.; Glas, H.K.; Mario, C. di; Campobasso, D.; Tolusso, B.; Dieren, J.V.V.; Mil, A.H.M.V.; Gremese, E.; D'Agostino, M.A.; Reinders, M.J.T.; Gessi, M.; Huizinga, T.W.J.; Alivernini, S.; Akker, E.B. van den; Knevel, R.
Publicado en: npj Digital Medicine, 2025, ISSN 2693-5015
Editor: Research Square
DOI: 10.1038/S41746-025-01997-1

Let’s ask the patient: disease prediction based on patients’ symptom descriptions in free text

Autores: Inés Pérez-Sancristóbal; Nils Steinz; Ling Qin; Tjardo Maarseveen; Floor Zegers; Barbara Bislawska Axnäs; Luis Rodríguez-Rodríguez; Rachel Knevel
Publicado en: Rheumatology Advances in Practice, 2025, ISSN 2514-1775
Editor: Oxford University Press
DOI: 10.1093/RAP/RKAF103