Engineered NK cells against cancer
Tumours have evolved mechanisms for evading immune system responses including T cell exhaustion. To address this problem, scientists have come up with immunotherapy strategies to awaken or reeducate the immune system against cancer. Chimeric antigen receptor (CAR) natural killer (NK) cells are genetically engineered to recognise a specific target antigen. Despite their great promise, CAR-NK cell production is laborious and costly. The ERC-funded CHEMCELL project aims to address this limitation through an innovative labelling and engineering approach. Researchers will produce antibody-modified NK cells and test them against conventional CAR-NK cells for their anti-cancer efficiency.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme