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Chemical Engineering of Natural Killer Cells for Cancer Immunotherapy

Project description

Engineered NK cells against cancer

Tumours have evolved mechanisms for evading immune system responses including T cell exhaustion. To address this problem, scientists have come up with immunotherapy strategies to awaken or reeducate the immune system against cancer. Chimeric antigen receptor (CAR) natural killer (NK) cells are genetically engineered to recognise a specific target antigen. Despite their great promise, CAR-NK cell production is laborious and costly. The ERC-funded CHEMCELL project aims to address this limitation through an innovative labelling and engineering approach. Researchers will produce antibody-modified NK cells and test them against conventional CAR-NK cells for their anti-cancer efficiency.

Coordinator

USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
Net EU contribution
€ 150 000,00
Address
Flemingovo Nam. 542/2
16610 Praha 6
Czechia

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Region
Praha Hlavní město Praha
Activity type
Research Organisations
Other funding
No data