Description du projet
Étude des effets sur la santé de l’eau appauvrie en deutérium
De fortes concentrations de deutérium dans l’eau provoquent un dysfonctionnement des mitochondries. Des concentrations extrêmement élevées peuvent également entraîner la mort cellulaire. L’eau appauvrie en deutérium (AD) semble représenter une solution sans danger, et des sociétés de l’UE vendent au public de l’eau AD à différentes concentrations. Cependant, nous ne comprenons pas entièrement les effets positifs de l’eau AD sur la santé. Le projet Aqua-Synapse, financé par l’UE, établira la base mécaniste des effets positifs de l’eau AD sur la santé et déterminera les régimes les plus efficaces. Le projet fera appel à des techniques d’imagerie avancées pour mesurer les flux métaboliques régionaux dans le corps d’animaux en bonne santé et de ceux soumis au stress consécutif à l’administration de l’eau AD à différentes concentrations et pendant différentes périodes.
Objectif
Core idea of this project is to establish the mechanistic basis for the positive health effects of deuterium depleted water and determine what regimens are most efficacious. Isotope content of drinking water has been shown affect the pathogenesis of cancers to ameliorate the stress response and reduce susceptibility to many diseases, but it remains unclear how the positive biological effects of heavy isotope reduction in drinking water are mediated. High concentrations of deuterium induce mitochondrial dysfunction, and very high concentrations can induce cell death, but the administration of deuterium at 91 ppm has antidepressant effects that were comparable to that of citalopram in a mouse model of depression. Use of deuterium depleted water appears to represent a safe intervention with few, if any, reported side effects, but it remains unclear at what concentrations the positive metabolic and behavioral effects become apparent. Companies in Europe now sell DDW at different concentrations to the public amidst a plethora of health claims that mostly lack in any sound scientific basis or safety data Thus, there is an urgent need to better understand the impact of DDW on brain and behavior at a molecular level. We will use state-of-the art imaging techniques to measure regional metabolic fluxes in the body of animals in healthy individuals throughout life and those subject to stress following the administration of DDW at different concentrations and for different periods. Also we examine how deuterium depletion affects the behaviors of neurons in vitro and electrophysiological levels and in terms of their metabolism. The project is made possible by bringing together a consortium of chemists, cell biologists, pharmacologists, imaging specialists, psychiatrists, and DDW producers for medicinal needs in fully translational work packages to discover, in an empiric manner, how the manipulation of metabolic pathways with DDW can be employed for the benefit of human health
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Appel à propositions
(s’ouvre dans une nouvelle fenêtre) HORIZON-MSCA-2021-SE-01
Voir d’autres projets de cet appelRégime de financement
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinateur
1749-024 LISBOA
Portugal