Descrizione del progetto
Studio degli effetti sulla salute dell’acqua povera di deuterio
Le alte concentrazioni di deuterio nell’acqua causano disfunzioni mitocondriali. Concentrazioni estremamente elevate possono anche portare alla morte cellulare. L’acqua povera di deuterio sembra rappresentare un intervento sicuro e diverse aziende dell’UE ne vendono a diverse concentrazioni al pubblico. Tuttavia, i suoi effetti positivi sulla salute non sono del tutto noti. Il progetto Aqua-Synapse, finanziato dall’UE, stabilirà la base meccanicistica degli effetti positivi dell’acqua povera di deuterio sulla salute e determinerà quali regimi sono più efficaci. Il progetto applicherà tecniche di imaging avanzate per misurare i flussi metabolici regionali nel corpo degli animali in individui sani e in quelli soggetti a stress in seguito a somministrazione di acqua povera di deuterio a diverse concentrazioni e per diversi periodi.
Obiettivo
Core idea of this project is to establish the mechanistic basis for the positive health effects of deuterium depleted water and determine what regimens are most efficacious. Isotope content of drinking water has been shown affect the pathogenesis of cancers to ameliorate the stress response and reduce susceptibility to many diseases, but it remains unclear how the positive biological effects of heavy isotope reduction in drinking water are mediated. High concentrations of deuterium induce mitochondrial dysfunction, and very high concentrations can induce cell death, but the administration of deuterium at 91 ppm has antidepressant effects that were comparable to that of citalopram in a mouse model of depression. Use of deuterium depleted water appears to represent a safe intervention with few, if any, reported side effects, but it remains unclear at what concentrations the positive metabolic and behavioral effects become apparent. Companies in Europe now sell DDW at different concentrations to the public amidst a plethora of health claims that mostly lack in any sound scientific basis or safety data Thus, there is an urgent need to better understand the impact of DDW on brain and behavior at a molecular level. We will use state-of-the art imaging techniques to measure regional metabolic fluxes in the body of animals in healthy individuals throughout life and those subject to stress following the administration of DDW at different concentrations and for different periods. Also we examine how deuterium depletion affects the behaviors of neurons in vitro and electrophysiological levels and in terms of their metabolism. The project is made possible by bringing together a consortium of chemists, cell biologists, pharmacologists, imaging specialists, psychiatrists, and DDW producers for medicinal needs in fully translational work packages to discover, in an empiric manner, how the manipulation of metabolic pathways with DDW can be employed for the benefit of human health
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Invito a presentare proposte
(si apre in una nuova finestra) HORIZON-MSCA-2021-SE-01
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HORIZON-TMA-MSCA-SE -Coordinatore
1749-024 LISBOA
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