Project description
Innovative strategies for borylated molecule manufacturing
Boron-containing compounds play a critical role in discovering and manufacturing several products used in daily life. The EU-funded BETELGEUSE project will invent innovative catalysis concepts based on the reactivity of boryl radicals, an underutilised class of reactive intermediates. The project proposes a novel approach to generating these species from amine-borane precursors. BETELGEUSE will establish a general platform to borylate aromatics using boryl radicals, explore boryl radicals in innovative cascades reactions, and establish boryl radicals as ‘H-atom transfer’ catalysts to achieve the ‘philicity umpolung’ of nucleophilic radicals. The results will offer unprecedented tools for borylated material synthesis and catalysis, enabling the discovery and manufacturing of new products that enhance daily life.
Objective
Our ability to construct organic molecules is central to the wellbeing of our society. Boron-containing compounds are some of the most used tools to aid this. These materials are used as building blocks when “stitching” molecules together and also as catalysts in many different settings. The invention of innovative strategies to prepare and exploit borylated molecules is integral to discover and manufacture many products that we use daily.
The overarching aim of this proposal is to innovate organic chemistry by inventing novel catalysis concepts based on the reactivity of boryl radicals, an underutilized class of reactive intermediates. My group has introduced a novel approach to generate these species from amine-borane precursors and here I aim to:
1. Establish a general platform to borylate aromatics using boryl radicals. This blueprint for C–B bond formation will introduce amine-borane functionalities instead of standard boronic acids/esters. This will provide unprecedented synthetic capacity because the amine-borane will serve a dual role acting first as directing group for ortho/meta functionalization and then cross-coupling handle.
2. Explore boryl radicals in innovative cascades reactions leading to the divergent assembly of sp3-rich fragments. These methods will expedite the preparation of poly-functionalized materials tapping into unexplored areas of chemical space.
3. Establish boryl radicals as “H-atom transfer” catalysts to achieve the “philicity umpolung” of nucleophilic radicals. This concept will introduce unprecedented retrosynthetic tactics and enable the merge of boryl radical reactivity with asymmetric organocatalysis.
Overall, this cohesive and innovative research plan offers the unique opportunity to discover novel and exciting transformations that go far beyond what currently possible. Achieving this project will provide unprecedented tools for the preparation and the use of borylated materials in synthesis and catalysis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences inorganic chemistry metalloids
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
52062 Aachen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.