Natural Products Research at Latvian Institute of Organic Synthesis as a driver for Excellence in Innovation

Información del proyecto

Natalion

Identificador del acuerdo de subvención: 101087181

DOI

10.3030/101087181

Fecha de la firma de la CE 11 Octubre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2027

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 2 499 950,00

Aportación de la UE

€ 2 499 950,00

Coordinado por

LATVIJAS ORGANISKAS SINTEZES INSTITUTS
Latvia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (1)

Natalion Data Management plan

Websites, patent fillings, videos etc. (2)

Report (1) on PEDR update and progress

Report on PEDR update and progress

Report (2) on PEDR update and progress

Report on PEDR update and progress

Documents, reports (2)

Operational report (1) of LIOS Innovation hub (incl. report on service package, training and interrelation build up)

Operational report of LIOS Innovation hub (incl. report on service package, training and interrelation build up)

Report on establishment and launching of LIOS Innovation hub

Publicaciones

Peer reviewed articles (12)

Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide

Autores: Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Publicado en: ACS Chemical Biology, Edición 20, 2025, ISSN 1554-8929
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSCHEMBIO.4C00693

The Advancement of Peptides Derived from Kitasatospora

Autores: Jabal Rahmat Haedar, Abujunaid Habib Khan, Anitra Zīle, Chin-Soon Phan
Publicado en: Chemistry & Biodiversity, 2024, ISSN 1612-1872
Editor: Wiley
DOI: 10.1002/cbdv.202402999

Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity

Autores: Chin-Soon Phan, Brandon I. Morinaka
Publicado en: RSC Chemical Biology, Edición 5, 2024, ISSN 2633-0679
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4cb00227j

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Autores: Zdouc, M. M. et. al.
Publicado en: Nucleic Acids Research, 2024, ISSN 1362-4962
Editor: Oxford Academic
DOI: 10.1093/NAR/GKAE1115

Cyanobacterial Cyclic Peptides Containing <i>cis</i> ‐Pro Conformation

Autores: Jabal Rahmat Haedar, Abujunaid Habib Khan, Christopher R. Coxon, Chin‐Soon Phan
Publicado en: Chemistry – A European Journal, 2026, ISSN 0947-6539
Editor: Wiley
DOI: 10.1002/CHEM.202502932

P450 cyptide synthase MpoB catalyzes the cross-linking of the YPW motif on the precursor peptide

Autores: Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Publicado en: RSC Chemical Biology, 2025, ISSN 2633-0679
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5CB00153F

Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024

Autores: Abujunaid Habib Khan, Chin-Soon Phan
Publicado en: Frontiers in Natural Products, Edición 4, 2025, ISSN 2813-2602
Editor: Frontiers Media SA
DOI: 10.3389/FNTPR.2025.1616031

P450 Cyptide Synthase AscB Catalyzes Fused Cyclophane at the YxWxH Motif on the Precursor Peptides

Autores: Jabal Rahmat Haedar, Abujunaid Habib Khan, Jemma Gullick, Mathias H. Hansen, Laura J. Coe, James J. De Voss, Viktors Romanuks, Gints Smits, Stefano Donadio, Max J. Cryle, Chin-Soon Phan
Publicado en: Organic Letters, Edición 28, 2026, ISSN 1523-7060
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.6C01044

Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs

Autores: Abujunaid Habib Khan, Jabal Rahmat Haedar, Anitra Zīle, Chin-Soon Phan
Publicado en: Tetrahedron Chem, Edición 14, 2025, ISSN 2666-951X
Editor: Elsevier BV
DOI: 10.1016/J.TCHEM.2025.100128

S9 protease WprP2 catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis

Autores: Jabal Rahmat Haedar, Abujunaid Habib Khan, Suze Ma, Stefano Donadio, Chin-Soon Phan
Publicado en: Communications Chemistry, 2026, ISSN 2399-3669
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S42004-026-01915-W

P450 Cyptide Synthase KwwB Catalyzes Trp-C5–Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides

Autores: Jabal Rahmat Haedar, Gaja Swarna Kumari, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Publicado en: Organic Letters, 2025, ISSN 1523-7060
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C04848

P450 Biarylitide Synthase ShyB Catalyzes the Cross-Link Between His-C2 and Tyr-O4 on the Precursor Peptide

Autores: Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Publicado en: Organic Letters, 2025, ISSN 1523-7060
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C01487

Book chapters (1)

Marine Natural Products from Malaysia

Autores: Abujunaid Habib Khan, Chin-Soon Phan
Publicado en: Marine Natural Products Research in South-East Asia, 2025
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-032-01098-8_3